The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus

Pappa, Kalliopi I.; Gazouli, Maria; Anastasiou, Eleni; Iliodromiti, Zoe; Antsaklis, A.; Anagnou, Nicholas P.

doi:10.1016/j.diabres.2012.10.015

Cited by 49 publications

(35 citation statements)

References 18 publications

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“…This was shown to be a primarily pancreatic effect as pancreas-specific BMAL1 KO mice exhibit the full diabetic phenotype [24]. A recent human study demonstrated that two SNPs in the BMAL1 gene were associated with an increased risk for gestational diabetes mellitus in Greek women [26]. These SNPs were associated with lower mRNA expression of BMAL1 and were located within the intronic region of Bmal1 between the second and third exon and the fifth and sixth exon.…”

Section: Bmal1: Role Of Nitric Oxide and The Vasculaturementioning

confidence: 99%

Clock genes in hypertension

Richards

Diaz²,

Gumz

2014

Blood Pressure Monitoring

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The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has implicated the circadian clock genes in the regulation of processes in the heart, kidney, vasculature, and the metabolic organs, which are all critical in the regulation of the blood pressure. The goal of this review is to provide an introduction and general overview into the role of circadian clock genes in the regulation of blood pressure with a focus on their deregulation in the etiology of hypertension. This review will focus on the core circadian clock genes CLOCK, BMAL1, Per, and Cry.

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Section: Bmal1: Role Of Nitric Oxide and The Vasculaturementioning

confidence: 99%

Clock genes in hypertension

Richards

Diaz²,

Gumz

2014

Blood Pressure Monitoring

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“…Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene also known as Bmal1 and plays a key role as one of the positive elements in the mammalian autoregulatory transcription translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity (Pappa et al 2013;Richards et al 2014) and mutations in Bmal1 have been linked to infertility, gluconeogenesis. BMAL1 binds with a second bHLH-PAS protein via the PAS domain, CLOCK to form a heterodimer in the nucleus (Huang et al 2012).…”

Section: Combined and Non-hormonal Actions Of Srcsmentioning

confidence: 98%

Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Pecenova

Farkas

2016

Endocrine Regulations

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Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a large superfamily of transcription factors that participate virtually in every key biological process. They control various aspects of animal development, fertility, gametogenesis, and numerous metabolic pathways, and can be misregulated in many types of cancers. Their enormous functional plasticity, as transcription factors, relates in part to NR-mediated interactions with plethora of coregulatory proteins upon ligand binding to their ligand binding domains (LBD), or following covalent modification. Here, we review some general views of a specific group of NR coregulators, so-called nuclear receptor coactivators (NRCs) or steroid receptor coactivators (SRCs) and highlight some of their unique functions/roles, which are less extensively mentioned and discussed in other reviews. We also try to pinpoint few neglected moments in the cooperative action of SRCs, which may also indicate their variable roles in the hormone-independent signaling pathways.

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“…Circadian desychronization caused faster onset of diabetes in the Type 1 diabetic HIP rat model; these rats overexpress the human islet amyloid polypeptide, which leads to pancreatic ␤ cell failure (43). One study demonstrated that two SNPs in the Bmal1 gene were associated with an increased risk for gestational diabetes mellitus in Greek women (102). Transcriptomic analysis of pancreatic islets from healthy and Type 2 diabetics demonstrated that Per2-3 and Cry2 were downregulated in people with Type 2 diabetes (132).…”

Section: Metabolismmentioning

confidence: 99%

Mechanism of the circadian clock in physiology

Richards

Gumz

2013

American Journal of Physiology-Regulatory, Integrative and Comp

123

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It has been well established that the circadian clock plays a crucial role in the regulation of almost every physiological process. It also plays a critical role in pathophysiological states including those of obesity and diabetes. Recent evidence has highlighted the potential for targeting the circadian clock as a potential drug target. New studies have also demonstrated the existence of "clock-independent effects" of the circadian proteins, leading to exciting new avenues of research in the circadian clock field in physiology. The goal of this review is to provide an introduction to and overview of the circadian clock in physiology, including mechanisms, targets, and role in disease states. The role of the circadian clocks in the regulation of the cardiovascular system, renal function, metabolism, the endocrine system, immune, and reproductive systems will be discussed.

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The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus

Cited by 49 publications

References 18 publications

Clock genes in hypertension

Clock genes in hypertension

Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Mechanism of the circadian clock in physiology

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