The “Master Code of DNA”: Towards the Discovery of the SNPs Function (Single-Nucleotide Polymorphism)

Pérez, José María Hernández

doi:10.21767/2472-1158.100060

Cited by 12 publications

(14 citation statements)

References 3 publications

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“…In (Perez, 2015 andPerez, 2018), we present a unifying theoretical method, from the atomic masses of their bioatoms C O N H S P, the 3 biological universes of RNA, DNA and proteins. We published various articles involving applications based on this basic research (Perez, 2017b, Perez, 2017c.…”

Section: S:d80ymentioning

confidence: 99%

“…They allow a simple numerical translation of the 64 codons and 20 amino acids. Exposing here the concepts leading to this code goes beyond the scope of this article and we refer the budding mathematicians to the article (Perez, 2018) "Six Fractal Codes of Biological Life: perspectives in Exobiology and Artificial Intelligence Biomimetism Decisions Making, 2018". One could oppose the criticism that this representation reduces too drastically the physico-chemical reality of the translated sequences.…”

Section: S:d80ymentioning

confidence: 99%

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SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Pérez¹

2021

Preprint

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In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and « 2 mutations » IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. 9/ Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? Particularly, we suggest the following conjecture at mRNA folding level : CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.. Particularly, using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the 2 vaccines Moderna and Phizer, we conclude a very probable difference in stability and shelf life of the 2 respective mRNAs of these 2 vaccines. However, the “State of the Art” will tell you that their 2 protein sequences are strictly identical. However, by having modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the 2 cases. We can only note the great ADAPTATION power - at the global scale of their genomes - of the most infectious VARIANTS such as the BRAZIL 20J / 501Y.V3 variant (P.1). This is very worrying for the VACCINES <==> VARIANTS run: We demonstrate how the Brazilian variant P.1 which becomes uncontrollable in Brazil in April 2021 has a level of organization of long metastructures of 17,711 bases covering the genome which is 3.6 more important than that of the 2 reference genomes SARS-CoV2 Wuhan and worldwide D614G. We suggest that this high level of overall structure of this variant contributes to the stability of this genome and, possibly, to its greater contagiousness.

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Section: S:d80ymentioning

confidence: 99%

Section: S:d80ymentioning

confidence: 99%

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Pérez¹

2021

Preprint

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“…In [5,39,[40][41][42][43][44][45][46][47][48][49] we will present other "hidden mathematical codes" that organize the DNA sequences of the human genome.…”

Section: Dmentioning

confidence: 99%

Neuroblastoma and Glioblastoma Brain Cancers: «Human Genome Optimum» (HGO) a Global Genome Strategy controlling all Human Chromosome LOH Deletions

Perez

2018

NACS

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BackgroundThanks to the CRISPR (Clustered regularly interspaced short palindromic repeats) technology, it is now possible to locally modify the genomes, and particularly the human genome [1]. Almost simultaneously, the fractal and global structures of the human genome were demonstrated [2]. In such a context, apart from ethical questions, can a local technology as powerful as CRISPR be applied, ignoring its possible effect on the possible global and long-range equilibria and balancing at the chromosome scale or even the entire genome scale? For more than 25 years, we have been looking for possible global, even numerical, structures that would organize DNA, genes, chromosomes and even whole genomes [3][4][5][6]. Curiously, the method of numerical analysis of whole genomes as well as the discovery of a global law of impact of the LOH deletions associated with tumors that will be the subject of | this article may seem to the reader too simple or even "naive"... In effect, these laws are based on a well-known type of analysis that could be thought to have explored all aspects: the analysis of GC/TA ratios. It has long been known that such ratios [7] characterize the diversity of chromosomes. Under the name of "isochores," Giorgio Bernardi has extensively explored its richness and diversity [8,9]. We have already demonstrated a numerical structure at the scale of each human chromosome as well as on the whole genome [10][11][12][13]. In [10] we have already highlighted this numerical value of 0.6909830056, the HGO in this article: it controls the population of triplet's codons analysing single stranded DNA sequence from the whole human genome. However, it is only by deepening the notion of "fractal periodicity", outlined in [14], and we will highlight in various articles in preparation [15] that we have re-discovered

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“…This law, "the Master Code of Biology" is published in 2009 in the book Codex Biogenesis [3] and then in 2015 in a reference article peer review [4]. In 2017 we publish different applications: HIV, SNPs, brain genetics [5][6][7][8]. On the other hand, at the beginning of the 2000s we studied the integrity of the Prions proteins showing common invariant bi-attractors in "W", while the Amyloid was characterized by a pattern in "V" shape.…”

Section: Introductionmentioning

confidence: 99%

The “Master Code of DNA”: Towards the Discovery of the SNPs Function (Single-Nucleotide Polymorphism)

Cited by 12 publications

References 3 publications

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Neuroblastoma and Glioblastoma Brain Cancers: «Human Genome Optimum» (HGO) a Global Genome Strategy controlling all Human Chromosome LOH Deletions

The Master Code of Biology: Self-assembly of two identical Peptides beta A4 1-43 Amyloid In Alzheimer’s Diseases

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