The Magnesium Connection: Impact on Erectile Dysfunction and Mortality

Abstract

This research examines both the cross-sectional and longitudinal relationships between magnesium depletion score (MDS) and erectile dysfunction (ED), as well as all-cause mortality in individuals diagnosed with ED. The analysis utilized data from the National Health and Nutrition Examination Survey (NHANES). To evaluate the correlation between MDS and ED, along with mortality outcomes, weighted multivariate regression and Cox proportional hazards models were employed. Out of the total 3,917 participants, 1,090 were identified as having ED, and 654 individuals succumbed to all-cause mortality. After controlling for potential confounding variables, it was found that each incremental increase of one point in MDS correlated with a 37% heightened risk of developing ED (OR: 1.37, 95% CI: 1.16–1.62). Furthermore, among those with ED, a greater MDS score was linked to a 30% elevation in the risk of all-cause mortality (HR: 1.30, 95% CI: 1.17–1.45). Sensitivity analyses, which included subgroup evaluations and propensity score matching (PSM), validated the robustness of these results. The findings indicate a significant association between MDS and both the prevalence of ED and the risk of all-cause mortality in individuals suffering from ED, highlighting the critical role of magnesium status in the health of men.