The lung as the main target organ in the acute phase of transfusion reaction in sheep

Halmagyi, D; Starzecki, B.; McRae, James; Horner, G. J.

doi:10.1016/s0022-4804(63)80043-8

Cited by 24 publications

(3 citation statements)

References 29 publications

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“…Pulmonary hemodynamic changes (pulmonary hypertension, hypoxemia, increased flow of lung lymph) are prominent during transfusion reaction in sheep (Halmagyi et al, 1963;Staub, 1970). Findings parallel hemodynamic changes, as observed after intravenous latex-particle administration, and may reflect increased secretion of bioactive lipids by PIMs (Albertine and Staub, 1986).…”

Section: Secretory Properties Of Pimsmentioning

confidence: 71%

Pulmonary intravascular macrophages in domestic animal species: Review of structural and functional properties

Winkler

1988

Am. J. Anat.

155

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In dogs, laboratory animals, and man, the clearance of bacteria and particulates from blood occurs predominantly in hepatic Kupffer cells and splenic macrophages. In contrast, removal of blood-borne particulates in calves, sheep, goats, cats, and pigs occurs predominantly in pulmonary intravascular macrophages (PIMs). Review of recent studies indicates that PIMs are a resident cell population, junctionally adherent to the capillary endothelium of lungs and morphologically similar to hepatic Kupffer cells. PIMs are a pulmonary constituent of the mononuclear phagocyte system with respect to secretory, endocytic, and functional properties. Differentiated PIMs are rare in newborn pigs, and the majority of cells closely apposed to capillary endothelium consists of monocytes, which are occasionally in mitosis. In 7-day-old and older pigs, most cells apposed to capillary endothelium have characteristics of differentiated PIMs. This suggests a monocytic origin of PIMs in pigs. Perinatal colonization of lung capillaries by monocytes and their subsequent differentiation into PIMs represent a component of postnatal lung development. Estimates of relative PIM numbers in ovine and porcine lung parenchyma suggest cell densities similar to that of rat hepatic Kupffer cells. Apart from phagocytic properties, PIMs participate in the removal and disintegration of aged and impaired blood cells. After phagocytic stimulation, isolated PIMs secrete oxygen radicals, which are essential for microbicidal function. Similarly, by secreting bioactive lipids, stimulated PIMs may contribute to regulation of pulmonary hemodynamics. After receiving minute amounts of bacterial endotoxin, pulmonary injury is pronounced in sheep, calves, pigs, and cats, but not in laboratory animals and dogs. This presumably is related to the secretion of bioactive lipids by PIMs.

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Section: Secretory Properties Of Pimsmentioning

confidence: 71%

Pulmonary intravascular macrophages in domestic animal species: Review of structural and functional properties

Winkler

1988

Am. J. Anat.

155

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“…Since minor incompatibility (not readily detected by routine methods) may already produce pulmonary hypertension and compliance fall in sheep, 8 only those experiments were included in this series in which opening of the anastomotic flow was not followed by pulmonary hypertension or irreversible fall in lung compliance.…”

Section: Criteria Of Cross Circulationmentioning

confidence: 99%

Humoral Transmission of Cardiorespiratory Changes in Experimental Lung Embolism

Halmagyi

Starzecki²,

Horner

1964

Circulation Research

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•Acute pulmonary microembolism causes pulmonary vasoconstriction and closure of the terminal airways. We have given reasons to suppose that these effects are not entirely explicable in terms of mechanical obstruction or neurogenic vasoconstriction and we have postulated that the effects of microembolism may be due, in part, to release of some humoral agent.1 "3 The experiments described below were designed to test this hypothesis. Methods MATERIALFourteen technically satisfactory experiments were carried out on 14 pairs of sheep. Members of each pair will be referred to as recipient (A) and donor (B). The mean weight of the recipients (A) was 33.6 kg and that of the donors (B) was 35.0 kg. OPERATIVE PROCEDURESThe supine animals were anesthetized with 10 to 15 mg/kg iv of pentothal sodium (Thiopentone) followed by an intravenous drip of 0.20 to 0.25 mg/kg/min pentothal sodium and 0.15 to 0.20 mg/kg/min heparin given in saline.Following anesthesia the trachea was intubated with a cuffed Magill tube. Catheterization of the pulmonary artery was carried out via a femoral vein and the femoral artery was cannulated. A needle was inserted into the intrapleural space and a small (60 to 100 ml) pneumothorax was induced. Rectal temperature was measured with a thermometer. PRESSURE MEASUREMENTSFemoral arterial, pulmonary arterial, intrapleural, and (whenever a double-lumen catheter was

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“…Ovine (sheep) models have been applied to the study of blood banking and transfusion medicine since the 1960s . This review discusses how new knowledge on sheep haematology and blood products make them an even more effective model for in vivo transfusion studies.…”

Section: Introductionmentioning

confidence: 99%

Lessons from sheep models of transfusion

Fung

Šimonová

Tung

2016

ISBT Science Series

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Background Animal models have been a valuable tool for research into blood products and outcomes of blood transfusions. Small animal models have been applied extensively and large animal models less frequently. This review describes the experience and details the findings from a recent series of in vivo sheep transfusion models. Aims & Method To discuss: (i) the benefits of sheep as a large animal transfusion model; and (ii) review conclusions from a series of sheep transfusion models. Results & Discussion Similarities in size, anatomy and physiology of sheep compared to humans have supported the use of sheep to model a wide range of human diseases, enabled continuous physiological monitoring using standard human techniques, and the collection of multiple and serial samples. Conclusion The findings discussed demonstrate that sheep are effective models of the blood donor, donations and of transfusion recipients. Importantly, they also define limitations of ovine models, which need to be considered when designing in vivo sheep models of transfusion.

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The lung as the main target organ in the acute phase of transfusion reaction in sheep

Cited by 24 publications

References 29 publications

Pulmonary intravascular macrophages in domestic animal species: Review of structural and functional properties

Pulmonary intravascular macrophages in domestic animal species: Review of structural and functional properties

Humoral Transmission of Cardiorespiratory Changes in Experimental Lung Embolism

Lessons from sheep models of transfusion

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