The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells

Xu, Ran; Mao, Yuqiang; Chen, Kuanbing; He, Wei; Shi, Wenjing; Ye, Han

doi:10.18632/oncotarget.16640

Cited by 46 publications

(46 citation statements)

References 26 publications

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“…LncRNA ANRIL is overexpressed in LUAD tissues and in A549/PTX cells. ANRIL can inhibit apoptosis and induce taxanes resistance via Bcl-2 upregulation and cleaved PARP downregulation (Xu et al, 2017). LncRNA CCAT1 serves as the molecular sponge of let-7c and further upregulates Bcl-xL, which enhances proliferation, attenuates apoptosis, and promotes chemical resistance in LUAD cells (Chen et al, 2016a).…”

Section: Lncrnas and Nsclc Taxanes Resistancementioning

confidence: 99%

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

et al. 2019

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Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistance affected the prognosis of patients severely. Accumulating evidence reveals that long non-coding RNAs (lncRNAs), as "dark matters" of the human genome, is of great significance to drug resistance in NSCLC. Herein, we review the role of lncRNAs in drug resistance in NSCLC.

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Section: Lncrnas and Nsclc Taxanes Resistancementioning

confidence: 99%

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

et al. 2019

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“…Long noncoding RNAs (lncRNAs) are novel members of noncoding RNAs with no or limited protein-coding capacity (9,19,22). Increasing studies have shown that several dysregulated lncRNAs act vital roles in cancer genesis through modulating posttranscriptional regulation or gene transcription (18,32,33,35,41). LncRNAs were proven to involve a large range of cellular processes including cell cycle, development, differentiation, growth, apoptosis, and migration (6,8,12,36).…”

Section: Introductionmentioning

confidence: 99%

The long noncoding RNA SNHG1 promotes nucleus pulposus cell proliferation through regulating miR-326 and CCND1

Zhao

Song

et al. 2018

American Journal of Physiology-Cell Physiology

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Aberrant nucleus pulposus cell proliferation is implicated in the development of intervertebral disk degeneration (IDD). Recent studies have suggested that long noncoding RNAs (lncRNAs) can modulate cell proliferation in several pathological conditions. Here, we indicate that expression of SNHG1 was upregulated in IDD tissues compared with control tissues and that higher SNHG1 expression was associated with disk degeneration grade. In addition, we show that ectopic expression of SNHG1 promoted nucleus pulposus (NP) cell proliferation and increased the PCNA and cyclin D1 expression in NP cells. Ectopic expression of SNHG1 inhibited miR-326 expression in nucleus pulposus cells and promoted CCND1 expression, which is a direct target gene of SNHG1. Moreover, we demonstrate that expression of miR-326 was downregulated in IDD tissues compared with control tissues and that lower SNHG1 expression was associated with disk degeneration grade. Expression of miR-326 was negatively associated with SNHG1 expression in disk degeneration tissues. Overexpression of miR-326 inhibited NP cell growth and inhibited PCNA and cyclin D1 expression in NP cells. Furthermore, we show that overexpression of SNHG1 promoted nucleus pulposus cell proliferation through inhibiting miR-326 expression. These data shed novel light on the role of SNHG1 in the pathogenesis of IDD.

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“…In ovarian 43 and bladder 44 In HCC, sponging of liver enriched miR-122-5p by ANRIL induces cell proliferation, metastasis and invasion 47 . Interestingly, ANRIL was reported to contribute to paclitaxel resistance in lung cancer, partly through poly(ADP-ribose) polymerase (PARP) and BCL2 modulating mitochondrial pathway 48 .…”

mentioning

confidence: 99%

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Angenard

Merdrignac

Louis

et al. 2019

Digestive and Liver Disease

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Background: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide associated with an increased incidence, limited therapeutic options and absence of reliable prognostic biomarkers. Long non-coding RNAs (lncRNA) emerge as relevant biomarkers in cancer being associated with tumor progression. However, lncRNA have been poorly investigated in iCCA. Aim: To identify lncRNA significantly associated with the survival of patients with iCCA after tumor resection for curative intent. Methods: Gene expression profiling and Q-RT-PCR were performed from a cohort of 39 clinically well-annotated iCCA. Univariate Cox proportional hazards model with Wald Statistic was used to identify lncRNA significantly associated with overall (OS) and/or disease-free (DFS) survival. Results: A signature made of 9 lncRNA was identified to be significantly (P<0.05) associated with OS and DFS, including 4 lncRNA (lnc-CDK9-1, XLOC_l2_009441, CDKN2B-AS1, HOXC13-AS) highly expressed in poor prognosis iCCA and 5 lncRNA (lnc-CCHCR1-1, lnc-AF131215.3.1, lnc-CBLB-5, COL18A1-AS2, lnc-RELL2-1) highly expressed in better prognosis iCCA. We further validated CDKN2B-AS1 (ANRIL) as a poor prognosis biomarker, not only in iCCA, but also in hepatocellular carcinoma, kidney renal clear cell carcinoma and uterine corpus endometrial carcinoma. Conclusions: We report a prognosis lncRNA signature in iCCA and the clinical relevance of CDKN2B-AS1 (ANRIL) overexpression in several cancers.

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The long noncoding RNA ANRIL acts as an oncogene and contributes to paclitaxel resistance of lung adenocarcinoma A549 cells

Cited by 46 publications

References 26 publications

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review

The long noncoding RNA SNHG1 promotes nucleus pulposus cell proliferation through regulating miR-326 and CCND1

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

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