The long non‐coding RNA SNHG1 promotes bladder cancer progression by interacting with miR‐143‐3p and EZH2

Abstract

Bladder cancer (BC), one of the most lethal neoplasms of the genitourinary system worldwide, has shown a trend towards increasing incidence and mortality rates in recent years. 1 Despite substantial progress in understanding the pathophysiology of BC, the exact mechanisms underlying bladder carcinogenesis remain unclear. Therefore, identifying novel molecular targets and more effective therapeutic approaches is of crucial importance to improve the treatment and prognosis of BC. Currently, emerging evidence has indicated that non-coding RNAs (ncRNAs) are involved in the pathogenesis of human carcinomas, providing novel insights into mechanistic research on the occurrence and development of malignant neoplasms. 2 miRNAs are a group of small ncRNAs with an average length of 20-24 nucleotides that mediate the translational suppression or degradation of mRNAs by binding to their 3′-untranslated regions (3′-UTRs). 3 Additionally, lncRNAs are a subgroup of ncRNAs that have lengths greater than 200 bp. It has been generally recognized

LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA

“…An increasing number of studies have demonstrated the essential role of lncRNAs in bladder cancer development, such as lncRNA SNHG1, lncRNA DLX6-AS1, and lncRNA SNHG3. All these lncRNAs facilitate bladder cancer progression by enhancing cell growth and reducing cell apoptosis [ 47 – 49 ]. Furthermore, several studies have revealed that LINC00958 acts as an oncogenic driver in bladder cancer [ 14 , 42 , 50 ].…”

Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis

“…Some studies have reported that noncoding RNAs (ncRNAs) play important roles in multiple diseases ( Kurt et al., 2020 ; Mi et al., 2020 ; Xiang et al., 2020 ). Among these ncRNAs, long noncoding RNAs (lncRNAs) are more than 200 nucleotides in length and have limited or no protein-coding capacity ( Liu et al., 2020 ).…”

Clinicopathological and prognostic value of long noncoding RNA SNHG7 in cancers: a meta-analysis and bioinformatics

“…For example, Liu et al proved that lncRNA GASL1 inhibited cell proliferation and metastasis by sponging microRNA-106a in gastric carcinoma [ 39 ]. Xiang et al confirmed that SNHG7, as an endogenous ceRNA, could regulate HK2 expression via sponging miR-143-3p to promote the proliferation of bladder cancer [ 40 ]. Besides, in hepatocellular carcinoma, lncRNA NKILA has been reported for suppressing NF-κB/Slug pathway mediated with epithelial-mesenchymal transition to inhibit tumor metastasis [ 41 ].…”