The Lund‐Mackay staging system for chronic rhinosinusitis: How is it used and what does it predict?

Hopkins, Claire; Browne, John; Slack, R. W. T.; Lund, Valerie J.; Brown, Peter

doi:10.1016/j.otohns.2007.02.004

Cited by 450 publications

(448 citation statements)

References 26 publications

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“…The classification of disease severity was performed using the SNOT-20 questionnaire (Sino-Nasal Outcome Test), nasal endoscopy and CT scan graded by Lund-Mackay scoring system [18,25]. We also recorded a number of sinus surgeries performed in CRS patients reflecting the recalcitrant sinus disease and intensity of CRS.…”

Section: Methodsmentioning

confidence: 99%

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Chronic rhinosinusitis (CRS) affects 14% of the world population. The high motility group box 1 (HMGB1) protein triggers inflammation, cell proliferation and cell survival through its receptor for advanced glycation end products (RAGE) upon release from stressed or necrotic cells. The aim of the study was to analyze the expression and function of HMGB1 and RAGE in CRS, providing more information about HMGB1 signaling pathway in CRS, to determine its potential clinical significance. Material and methods. Thirty-seven patients with CRS and 26 normal controls (NC) were enrolled in this study. Classification of disease severity using the SNOT-20 questionnaire, nasal endoscopy, CT scan, assessment of allergy status, microbiological and cytological analysis was performed in patients. Fresh sinus mucosa samples were obtained and analyzed by immunohistochemistry for HMGB1 and RAGE expression in epithelial cells. ELISA assay was performed to evaluate the concentration of HMGB1 in the patients' sera. Results. No differences were found in HMGB1 immunoexpression between CRS patients and NC, however there was a highly significant difference in RAGE immunoexpression between both groups. There was a correlation between RAGE expression and number of tissue-infiltrating lymphocytes. Further, RAGE expression positively correlated with disease severity and a positive history for allergies. Conclusions. Interaction of HMGB1 and RAGE might be relevant to CRS pathomechanisms leading to sinus mucosa hyperproliferation. CRS pathogenesis might be especially related to the RAGE overexpression correlated with disease severity and allergy.

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Section: Methodsmentioning

confidence: 99%

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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show abstract

“…This well known tomography score owes its popularity to a user-friendly interface and high inter-and intra-observer reproducibility. 1,2 For this reason, it was highly recommended to be used in research by the Task Force on Rhinosinusitis. 3 It was first described in 1993,4 and was divided in three different sections: a symptoms score, an endoscopic score and a tomography score.…”

Section: Introductionmentioning

confidence: 99%

Rhinosinusitis in autologous and allogeneic bone marrow transplantation: a retrospective study on the performance of imaging studies on severity and prognostic evaluation

Sekine¹,

Manica²,

Piltcher³

et al. 2010

Rev. Bras. Hematol. Hemoter.

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“…In the study, CT findings from 1840 patients with CRS were reviewed and the results were consistent with the above mentioned studies. In this study, a small but significant association between CT scores and postoperative improvement on the SNOT-22 was found, which indicates that patients with lower preoperative CT scores benefit more from surgical treatment (Hopkins et al, 2007).…”

Section: Imaging Methodsmentioning

confidence: 55%

Rhinosinusitis - Its Impact on Quality of Life

Schalek¹

2011

Peculiar Aspects of Rhinosinusitis

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The Lund‐Mackay staging system for chronic rhinosinusitis: How is it used and what does it predict?

Abstract: This demonstrates the strengths and limitations of a commonly used staging system.

Cited by 450 publications

References 26 publications

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Rhinosinusitis in autologous and allogeneic bone marrow transplantation: a retrospective study on the performance of imaging studies on severity and prognostic evaluation

Rhinosinusitis - Its Impact on Quality of Life

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