The marine Omega3 wound matrix for treatment of complicated wounds

Dorweiler, Bernhard; Trinh, T. T.; Dünschede, F.; Vahl, Christian F.; Debus, Eike Sebastian; Storck, M.; Diener, Holger

doi:10.1007/s00772-018-0428-2

Cited by 45 publications

(46 citation statements)

References 20 publications

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“…In the human body, ω3 are precursors of signaling molecules that are important for: re-establishing homeostasis and resolution in chronic wounds; host defense, pain, and tissue remodeling; (Serhan, 2014) inducing anti-inflammatory and pro-resolving signaling pathways; and combating various microbes (Maderna and Godson, 2009). Additionally, in a randomized, double-blind clinical trial, ω3 application in wound care has promoted significantly faster healing while in recent case studies ω3 application has also reduced the need for use of analgesic medication (Yang et al, 2016; Dorweiler et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Costa

Ribeiro

Machado

et al. 2019

Front. Bioeng. Biotechnol.

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Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to leak from the application site, thus showing reduced ability to sustain local drug residence. This work reports on the production of poly (ε-caprolactone) (PCL) fibrous matrices with ACV and omega-3 fatty acids (ω3) for application as dressings to the topical treatment of orofacial herpes. PCL fibrous matrices with the co-incorporated bioactive compounds were obtained by electrospinning and characterized regarding their morphology, chemical, physical, and mechanical properties. The potential use of the developed polymeric fibrous matrices for topical applications was evaluated by: (i) the release kinetics of the bioactive compounds; (ii) the occlusive factor of the fibrous mat; (iii) ACV skin permeation capacity; and (iv) the cytotoxicity in a keratinocyte cell line. PCL fibrous matrices loaded with the bioactive compounds presented a smooth morphology and a good balance between flexibility and hardness essential to be durable for handling, while having a desirable texture to be used comfortably. The fibrous mat also provided a sustained release of ACV during 96 h and improved the skin permeability of this drug (Kp = 0.00928 ± 0.000867 cm/h) presenting also high porosity (74%) and a water vapor transmission rate (WVTR) of 881 ± 91 g/m2day, essential to maintain moist and oxygen for faster healing of herpes lesions. Furthermore, cytotoxicity studies suggest that the fibrous mat are safe for topical application. Overall, the PCL based electrospun fibrous matrices with ACV and ω3 hereby described have the potential to be used as therapeutic bandage systems for the treatment of orofacial herpes.

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Section: Discussionmentioning

confidence: 99%

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Costa

Ribeiro

Machado

et al. 2019

Front. Bioeng. Biotechnol.

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“…However, the cost of Kerecis is relatively low compared to other ADMs. Kerecis, a newly-approved ADM, is a piscine acellular dermal xenograft, which is derived from the Atlantic cod (Gadus morhua) [10,11]. Fish skin shows architectural similarities to mammalian skin, owing to its molecular structure [9,10,12].…”

Section: Discussionmentioning

confidence: 99%

“…Kerecis, a newly-approved ADM, is a piscine acellular dermal xenograft, which is derived from the Atlantic cod (Gadus morhua) [10,11]. Fish skin shows architectural similarities to mammalian skin, owing to its molecular structure [9,10,12]. Kerecis maintains its three-dimensional structure composed of glycosaminoglycans, proteoglycans, fibronectin, and growth factors [9].…”

Section: Discussionmentioning

confidence: 99%

“…Kerecis maintains its three-dimensional structure composed of glycosaminoglycans, proteoglycans, fibronectin, and growth factors [9]. These lipid mediators are also preserved through the special manufacturing process of Kerecis [10]. Furthermore, the product has specific bioactive lipid mediators called omega-3 polyunsaturated fatty acids, which are a distinct feature of piscine ADM.…”

Section: Discussionmentioning

confidence: 99%

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The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

et al. 2021

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Background: The newly-approved Kerecis is a piscine acellular dermal xenograft. This piscine acellular dermal matrix (ADM) has specific bioactive lipid mediators, omega-3 polyunsaturated fatty acids, and has a positive effect on the process of wound healing. This study aimed to explore the utility of this novel material by comparing healing rates, and suggest the proper timing for applying Kerecis.<br/>Methods: Patients who visited the hospital with acute or chronic deep dermal wounds from June 2019 to May 2020 were enrolled in the study. A total of 48 patients were assessed. All wounds in the experimental group (n=16) were treated only once with Kerecis and a non-adherent absorptive foam material (Therasorb) to cover the ADM. In the control group, daily conventional dressings were provided. All wounds sizes were measured with mass-market computer software in a method suggested by the authors for the first time.<br/>Results: The mean healing rate proved to be faster in the Kerecis group (P<0.05) versus the control group, and no complications were observed. It was statistically proved that treating burn wounds with the ADM showed better healing rates than the conventional method (P<0.05).<br/>Conclusion: This study establishes that managing wounds with the ADM is likely to heal wounds faster than traditional dressings. In addition, for burn wounds, a prolonged application (10 days vs. 5 days after the onset) showed a better wound healing rate (98.8%±2.5% vs. 67.0%±14.3%, respectively, P=0.029).

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“…The thickness of fish skin may contribute to its enhanced bacterial barrier properties when compared with thinner biological grafting materials, derived from the lining of internal organs. Perhaps most importantly, cold water fish is known to be rich in omega‐3 polyunsaturated fatty acids (PUFAs; Cholewski, Tomczykowa, & Tomczyk, ; Osman, Jaswir, Khaza'ai, & Hashim, ), and this may contribute to its properties of reducing local inflammation and promoting angiogenesis (Magnusson et al, ), thus supporting wound healing with concomitant pain relief and reduced scarring (Baldursson et al, ; Dorweiler et al, ).…”

Section: Introductionmentioning

confidence: 99%

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

Kotronoulas

Jónasdóttir

Sigurðardóttir

et al. 2020

J Tissue Eng Regen Med

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Acellular fish skin (ACS) has emerged as a dermal substitute used to promote wound healing with decreased scar formation and pain relief that may be due to polyunsaturated fatty acid (PUFA) content. However, the PUFA content of ACS is still unknown. The aim of this study was to compare the total fatty acids and lipid profiles of ACS to two bovine‐based grafts and standard of care human cadaver skin (HCS). Furthermore, there was also the goal to assess the capability of ACS lipid content to enhance wound healing. The fatty acid analysis was performed with GC–FID, and an LC–MS untargeted method was developed in order to the analyse the lipid profiles of the grafts was. The enhancement of wound healing by the ACS extract was investigated in vitro on HaCat cells. Our results showed that ACS had the highest content of PUFA (27.0 ± 1.43% of their total fatty acids), followed by HCS (20.6 ± 3.9%). The two grafts of bovine origin presented insignificant PUFA amounts. The majority of the PUFAs found in ACS were omega‐3, and in HCS, they were omega‐6. The untargeted lipidomics analysis demonstrated that ACS grafts were characterized by phosphatidylcholine containing either 20:5 or 22:6 omega‐3 PUFA. The ACS lipid extract increased the HaCat cells migration and enhanced wound closure 4 hr earlier versus control. Our study demonstrated that ACS has a lipid profile that is distinct from other wound healing grafts, that PUFAs are maintained in ACS post‐processing as phosphatidylcholine, and that ACS lipid content influences wound healing properties.

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The marine Omega3 wound matrix for treatment of complicated wounds

Cited by 45 publications

References 20 publications

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

Wound healing grafts: Omega‐3 fatty acid lipid content differentiates the lipid profiles of acellular Atlantic cod skin from traditional dermal substitutes

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