The low dose gamma ionising radiation impact upon cooperativity of androgen-specific proteins

Filchenkov, Gennady N.; Popoff, Eugene H.; Наумов, А. Д.

doi:10.1016/j.jenvrad.2013.02.002

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…They further suggested that age might play a major role in the decline of testosterone levels in older men. In a rat study, Filchenkov et al [ 166 ] reported that the exposure to acute external γ irradiation (0.5 Gy from 137Cs source, 10.33 × 10 −4 Gy/s) for 90 days causes fluctuations in testosterone levels. In addition, a sharp upsurge in testosterone level occurred post-exposure to ionizing radiation in venous blood accompanied by decreased testosterone-binding globulin (TeBG), indicating the inhibition of the hormone in the tissues.…”

Section: Environmental Factorsmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

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Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.

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Section: Environmental Factorsmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

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“…В полученных образцах определяли: концентрацию ТБК-активных продуктов, карбонилов белков, конечных продуктов окисления белков, активность глутатион-S-трансферазы [23], супероксиддисмутазы [24], а также концентрацию протеиновых сульфгидрильных (-SH) групп [25]. Концентрация белка в постмитохондриальной фракции ткани печени определялась методом Лоури [26]. Расчёт активности ферментов осуществлялся согласно [27].…”

Section: материал и методыunclassified

The effect of ozonotherapy on the indices of oxidative stress and antioxidant mechanisms in experimental liver cirrhosis

Osipov¹,

Kazlou²

2018

Vestnik VSMU

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Цель-оценить изменения некоторых биохимических показателей окислительного стресса и антиоксидантных механизмов организма при экспериментальном циррозе печени у крыс, а также влияние курса озонотерапии на баланс этих показателей при экспериментальном циррозе печени. Материал и методы. В качестве объекта использовались белые крысы-самцы линии Вистар (n=15). После моделирования цирроза печени (по авторской методике) крысам экспериментальной группы проводился курс озонотерапии. Затем животных выводили из эксперимента и изучали маркеры окислительного стресса и антиоксидантных механизмов в сыворотке крови и ткани печени. Результаты. При экспериментальном циррозе печени у крыс наблюдается статистически значимое повышение показателей маркеров окислительного стресса и снижение активности антиоксидантных ферментов по сравнению с нормальными показателями (p=0,009). Курс озонотерапии при экспериментальном циррозе печени приводит к статистически значимому снижению большинства показателей окислительного стресса (p=0,009) и повышению активности антиоксидантных ферментов и некоторых неферментативных антиоксидантных механизмов (p=0,016 для концентрации протеиновых сульфгидрильных групп в ткани печени и p=0,009 для остальных показателей) по сравнению с животными контрольной группы (с циррозом печени без терапевтических воздействий). Заключение. При экспериментальном циррозе печени наблюдается статистически значимое повышение показателей окислительных процессов и снижение активности антиоксидантных ферментов по сравнению с нормальными показателями. Курс озонотерапии при экспериментальном циррозе печени имеет положительное влияние на дисбаланс окислительных и антиоксидантных процессов, что проявляется статистически значимым снижением уровня большинства исследованных маркеров окислительного стресса и повышением активности антиоксидантных ферментов. Ключевые слова: цирроз печени, озонотерапия, окислительный стресс, антиоксидантные процессы и механизмы, маркеры.

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“…Typically, the cascade releases of gonadotropin‐releasing hormone (GnRH), luteinizing hormone (LH), and follicle‐stimulating hormone (FSH) from hypothalamic arcuate nucleus and adenohypophysis participate in the regulation of the content of testosterone. The previous studies demonstrated HDR‐induced reductions in testosterone contents in rodents or freshwater fish, which were mainly relevant to HDR‐caused the disruption in the hypothalamic–pituitary–testicular axis or/and structural damages of testis tissue (Filchenkov et al, 2014; Lemos et al, 2017). But data from space traveling have shown that LDR exposure induced obvious perturbation in the steroidogenesis of this male steroid hormone without pathological changes in testicular or Leydig's cellular structure, suggesting that the mode of action involved in LDR‐induced changes in testosterone level could be different from that of HDR (Mishra & Luderer, 2019).…”

Section: Introductionmentioning

confidence: 97%

Low‐dose radiation‐induced demethylation of 3β‐HSD participated in the regulation of testosterone content

Huang

Qiu

Yue³

et al. 2021

J of Applied Toxicology

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The effects of low‐dose radiation (LDR, ≤0.1 Gy) on living organisms have been the hot areas of radiation biology but do not reach a definitive conclusion yet. So far, few studies have adequately accounted for the male reproductive system responses to LDR, particularly the regulation of testosterone content. Hence, this study was designed to evaluate the effects of LDR on Leydig cells and testicular tissue, especially the ability to synthesize testosterone. We found that less than 0.2‐Gy 60Co gamma rays did not cause significant changes in the hemogram index and the body weight; also, pathological examination did not find obvious structural alterations in testis, epididymis, and other radiation‐sensitive organs. Consistently, the results from in vitro showed that only more than 0.5‐Gy gamma rays could induce remarkable DNA damage, cycle arrest, and apoptosis. Notably, LDR disturbed the contents of testosterone in mice serums and culture supernatants of TM3 cells and dose dependently increased the expression of 3β‐HSD. After cotreatment with trilostane (Tril), the inhibitor of 3β‐HSD, increased testosterone could be partially reversed. Besides, DNA damage repair‐related enzymes, including DNMT1, DNMT3B, and Sirt1, were increased in irradiated TM3 cells, accompanying by evident demethylation in the gene body of 3β‐HSD. In conclusion, our results strongly suggest that LDR could induce obvious perturbation in the synthesis of testosterone without causing organic damage, during which DNA demethylation modification of 3β‐HSD might play a crucial role and would be a potential target to prevent LDR‐induced male reproductive damage.

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The low dose gamma ionising radiation impact upon cooperativity of androgen-specific proteins

Cited by 6 publications

References 32 publications

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

The effect of ozonotherapy on the indices of oxidative stress and antioxidant mechanisms in experimental liver cirrhosis

Low‐dose radiation‐induced demethylation of 3β‐HSD participated in the regulation of testosterone content

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