The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1

Zhang, Peng; Wang, Jun; Shan, Bin; Li, Bin; Peng, Wei; Dong, Yeping; Shi, Weisong; Zhao, Wenyuan; He, Dan; Duan, Minghao; Cheng, Yuanda; Zhang, Chunfang; Duan, Chaojun

doi:10.1186/s12943-018-0920-z

Cited by 102 publications

(85 citation statements)

References 10 publications

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“…In lung adenocarcinoma, LINC00312 was found to regulate migration, invasion, and VM processes of lung cancer cells. LINC00312 directly binds to the transcription factor Y-box binding protein 1 (YBX1) to regulate VM formation [26]. In ovarian cancer, miR-200a and miR-27b have been reported to be significantly downregulated, and their expression levels were inversely correlated with VM formation.…”

Section: Non-coding Rnas As Emerging Regulators In Tumor Vm Formationmentioning

confidence: 99%

“…There are several potential mechanisms of VM formation, such as epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) [22,23], and various signaling pathways that promote VM formation, including vascular endothelial (VE)-cadherin, erythropoietin-producing hepatocellular receptor A2 (EphA2), phosphatidyl inositol 3-kinase (PI3K), matrix metalloproteinases (MMPs), vascular endothelial growth factor receptor (VEGFR1), cyclic adenosine monophosphate (cAMP), focal adhesion kinase (FAK), and hypoxia inducible factor (HIF)-1a [24,25]. Moreover, noncoding RNAs such as lncRNAs and miRNAs play critical roles in VM formation in malignant tumors [16,[26][27][28]. In this review, we provide new insights into the complexity of vasculogenic mimicry and summarize the latest findings of VM formation in malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

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Vasculogenic mimicry in carcinogenesis and clinical applications

et al. 2020

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Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood supply for tumor cells independent of endothelial cells. VM has two distinct types, namely tubular type and patterned matrix type. VM is associated with high tumor grade, tumor progression, invasion, metastasis, and poor prognosis in patients with malignant tumors. Herein, we discuss the recent studies on the role of VM in tumor progression and the diverse mechanisms and signaling pathways that regulate VM in tumors. Furthermore, we also summarize the latest findings of non-coding RNAs, such as lncRNAs and miRNAs in VM formation. In addition, we review application of molecular imaging technologies in detection of VM in malignant tumors. Increasing evidence suggests that VM is significantly associated with poor overall survival in patients with malignant tumors and could be a potential therapeutic target.

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Section: Non-coding Rnas As Emerging Regulators In Tumor Vm Formationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vasculogenic mimicry in carcinogenesis and clinical applications

et al. 2020

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“…Accumulating data show that down-regulation of lncRNA NKILA or up-regulation of XLOC_008466 and FAL1 is linked to lymph node metastasis and TNM stage, 12,13,15 and lncRNA AFAP1-AS1, linc00673 and PVT1 predict a poor prognosis in NSCLC. 10,16,17 lncRNA DLEU2 is identified to have a differential expression in LAC, 20 acute myeloid leukaemia 21 and laryngeal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…oncogenes 11,12 or anti-oncogenes in NSCLC. 6,13 LncRNA AFAP1-AS1, linc00460 and LINC00312 facilitate the proliferation, invasion and epithelial-mesenchymal transition, 5,11,12 while EPB41L4A-AS2 6 and NKILA 13 have the opposite effects in NSCLC cells.…”

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confidence: 99%

LncRNA DLEU2 accelerates the tumorigenesis and invasion of non–small cell lung cancer by sponging miR‐30a‐5p

Zhao

Gao

et al. 2019

J Cellular Molecular Medi

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Long non‐coding RNAs (lncRNAs) have been reported to participate in the pathogenesis of non–small cell lung cancer (NSCLC). However, how lncRNA deleted in lymphocytic leukaemia 2 (DLEU2) contributes to NSCLC remains undocumented. The clinical significance of lncRNA DLEU2 and miR‐30a‐5p expression in NSCLC was analysed by using fluorescence in situ hybridization and TCGA cohorts. Gain‐ and loss‐of‐function experiments as well as a NSCLC tumour model were executed to determine the role of lncRNA DLEU2 in NSCLC. DLEU2‐sponged miR‐30a‐5p was verified by luciferase reporter, and RIP assays. Herein, the expression of lncRNA DLEU2 was elevated in NSCLC tissues, and its high expression or low expression of miR‐30a‐5p acted as an independent prognostic factor of poor survival and tumour recurrence in NSCLC. Silencing of lncRNA DLEU2 repressed the tumorigenesis and invasive potential of NSCLC, whereas re‐expression of lncRNA DLEU2 showed the opposite effects. Furthermore, lncRNA DLEU2 harboured a negative correlation with miR‐30a‐5p expression in NSCLC tissues and acted as a sponge of miR‐30a‐5p, which reversed the tumour‐promoting effects of lncRNA DLEU2 by targeting putative homeodomain transcription factor 2 in NSCLC. Altogether, lncRNA DLEU2 promoted the tumorigenesis and invasion of NSCLC by sponging miR‐30a‐5p.

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“…LncRNA HOXA-AS2 IGF2 57 LncRNA Myocardial infarction-associated transcript (MIAT) TDP43 58 LncRNA PXN-AS1-L PXN 59 LncRNA LINC00312 Y-Box Binding Protein 1 (YBX1) 60 LncRNA LINC00707 CDC42 61 LncRNA MALAT1 TDP43 62 PTEN/AKT and Akt/mTOR. Recent studies confirmed that many LncRNAs could exert their regulating NSCLC metastasis function by influencing the transduction of different signal pathways.…”

Section: Oncogenic Lncrnas Target Proteins Referencementioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

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Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

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The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1

Cited by 102 publications

References 10 publications

Vasculogenic mimicry in carcinogenesis and clinical applications

Vasculogenic mimicry in carcinogenesis and clinical applications

LncRNA DLEU2 accelerates the tumorigenesis and invasion of non–small cell lung cancer by sponging miR‐30a‐5p

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

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