The long noncoding RNA FTH1P3 promotes the proliferation and metastasis of cervical cancer through microRNA‑145

Lv, Rui; Zhang, Qian Wen

doi:10.3892/or.2019.7413

Cited by 9 publications

(7 citation statements)

References 37 publications

(36 reference statements)

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“…The high levels of lncRNA Ferritin Heavy Chain 1 Pseudogene 3 (FTH1P3) in UM correlate with proliferation, cell cycle, and migration. It is dysregulated in other cancers such as lung, cervical, glioma, esophageal carcinoma, and breast cancer [106][107][108][109][110]. It is suggested that lncRNA FTH1P3 decreases miR-224-5p expression and enhances Fizzled 5 and Ras-related C3 botulinum toxin substrate 1 (Rac1) expression, promoting cell cycle progression and migration [70].…”

Section: Oncogenic Lncrnas In Uveal Melanomamentioning

confidence: 99%

The Role of LncRNAs in Uveal Melanoma

Milán-Rois

Quan

Slack

et al. 2021

Cancers

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Uveal melanoma (UM) is an intraocular cancer tumor with high metastatic risk. It is considered a rare disease, but 90% of affected patients die within 15 years. Non-coding elements (ncRNAs) such as long non-coding RNAs (lncRNAs) have a crucial role in cellular homeostasis maintenance, taking part in many critical cellular pathways. Their deregulation, therefore, contributes to the induction of cancer and neurodegenerative and metabolic diseases. In cancer, lncRNAs are implicated in apoptosis evasion, proliferation, invasion, drug resistance, and other roles because they affect tumor suppressor genes and oncogenes. For these reasons, lncRNAs are promising targets in personalized medicine and can be used as biomarkers for diseases including UM.

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Section: Oncogenic Lncrnas In Uveal Melanomamentioning

confidence: 99%

The Role of LncRNAs in Uveal Melanoma

Milán-Rois

Quan

Slack

et al. 2021

Cancers

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“…FTH1P3 is a newly identified lncRNA in cancer cells, and its overexpression in cancer cell lines and tissues has been demonstrated by several studies. FTH1P3 can promote cell proliferation, migration, invasion, and tumor progression in uveal melanoma [ 194 ], oral squamous cell carcinoma [ 193 ], laryngeal squamous cell carcinoma [ 195 ], cervical cancer [ 196 ], and NSCLC. Zheng et al reported that the expression level of FTH1P3 was upregulated in uveal melanoma cell lines (C918, MUM-2B, OCM-1A, and MUM-2C) compared to that melanocyte cell line (D78).…”

Section: Introductionmentioning

confidence: 99%

RHO GTPase-Related Long Noncoding RNAs in Human Cancers

Saliani

Mirzaiebadizi

Mosaddeghzadeh

et al. 2021

Cancers

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RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis.

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“…For instance, lncRNA PTCSC3 was reported as a biomarker for the treatment and prognosis of gastric cancer (Zhang et al., 2020 ). LncRNA FTH1P3 was highly expressed in cervical cancer cells and it could facilitate cell proliferation via interacting with miR‑145 (Lv & Zhang, 2020 ). LncRNA MATN1‐AS1 was downregulated in GBM cells and could repress cell proliferation and invasion through regulating RELA (Han et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA DLGAP1‐AS1 accelerates glioblastoma cell proliferation through targeting miR‐515‐5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway

Wang

Han

et al. 2021

Brain and Behavior

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Introduction: Glioblastoma (GBM), the primary malignant tumor in the central nervous system, features high aggressiveness and mortality. Long noncoding RNAs (lncRNAs) can exert the crucial function in regulating various human diseases, including GBM.However, the function and mechanism of lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) in GBM remain still unknown. Methods: DLGAP1-AS1 expression in GBM cells was detected by RT-qPCR. Functional assays were conducted to determine GBM cell proliferation and apoptosis. RIP, RNA pull down, and luciferase reporter assay were applied for measuring the interplay of DLGAP1-AS1 with other RNAs. Results: DLGAP1-AS1 was distinctly upregulated in GBM cells. DLGAP1-AS1 depletion inhibited cell proliferation, but induced apoptosis. MiR-515-5p could be sponged by DLGAP1-AS1 in GBM cells and to repress cell proliferation in GBM. Further, Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and Nuclear factor erythroid-2 like 1 (NFE2L1) were confirmed as the target gene of miR-515-5p. Wnt signaling pathway could be activated by DLGAP1-AS1 via regulating ROCK1 and NFE2L1 expression. Rescue assays proved that overexpression of both ROCK1 and NFE2L1 could totally reverse the inhibitory effect of silencing DLGAP1-AS1 on GBM cell proliferation. Conclusion: LncRNA DLGAP1-AS1 accelerated cell proliferation in GBM via targeting miR-515-5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway.

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The long noncoding RNA FTH1P3 promotes the proliferation and metastasis of cervical cancer through microRNA‑145

Cited by 9 publications

References 37 publications

The Role of LncRNAs in Uveal Melanoma

The Role of LncRNAs in Uveal Melanoma

RHO GTPase-Related Long Noncoding RNAs in Human Cancers

LncRNA DLGAP1‐AS1 accelerates glioblastoma cell proliferation through targeting miR‐515‐5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway

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