The Management Challenges in an Unusual Case of Primary Osteosarcoma of the Rib in an Adult Patient

Abstract

Primary osteosarcomas are derived from primitive bone-forming mesenchymal stem cells and most often originate in the metaphysis of the long bones of children and adolescents, but it occurs very rare in adults. Approximately 10% of osteosarcomas are located in the flat bones, pelvis being the main site. Involvement of flat bones like rib may be seen as a metastatic process or secondary to chemotherapy, but a primary osteosarcoma rib is extremely rare. Osteosarcoma originating from such rare sites poses numerous diagnostic and therapeutic challenges, and we report one such case in a 24-year-old male patient. Our case highlights the fact that osteosarcoma of the rib, although rare, should be considered in the differential diagnosis of primary malignant neoplasms of the rib even in the adult population. Further, early prompt diagnosis and aggressive multimodality management are cornerstones of management and will help improve the survival outcomes.

The potential value of lncRNA-BC050642 in osteosarcoma origination and outcomes

“…C-myc expression was significantly higher in cells transfected with pcDNA3.1-c-myc than those transfected with empty vector (pcDNA3.1) ( Ã p < .05 represented the significant difference between the compared two). [22]. Cure rate is < 65% for localized osteosarcoma patients, while cases showing metastasis when diagnosed frequently experience poorer prognosis [23].…”

Radical resection of a giant rib osteosarcoma with complex chest wall reconstruction

“…In our literature review, the largest reported POSR was 20 × 15 cm requiring resection of ribs 5, 6, and 7, which was reconstructed with a latissimus flap [17]. Lim et al resected a 9 × 13 cm mass with five contiguous ribs (ribs 3–7) and reconstruction with titanium mesh [18].…”

An unusual occurrence of giant primary osteosarcoma of chest wall in adult: case report and review of literature

“…Primary malignant bone tumours of the chest wall are very rare entity. 1,2 Of these tumours chondrosarcomas are the most frequent. 2 These are mainly low-grade.…”

“…Osteosarcoma is one of the most frequent bone sarcomas occurring primarily in metaphysis of long bones. 1,2 The most age group affected in adolescence though it rarely might occur in adults. Osteosarcoma less frequently affects the flat bones of the body, of which pelvic bones are most commonly affected.…”

“…Chest wall involvement is exceedingly rare by a primary osteosarcoma. 1,2,3 These pose a unique diagnostic and management challenge to the clinician. We here describe a rare occurrence of a huge chest wall osteosarcoma in 22 year adult patient.…”