The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements

Paquette, Jean-Sébastien; Rhéaume, Caroline; Cordeau, Pierre; Moulin, Julie-Alexandra; Audet-Walsh, Etienne; Blanchette, Virginie; Drouin-Chartier, Jean-Philippe; Toi, Alfred-Kodjo; Tremblay, Angelo

doi:10.3390/metabo13111157

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2024

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Cited by 5 publications

References 108 publications

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Maintaining ideal cardiovascular health is associated with higher serum anti-aging protein klotho in the middle-aged and older populations

Kadier,

Liu,

Dilixiati

et al. 2024

The Journal of nutrition, health and aging

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Maintaining ideal cardiovascular health is associated with higher serum anti-aging protein klotho in the middle-aged and older populations

Kadier,

Liu,

Dilixiati

et al. 2024

The Journal of nutrition, health and aging

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The associations between oxidative balance score and serum Klotho level in the U.S. population aged 40–79 years

Wang,

Jiang,

Zhou

et al. 2024

Sci Rep

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The association between serum alpha klotho and circadian syndrome: data from NHANES 2007–2016

Fan,

Huang,

Xiang

et al. 2024

Preprint

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Background Circadian syndrome (CircS) is characterized by disrupted circadian rhythm. α-klotho, an anti-aging protein, has garnered particular attention recently. The study aimed to assess the associations of serum alpha klotho and CircS. Methods Data from National Health and Nutrition Examination Survey (NHANES) 2005-2016 were analyzed. CircS further encompasses sleep disorders and depression, in addition to the components of the metabolic syndrome (MetS). Multivariate logistic regression, subgroup analysis and restricted cubic spline plot were used to analyze the associations. Results We found a negative relationship between circulating α-klotho and the risk of CircS. Using multivariate logistic regression models, we assessed the association between α-klotho and CircS while adjusting for potential confounders. Compared to the first quartile of klotho, the second quartile group showed 16% decrease in CirS risk (OR=0.84, 95%CI = 0.74-0.96, P = 0.012), and the third quartile group exhibited 21% decrease in CirS risk (OR=0.79, 95%CI = 0.69-0.91, p<0.001) after adjusting all demographic and lifestyle variables. Subgroup analyses revealed significant interactions between α-klotho and alcohol consumption (p=0.008). Additionally, we observed inverse association between α-klotho and odds ratio of CirS in a restricted cubic spline plot. Conclusion In this large cross-sectional study, our results suggest that higher serum α-klotho levels are significantly associated with a reduced likelihood of circadian syndrome in U.S. adults. Further studies are needed to confirm these findings and elucidate the underlying mechanisms..

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The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements

Cited by 5 publications

References 108 publications

Maintaining ideal cardiovascular health is associated with higher serum anti-aging protein klotho in the middle-aged and older populations

Maintaining ideal cardiovascular health is associated with higher serum anti-aging protein klotho in the middle-aged and older populations

The associations between oxidative balance score and serum Klotho level in the U.S. population aged 40–79 years

The association between serum alpha klotho and circadian syndrome: data from NHANES 2007–2016

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