The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction

Lee, G.-K.; Lee, L.-C.; Chong, Eric; Lee, C.-H.; Teo, Swee‐Guan; Chia, B.L.; Poh, Kian Keong

doi:10.1093/qjmed/hcs123

Cited by 55 publications

(51 citation statements)

References 47 publications

(54 reference statements)

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“…Regarding this last aspect, the literature data seem to be contrasting; in fact, while some authors found a difference in NLR in relation to the diabetic disease [5,29,35], others did not point out this trend [13,22,24,27,43]. In our small survey this ratio differentiates smokers and non smokers and this datum seems to agree with the findings of several authors [5,13,22,35], but it is different from which observed by others [24,27,43].…”

Section: Conclusive Considerationscontrasting

confidence: 82%

“…The average NLR results the best predictor of short-and long-term survival compared to other leukocyte parameters, such as neutrophil or lymphocyte count [5], probably because this ratio is less altered by other conditions, such as dehydration or over-hydration [4]. Lee et al have demonstrated that the NLR value at the admission is an independent predictor of 1-year reinfarction and mortality in diabetic subjects with AMI [29].…”

Section: Introductionmentioning

confidence: 99%

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Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Caimi

Presti

Canino

et al. 2016

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Abstract. In the last years the neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and in particular in coronary artery disease and acute myocardial infarction (AMI). Now we examined this parameter in subjects with juvenile myocardial infarction at the initial stage and after 3 and 12 months. We enrolled 123 young subjects (112 men and 11 women, mean age 39.4 ± 5.8 yrs) with AMI. The time interval between the AMI onset and the investigation was 13 ± 7 days. The mean value of NLR observed in young AMI subjects was significantly increased compared to normal controls (N = 1.817 ± 0.711; young AMI subjects = 2.376 ± 0.873, p < 0.0001). NLR does not discriminate STEMI (2.427 ± 0.878) and non STEMI (2.392 ± 0.868) or diabetics (2.604 ± 1.000) and non diabetics (2.324 ± 0.853), but it differentiates smokers (2.276 ± 0.853) and non smokers (2.837 ± 1.072). NLR at the initial stage is not correlated with the number of cardiovascular risk factors or with the extent of the coronary disease. In this study we found a significant decrease of neutrophil count at 3 and 12 months later AMI without any significant variation of lymphocyte and consequently we observed a decrease in NLR at these two intervals of time in comparison with the initial stage. Despite some limitations present in this study, it is interesting to underline that also in juvenile myocardial infarction this low-cost haematological marker may be considered together with other inflammatory indicators.

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Section: Conclusive Considerationscontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Caimi

Presti

Canino

et al. 2016

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“…3,4,[16][17][18] During systemic inflammation, the release of cytokines, such as IL-1ra, IL-6, IL-7, IL-8, IL-12 and platelet derived growth factor (PDGF), is followed by neutrophil activation and elevation of NLR. NLR is a more stable measure than the individual neutrophil and lymphocyte counts, and is less affected by conditions which change the individual cell counts.…”

Section: Discussionmentioning

confidence: 99%

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Karabay¹,

Çerman²,

Altunay³

2016

Turkiye Klinikleri J Dermatol

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recent studies implicate the role of inflammatory responses in chronic spontaneous urticaria (CSU). The purpose of this study was to analyse the levels of neutrophil-lymphocyte ratio (NLR), serum C-reactive protein (CRP) and uric acid levels in CSU patients, and to investigate the relationship between these inflammatory parameters and disease activity. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 100 people, consisting of 50 chronic urticaria patients and 50 healthy controls, who have no systemic disease, inflammatory, infectious or autoimmune disease, malignancy, were included in the study. R Re es su ul lt ts s: : NLR and serum CRP levels were significantly higher in patients with CSU than in healthy controls (p< 0.001, p< 0.001, respectively). The levels of uric acid did not show a statistically significant difference between CSU patients and controls (p= 0.359). A significant positive correlation was found between NLR and CRP in patients with CSU (p= 0.001, r= 0.442).When CSU patients were evaluated according to disease severity, serum CRP levels were significantly higher in patients with severe CSU than in patients with mild-moderate CSU (p= 0.038). C Co on nc cl lu us si io on n: : Several biomarkers have been studied in systemic diseases to determine the inflammatory process ongoing and the relationship between these markers and disease activity has been investigated. It can be concluded that CRP and NLR can be used to assess the inflammatory status in CSU and may be useful parameters during the follow-up of these patients. It is known that NLR and CRP are diagnostic and prognostic markers of cardiovascular diseases. Elevated values of NLR and CRP may demand caution regarding cardiovascular comorbidities that may accompany chronic urticaria.K Ke ey y W Wo or rd ds s: : C-reactive protein; neutrophils; uric acid; urticaria Ö ÖZ ZE ET T A Am ma aç ç: : Son dönemde yapılan çalışmalarda kronik spontan ürtikerde (KSÜ) inflamatuar yanıtın üzerinde durulmaktadır. Bu çalışmanın amacı KSÜ hastalarında nötrofil-lenfosit oranı (NLO), serum C-reaktif proteini (CRP) ve ürik asid düzeylerini belirlemek ve bu inflamatuar parametreler ile hastalık aktivitesi arasında ilişki olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Herhangi bir sistemik hastalığı, inflamatuar veya infeksiyöz hastalığı, malignitesi, otoimmün hastalığı olmayan 50 kronik ürtiker hastası ve 50 sağlıklı kontrol olmak üzere toplam 100 kişi çalışmaya dahil edildi. B Bu ul lg gu ul la ar r: : NLO ve CRP düzeyleri KSÜ hastalarında sağlıklı kontrollere göre anlamlı olarak daha yüksekti (p<0,001, p<0,001, sırasıyla). Ürik asid düzeyleri açısından KSÜ hastaları ve sağlıklı kontroller arasında anlamlı bir fark izlenmedi (p=0,359). KSÜ hastalarında NLO ve CRP arasında anlamlı pozitif korelasyon mevcuttu (p=0,001, r=0,442). KSÜ hastaları hastalık şiddetine göre incelendiğinde serum CRP düzeyleri şiddetli KSÜ hastalarında hafif-orta şiddetli KSÜ h...

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“…One major difficulty in using NLR value as a prognosticator in disease processes is determining an appropriate cut-off value around which disease outcomes differ. The appropriate NLR cut-off value is likely to change with the stage of illness, laboratory techniques employed, concomitant infection and patient demographic characteristics (26). In our study, a statistically significant difference in all-cause mortality was found between patients using the cutoff value of 3.…”

Section: Discussionmentioning

confidence: 63%

Value of neutrophil to lymphocyte ratio as a predictor of mortality in patients undergoing aortic valve replacement

Habib

Thawabi²,

Hawatmeh³

et al. 2018

Cardiovasc. Diagn. Ther.

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The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction

Abstract: Increased NLR post-AMI is an independent predictor of major adverse cardiac events in diabetics. Monitoring this easily obtainable new index allows prognostication and risk stratification.

Cited by 55 publications

References 47 publications

Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Behaviour of the neutrophil to lymphocyte ratio in young subjects with acute myocardial infarction

Serum C-Reactive Protein, Neutrophil-Lymphocyte Ratio and Uric Acid Levels in Chronic Spontaneous Urticaria

Value of neutrophil to lymphocyte ratio as a predictor of mortality in patients undergoing aortic valve replacement

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