The matrix metalloproteinases and CNS plasticity: An overview

Milward, EA; Fitzsimmons, Chantel; Szklarczyk, Arek; Conant, Katherine

doi:10.1016/j.jneuroim.2007.04.010

Cited by 56 publications

(48 citation statements)

References 113 publications

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“…The rapid switch from embryonic and early postnatal extracellular matrices to their mature form in the normal adult CNS (Rauch 2004), the fast disappearance of CSPGs from the predestined axonal pathways observed in the developing periphery (Landolt et al 1995;Oakley and Tosney 1991), as well as the reactive changes following nervous system lesions (Galtrey and Fawcett 2007; Zurn and Bandtlow 2006) cannot solely be attributed to adjustments in the ECM expression patterns, but must also depend on highly active proteolytic processes (Agrawal et al 2008;Ethell and Ethell 2007;Flannery 2006;Gottschall et al 2005;Milward et al 2007;Porter et al 2005). The selective turnover of lecticans may in this context be essential for altering the cell migration and axon growth properties of many nervous tissues.…”

Section: Matrix Turnovermentioning

confidence: 99%

Extracellular matrix of the central nervous system: from neglect to challenge

Zimmermann

Dours-Zimmermann

2008

Histochem Cell Biol

406

340

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(aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated fiber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have significantly contributed to the increased awareness of this long time neglected structure. Abstract The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated Wber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have signiWcantly contributed to the increased awareness of this long time neglected structure.

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Section: Matrix Turnovermentioning

confidence: 99%

Extracellular matrix of the central nervous system: from neglect to challenge

Zimmermann

Dours-Zimmermann

2008

Histochem Cell Biol

406

340

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“…5) in astrocytes derived from young adults or senescent females, respectively. Matrix metalloproteinases are enzymes that target the extracellular matrix, chemokines, cytokines and growth factors (for review see Milward et al, 2007). MMP-9 activity was activated only with LPS (Fig.…”

Section: Effect Of 17β-estradiolmentioning

confidence: 99%

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats

Lewis¹,

Johnson²,

Stohlgren³

et al. 2008

Journal of Neuroimmunology

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Estrogen has been shown to attenuate the inflammatory response following injury or lipopolysaccharide treatment in several organ systems. Estrogen's actions are transduced through two estrogen receptor sub-types, estrogen receptor (ER) -alpha and estrogen receptor-beta, whose actions may be overlapping or independent of each other. The present study examined the effects of ERα-and ERβ-specific ligands in regulating the inflammatory response in primary astrocyte cultures. Pre-treatment with 17β-estradiol (ERα/ERβ agonist), HPTE (ERα agonist/ERβ antagonist) and DPN (ERβ agonist) led to attenuation of IL-1β, TNFα, and MMP-9 in astrocyte media derived from young adult (3-4 mos.) and reproductive senescent female (9-11 mos., acyclic) astrocyte cultures, while pretreatment with PPT (ERα agonist) attenuated IL-1β (but not TNFα or MMP-9) in both young and senescent-derived astrocyte cultures. Our previous work determined that 17β-estradiol was unable to attenuate the LPS-induced increase in IL-1β in olfactory bulb primary microglial cultures derived from either young adult or reproductive senescent females. In young adult-derived microglial cultures, the LPS-induced increase in IL-1β was not attenuated by pre-treatment with 17β-estradiol, PPT or HPTE. Interestingly, the ERβ agonist, DPN significantly decreased IL-1β following LPS treatment in young adult-derived microglia. Thus while both microglia and astrocytes synthesize and release inflammatory mediators, the present data shows that compounds which bind ERβ are more effective in attenuating proinflammatory cytokines in both cell types and may therefore be a more effective agent for future therapeutic use.

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“…24 These proteins are involved in a wide range of biological events including cancer cell metastasis, 25 angiogenesis, 26 tissue repair, 27 and inflammation. 28 Recent studies identified the involvement of these 2 MMPs in certain CNS diseases, 29 and their association with pain perception. 30 The purpose of the present study is to evaluate the changes in CysC and gelatinase expression in human CSF in a CP condition deriving from osteoarthritis (OA).…”

mentioning

confidence: 99%