The MALDI-TOF Mass Spectrometric View of the Plasma Proteome and Peptidome

Hortin, Glen L.

doi:10.1373/clinchem.2006.069252

Cited by 328 publications

(255 citation statements)

References 117 publications

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“…These enzymes can modify, in a specific manner, the serum proteins (proteome) and their metabolic products, i.e., peptides (peptidome; for a review of plasma peptidome see refs. [119] and [120]). Thus, both the proteases and the serum peptidome can be considered as potential biomarkers of the disease.…”

Section: Searching Of Novel Cardiovascular Biomarkers In Plasma Proteomementioning

confidence: 99%

Vascular proteomics

Vivanco

Mas

Dardé

et al. 2007

Proteomics Clinical Apps

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The characterization of patients with acute coronary syndromes (ACS) at the molecular and cellular levels provides a novel vision for understanding the pathological and clinical expression of the disease. Recent advances in proteomic technologies permit the evaluation of systematic changes in protein expression in many biological systems and have been extensively applied to cardiovascular diseases (CVD). The cardiovascular system is in permanent intimate contact with blood, making blood-based biomarker discovery a particularly worthwhile approach. Thus, proteomics can potentially yield novel biomarkers reflecting CVD, establish earlier detection strategies, and monitor response to therapy. Here we review the different proteomic strategies used in the study of atherosclerosis and the novel proteins differentially expressed and secreted by atherosclerotic lesions which constitute novel potential biomarkers (HSP-27, Cathepsin D). Special attention is paid to MS-Imaging of atheroma plaque and the generation, for the first time, of 2-D images of lipids, showing the distribution of these molecules in the different areas of the atherosclerotic lesions. In addition new potential biomarkers have been identified in plasma (amyloid A1a, transtherytin), circulating cells (protein profile in monocytes from ACS patients) and individual cells constituents of atheroma plaques (endothelial, VSMC, macrophages) which provide novel insights into vascular pathophysiology.

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Section: Searching Of Novel Cardiovascular Biomarkers In Plasma Proteomementioning

confidence: 99%

Vascular proteomics

Vivanco

Mas

Dardé

et al. 2007

Proteomics Clinical Apps

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“…Современным направлением в терапии миастении счита-ют применение препаратов с антиоксидантным действи-ем, к числу которых можно отнести меглюмина натрия сукцинат (Реамберин). Проведение протеомного анализа крови у пациентов с миастенией поможет установить молекулярные звенья механизма развития миастении и разработать эффективную терапию [21].…”

Section: научные сообщения введениеunclassified

The Study of Dynamics of Clinical and Molecular Phenotypes in the Generalized Form of Myasthenia With Optimized and Combined Treatment

Дрозд¹,

Ефремов²,

Романцов³

et al. 2013

ARAMS

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“…It has even been used for the direct analysis of tissue specimens [30] . In MALDI-TOF MS, a small quantity of specimen containing peptides and protein is dried on a target plate together with a lightabsorbing matrix molecule.…”

Section: Bitarte N Et Al Proteomic In Colorectal Cancermentioning

confidence: 99%

Moving forward in colorectal cancer research, what proteomics has to tell

Bitarte

Bandrés²,

Zarate³

et al. 2007

WJG

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Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer.

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The MALDI-TOF Mass Spectrometric View of the Plasma Proteome and Peptidome

Cited by 328 publications

References 117 publications

Vascular proteomics

Vascular proteomics

The Study of Dynamics of Clinical and Molecular Phenotypes in the Generalized Form of Myasthenia With Optimized and Combined Treatment

Moving forward in colorectal cancer research, what proteomics has to tell

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