The MATRICS Consensus Cognitive Battery, Part 2: Co-Norming and Standardization

Kern, Robert S.; Nuechterlein, Keith H.; Green, Michael F.; Baade, Lyle E.; Fenton, Wayne S.; Gold, James M.; Keefe, Richard S.E.; Mesholam-Gately, Raquelle I.; Mintz, Jim; Seidman, Larry J.; Stover, Ellen; Marder, Stephen R.

doi:10.1176/appi.ajp.2007.07010043

Cited by 637 publications

(494 citation statements)

References 23 publications

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“…Social cognition was assessed using the "Managing Emotions" section of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) [41] , which is recommended by the US National [41][42][43][44][45] .…”

Section: Neurocognitive/psychopathology Assessmentmentioning

confidence: 99%

Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study

et al. 2013

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People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia.

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Section: Neurocognitive/psychopathology Assessmentmentioning

confidence: 99%

Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study

et al. 2013

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“…The result of these research efforts was to develop within a research program MATRICS a standardized, approved by the FDA (U.S. Food and Drug administation) test battery MCCB (MATRICS Consensus Cognitive Battery). This tool used for evaluating neurodegenerative dysfunctions consists of ten tests assessing seven cognitive domains: speed processing, attention / vigilance, working memory, verbal learning, visual instruction, reasoning and problem solving, and social cognition [81].…”

Section: Resultsmentioning

confidence: 99%

“…Efektem tych poszukiwań badawczych było opracowanie w ramach programu badawczego MATRICS standaryzowanej, zaakceptowanej przez FDA (U.S. Food and Drug Administation) baterii testowej MCCB (MATRICS Consensus Cognitive Battery). To narzędzie służące do oceny dysfunkcji neuropoznawczych składa się z dziesięciu testów oceniają-cych siedem domen poznawczych: szybkość przetwarzania (speed processing), uwagę/czujność, pamięć roboczą, uczenie słowne, uczenie wzrokowe, rozumowanie i rozwiązywanie problemów oraz poznanie społeczne [81].…”

Section: Wyniki I Dyskusjaunclassified

Review paper. Neuropsychological dimension of schizophrenia - evaluation possibilities and therapeutic implications

Makarewicz

Karakuła-Juchnowicz

Łobejko

2017

Current Problems of Psychiatry

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Introduction: In the last decades, researchers' attention has been focused on cognitive dysfunction in schizophrenia. Numerous studies indicate the existence of neurodegenerative deficits in schizophrenia including, but not limited to, motor functions, learning and memory, executive functions, attention, language, spatial skills and general intelligence.Method: A review of available literature on the topic of the past two decades, available in the Pubmed, EBSCO, SCOPUS databases has been made using the keywords: schizophrenia, cognition, early intervention.Results: Cognitive dysfunction is an important feature of the prodromal phase and the first episode of schizophrenia. Researchers have thus proposed to initiate early therapeutic interventions for people with so-called risky mental conditions. The article includes the reference to research on neurocognitive disorders essence in schizophrenia, the definition and review of methods used to identify specific cognitive deficits and issues related to risk of developing psychosis and early therapeutic intervention in high-risk states.Conclusions: Researchers report the importance of detecting cognitive disorders in the early stages of schizophrenia. This broadens the range of therapeutic interventions and enables early intervention in the increased risk of psychosis.

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“…*** Represents values outside of 3 SD from the mean of the controls. $ Normative data associated with the MCCB is stratified by education in addition to age and gender (Kern et al, 2008). %Percentiles derived from Z scores calculated using averages and standard deviations from (age stratified) normative data (Benedict et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 20-25 min later, a delayed recall trial and a recognition trial are completed. The stratified normative data associated with the MCCB was used in the current study, which allowed for the calculation of T scores for the composite recall index from within age-, gender-, and educationappropriate strata [18]. For all of the other indices (i.e.…”

Section: Hopkins Verbal Learning Testmentioning

confidence: 99%

A Neurocognitive Assessment of a Patient with Body Integrity Identity Disorder

Sumner¹,

Castle²,

Kaplan³

et al. 2015

Int J Clin Case Stud

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Objective: Body integrity identity disorder is characterized by a desire to obtain a physical disability, often in the form of amputation. To date, we are aware of no comprehensive investigations of neurocognition in body integrity identity disorder. Method: We report a comprehensive neurocognitive workup of an individual (Mr A), who presented with a longstanding and intense desire to amputate his left leg. Results: In comparison to four demographically matched healthy controls, Mr A exhibited impairment in working memory, with some evidence of additional difficulties with long-term memory. Conclusions: His neurocognitive weaknesses are inline with altered functioning within the superior parietal lobule, which has been implicated in the pathophysiology of body integrity identity disorder.

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The MATRICS Consensus Cognitive Battery, Part 2: Co-Norming and Standardization

Cited by 637 publications

References 23 publications

Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study

Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study

Review paper. Neuropsychological dimension of schizophrenia - evaluation possibilities and therapeutic implications

A Neurocognitive Assessment of a Patient with Body Integrity Identity Disorder

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