The MATEX cohort – a Finnish population register birth cohort to study health effects of prenatal exposures

Rumrich, Isabell; Vähäkangas, Kirsi; Viluksela, Matti; Gissler, Mika; Surcel, Heljä‐Marja; Ruyter, Hanna de; Jokinen, Jukka; Hänninen, Otto

doi:10.1186/s12889-017-4881-8

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The MATEX cohort was identified from the Finnish Medical Birth Register. It is described in more detail elsewhere 10. The Finnish Medical Birth register contains perinatal outcomes, pregnancy characteristics and sociodemographic information for all live births and stillbirths after the 22nd gestational week or with a birth weight of at least 500 g. The Medical Birth Register receives information from standardised forms filled out by nurses and midwives during antenatal care visits and after the delivery of the baby.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, we studied how growth restriction associated with maternal smoking contributes to abnormal body proportions. For this, we used the MATEX cohort identified from the Finnish Medical Birth Register 10. Additionally, we discuss the possibility of mechanistic interpretations of differences in body proportions in newborns of smoking mothers compared with non-exposed newborns.…”

Section: Introductionmentioning

confidence: 99%

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Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births

et al. 2020

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ObjectivesThe aim of our work was to analyse the effect of maternal smoking on body size and body proportions of newborns when the mother had smoked only during the first trimester, in comparison with continued smoking after the first trimester. Furthermore, we have evaluated how growth restriction associated with maternal smoking contributes to changes in body proportions.DesignRegister-based cohort studySettingMaternal Exposure (MATEX) cohort identified from the Finnish Medical Birth Register.ParticipantsSingleton births without congenital anomalies and missing data (1.38 million) from 1 January 1991 to 31 December 2016.MethodsLogistic regression was used to quantify the effect of maternal smoking, stratified by the maternal smoking status.Outcome measuresBody proportions indicated by low brain-to-body ratio (defined as <10th percentile); high ponderal index and high head-to-length ratio (defined as >90th percentile); small body size for gestational age at birth (defined as weight, length or head circumference <10th percentile) and preterm birth (<37 weeks) and low birth weight (2500 g).ResultsContinued smoking after the first trimester was associated with high ponderal index (OR 1.26, 95% CI 1.23 to 1.28), low brain-to-body ratio (1.11, 1.07–1.15) and high head-to-length ratio (1.22, 1.19–1.26), corresponding with absolute risks of 22%, 10% and 19%, respectively). The effects were slightly lower when smoking had been quit during the first trimester. Similar effects were seen for the body size variables and low birth weight. Preterm birth was not associated with smoking only during first trimester.ConclusionsMaternal smoking, independent of smoking duration during pregnancy, was associated with abnormal body proportions resulting from larger reduction of length and head circumference in comparison to weight. The effects of having quit smoking during the first trimester and having continued smoking after the first trimester were similar, suggesting the importance of early pregnancy as a sensitive exposure window.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births

et al. 2020

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“…Our work focused on the qualitative data from 1991 to 2015 ( N =1,435,009). The cohort has been described in detail elsewhere [17].…”

Section: Methodsmentioning

confidence: 99%

Smoking during pregnancy in Finland – Trends in the MATEX cohort

Rumrich

Vähäkangas

Gissler

et al. 2018

Scand J Public Health

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Aims: In Finland, smoking rates in the general population are decreasing due to increased awareness of the adverse effects and tightened tobacco legislation. However, previous studies have shown that smoking in pregnant Finnish women remained as high as in the general Finnish female population at around 15% in 2010. Our aim was to describe temporal and spatial trends in smoking behaviour, and determinants of changes in smoking behaviour between first and second pregnancy. Methods: Self-reported smoking from the Finnish Medical Birth Register covered the years 1991–2015 ( N=1,435,009). The association of maternal age and socioeconomic status with smoking rate was analysed. Spatial trends were assessed at municipality level. Results: The overall smoking rate during early pregnancy remained fairly stable at around 15% from 1991 to 2015, but increased in teenage and young women below 25 years of age. The mean smoking rate (36%) was higher in these age groups than in older pregnant women (11%). Through the study period the smoking rate remained higher in blue collar workers compared with higher socioeconomic groups. Between the first and second child, on average only 4% of women started to smoke and 41% quitted. Smoking rates developed less favourably in Eastern Finland. Conclusions: The observed increase in smoking rate during pregnancy in teenage and young women is concerning. Pregnancy is a trigger point for smoking cessation in a big fraction of pregnant women. More studies are needed to explain the opposite trends of smoking rates in Northern and Western Finland compared with Eastern Finland.

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“…The birth cohort analyzed in this work has been investigated as part of the bigger MATEX cohort for the effects of maternal smoking [ 20 ]. Our previous work included smoking stratified by quitting during the first trimester and continued after the first trimester.…”

Section: Discussionmentioning

confidence: 99%

“…Shortly, in the MBR, information is available on the mother and her health, pregnancy complications, delivery characteristics, and the newborn’s characteristics and health. The MATEX cohort is described in more detail elsewhere [ 20 ]. Within this cohort, roughly 24,000 triads of grandmother-mother-child were identified.…”

Section: Methodsmentioning

confidence: 99%

Effect of Grandmaternal Smoking on Body Size and Proportions at Birth

Rumrich

Hänninen

Viluksela

2021

IJERPH

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Many long-term adverse effects of smoking during pregnancy are known. Increasingly, adverse effects in the grandchild after grandmaternal smoking during pregnancy are reported. We explored this in a birth cohort of 24,000 grandmother–mother–child triads identified from the Finnish Medical Birth Register in 1991–2016. Multiple logistic regression was used to analyze the association between any smoking during pregnancy by both grandmother and mother, or only grandmother or mother on adverse birth outcomes. No smoking by neither grandmother nor mother was used as the reference. As endpoints, preterm birth, low birth weight, small for gestational age (birth weight, birth length, head circumference), and body proportionality (low ponderal index, high brain-to-body ratio, high head-to-length ratio) were included. Smoking by both grandmother and mother was consistently associated with higher risks than smoking only by the mother. Birth length and weight were especially sensitive to (grand)maternal smoking. In conclusion, the combined effect of grandmaternal and maternal smoking is associated with higher risks than only maternal smoking.

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The MATEX cohort – a Finnish population register birth cohort to study health effects of prenatal exposures

Cited by 5 publications

References 36 publications

Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births

Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births

Smoking during pregnancy in Finland – Trends in the MATEX cohort

Effect of Grandmaternal Smoking on Body Size and Proportions at Birth

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