The long non-coding RNA MALAT1 interacted with miR-218 modulates choriocarcinoma growth by targeting Fbxw8

Shi, Dazun; Zhang, Yu; Lü, Rong; Zhang, Yi

doi:10.1016/j.biopha.2017.10.083

Cited by 40 publications

(33 citation statements)

References 42 publications

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“…Current researches concentrated on lncRNAs almost cover all physiological and pathological processes, incorporating the occurrence and development of cancers [26,27]. Emerging evidence uncovered that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) could accelerate choriocarcinoma JEG-3 and JAR cell proliferation and trigger cell cycle arrest [28]. As a neoteric lncRNA, CHRF has been testified to participate in aggrandizing colorectal cancer cell metastasis through regulating Twist and epithelial-mesenchymal transition (EMT) pathways [29].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF

Wang

Wang²,

Liu³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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The comprehensive pathological peculiarities of Neferine (NEF) have been testified in disparate diseases. But, the functions of NEF in choriocarcinoma progression remain unexplored. The research endeavoured to uncover the anti-tumour action of NEF in choriocarcinoma cells. NEF at diverse doses was employed to dispose JEG-3 and HTR-8 cells, and cell viability assessment adopted CCK-8 assay. After 60 lg/mL NEF management, BrdU-positive cells, apoptosis, migration, invasion and correlative factors were assessed. CHRF expression in choriocarcinoma tumour and choriocarcinoma cell lines was estimated via RT-qPCR. Then, the functions of overexpressed CHRF in NEF-disposed cells were determined. At last, impacts of NEF on PI3K/AKT/mTOR and ERK1/2 pathways were evaluated. Results showed that NEF restrained cell proliferation, triggered apoptosis and repressed migration and invasion in JEG-3 and HTR-8 cells. CHRF was ascended in choriocarcinoma tissues and NEF repressed CHRF expression in choriocarcinoma cell lines. Additionally, overexpressed CHRF abolished the above functions of NEF in choriocarcinoma cells proliferation, apoptosis, migration and invasion. Further, NEF impeded PI3K/AKT/mTOR and ERK1/2 pathways via repressing CHRF. The explorations testified that NEF exhibited the anti-tumour action in JEG-3 and HTR-8 cells via hindering PI3K/AKT/mTOR and ERK1/ 2 pathways by mediating CHRF.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF

Wang

Wang²,

Liu³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…MALAT1 knockdown and proliferation of human choriocarcinoma cells in vitro were markedly hindered, and the tumor size in vivo was reduced. The study indicated that MALAT1 may be an oncogenic lncRNA promoting proliferation of choriocarcinoma and it may be a therapeutic target in human choriocarcinoma (29).…”

Section: Discussionmentioning

confidence: 97%

MALAT1 promotes angiogenesis of breast cancer

Huang

Xia

et al. 2018

Oncol Rep

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Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA (lncRNA) that has an oncogenic role in some types of cancers, uncluding breast cancer (BC). To investigate the role of MALAT1 in human BC progression, we detected MALAT1 expression levels based on tissue samples from 20 BC cases and 20 healthy controls and found MALAT1 expression levels to be significantly high (P<0.05). Then, we knocked down endogenous MALAT1 in MCF‑7 cells using MALAT1 short hairpin RNA (shRNA). The results revealed that MALAT1 knockdown could significantly inhibit proliferation, migration, and tube formation in vitro. In addition, miR‑145 expression inversely changed in BC tissue cases. Furthermore, knockdown of endogenous MALAT1 significantly increased miR‑145 levels in MCF‑7 cells. This finding indicated an interaction between MALAT1 and miR‑145. In addition, knockdown of MALAT1 significantly reduced the expression of vascular endothelial growth factor in MCF‑7 cells. This outcome revealed that MALAT1 promoted angiogenesis in BC, which may be related to the expression of miR‑145.

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“…MicroRNAs (miRNA/miRs) are small, non-coding RNAs that regulate the expression of multiple genes at the post-transcriptional level by inducing degradation of target mRNAs or by inhibiting translation (5,6). Increasing evidence indicates that miRNAs regulate a variety of tumor cell processes, including proliferation, invasion, apoptosis and chemoresistance (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218

et al. 2019

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Accumulating evidence has revealed that survivin expression is associated with a malignant phenotype and poor prognosis in glioma. Survivin is also a potential target of microRNA (miRNA/miR)-218. The aim of the present study was to investigate the expression and function of survivin in glioblastoma, and to examine the association between survivin and miR-218. For that purpose, survivin mRNA levels were analyzed in 144 frozen samples of glioblastoma using whole-genome RNA sequencing. In vitro cell proliferation, migration, invasion and apoptosis assays were performed, and survivin expression was detected by western blotting. The results revealed that the mRNA expression levels of survivin were negatively and significantly associated with overall survival in glioblastoma. Further in vitro analyses suggested that miR-218 may inhibit the expression of survivin. Expression of miR-218 in the LN229 cell line was significantly lower than that in the immortalized human gliocyte HEB cell line. miR-218 markedly inhibited tumor cell proliferation, migration and invasion capacities, and decreased apoptosis. miR-218 also inhibited the expression of survivin. These results indicated that survivin may be a target of miR-218 and could serve as a predictive biomarker.

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The long non-coding RNA MALAT1 interacted with miR-218 modulates choriocarcinoma growth by targeting Fbxw8

Cited by 40 publications

References 42 publications

RETRACTED ARTICLE: Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF

RETRACTED ARTICLE: Neferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF

MALAT1 promotes angiogenesis of breast cancer

Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA‑218

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