The long noncoding RNA urothelial carcinoma-associated 1 overexpression as a poor prognostic biomarker in clear cell renal cell carcinoma

Yang, Wang; Gao, Wen; Xu, Jiali; Zhu, Yinsu; Liu, Lingxiang

doi:10.1177/1010428317698377

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…As an example, in metastatic ccRCC tissues, lncRNA termed metastatic renal cell carcinoma-associated transcript 1 (MRCCAT1) is ectopic upregulated, which might cause the metastatic capacity of ccRCC via mediating associated signalling transduction systems [18]. Besides, lncRNA UCA1 is overexpressed in ccRCC and the overexpression of UCA1 has been regarded as a poor prognostic biomarker in ccRCC diagnosis [19]. In our present study, we found LINC01939 was obviously downregulated in RCC tissues.…”

Section: Discussionmentioning

confidence: 49%

Long intergenic non-coding RNA 1939 eliminates proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154

Zhang

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Renal carcinoma (RCC) is widely accepted as a malignant tumour of urinary system. Long intergenic non-coding RNA 1939 (LINC01939) is a novel lncRNA which was found to be down-regulated in RCC. Thus, we set out to explore the effect and regulation mechanism of LINC01939 in RCC. LINC01939 and miR-154 in RCC tissues and cell lines were detected using qRT-PCR assay. To examine cellular viability of ACHN and CAKI-1 cells, cell counting kit-8 (CCK-8) assay was exploited here. Flow cytometric analysis was conducted to examine apoptosis. Cell mobility was valued through wound healing assays. Western blotting was applied for examination of proteins related to proliferation, apoptosis, migration and Wnt/ b-catenin/Notch. LINC01939 was down-regulated in RCC tissues. LINC01939 overexpression impeded proliferation and migration, and induced apoptosis. Further study found that the overexpression of LINC01939 strongly suppressed miR-154 expression. Then, the inhibiting effect of overexpressed LINC01939 on proliferation and mobility and the promoting role of LINC01939 in apoptosis were abolished by the combination of miR-154 mimic. Finally, we found that overexpressed LINC01939 inactivated Wnt/b-catenin and Notch through suppressing miR-154. Up-regulation of LINC01939 inhibited proliferation and migration of RCC cells by down-regulating miR-154.

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Section: Discussionmentioning

confidence: 49%

Long intergenic non-coding RNA 1939 eliminates proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154

Zhang

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…RCC is one of the most common malignancies, and ccRCC represents the majority of RCC. ccRCC patients can show different clinical manifestation and treatment response because of the tumor heterogeneity in histology, oncogenicity and molecular alterations in tumor suppressor genes [ 24 ]. Furthermore, previous reports have shown that the mutations on Von Hippel-Lindau ( VHL ), Polybromo-1 ( PBRM1 ) and BRCA1 associated protein-1 ( BAP1 ) are the most common somatic mutations in ccRCC which induces the occurrence and development of ccRCC [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA LOC653786 promotes growth of RCC cells via upregulating FOXM1

Yang

Zhang

et al. 2018

Oncotarget

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Renal cell carcinoma (RCC) is the most common kidney malignancy with poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been demonstrated as important regulators in multiple cancers including RCC. LOC653786 is a lncRNA, but its role in cancer remains unclear. In this study, we for the first time found that LOC653786 was upregulated in RCC tissues and cell lines, and this lncRNA promoted growth and cell cycle progression of RCC cells. Moreover, we showed that LOC653786 elevated the expression of forkhead box M1 (FOXM1) and its downstream target genes cyclin D1 and cyclin B1 in RCC cells. Reporter assay revealed that LOC653786 enhanced the transcriptional activity of FOXM1 gene promoter. Additionally, knockdown of FOXM1 attenuated the LOC653786-enhanced growth and cell cycle progression of RCC cells. Meanwhile, silencing of LOC653786 suppressed RCC cell growth and cell cycle progression, which was alleviated by overexpression of FOXM1. The in vivo experiments in nude mice showed knockdown of LOC653786 repressed xenograft tumor growth and FOXM1 expression. In conclusion, our results demonstrate that LOC653786 accelerates growth and cell cycle progression of RCC cells via upregulating FOXM1, suggesting that the ‘LOC653786/FOXM1’ pathway may serve as a novel target for RCC treatment.

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“…With the development of lncRNA biology, a growing number of functional lncRNAs in RCC progression have been identified. In patients with RCC, the dysregulation of lncRNAs can promote the progression of RCC, resulting in poor prognosis (31)(32)(33). RCC tumorigenesis is a complex biological process that involves not only mutations in genetic networks but also epigenomic alterations that can trigger imbalances in cellular homeostasis and ultimately lead to abnormal cell growth.…”

Section: Introductionmentioning

confidence: 99%

The roles of long non‑coding RNAs in renal cell carcinoma (Review)

Zhao

et al. 2022

Mol Clin Oncol

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Long non-coding RNAs (lncRNAs) are involved in the gene expression regulation and usually play important roles in various human cancers, including the renal cell carcinoma (RCC). Dysregulation of certain lncRNAs are associated with the prognosis of patients with RCC. In the present review, several recently studied lncRNAs were discussed and their critical roles in proliferation, migration, invasion, apoptosis and drug resistance of renal cancer cells were revealed. The research on lncRNAs further increases our understanding on the development and progression of RCC. It is suggested that lncRNAs can be used as biomarkers or therapeutic targets for diagnosis or treatment of renal cancer. Contents1. Introduction 2. Features and functions of lncRNAs in carcinogenesis 3. lncRNAs and RCC 4. Conclusions

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The long noncoding RNA urothelial carcinoma-associated 1 overexpression as a poor prognostic biomarker in clear cell renal cell carcinoma

Cited by 5 publications

References 54 publications

Long intergenic non-coding RNA 1939 eliminates proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154

Long intergenic non-coding RNA 1939 eliminates proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154

LncRNA LOC653786 promotes growth of RCC cells via upregulating FOXM1

The roles of long non‑coding RNAs in renal cell carcinoma (Review)

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