The MDS consensus tremor classification: The best way to classify patients with tremor at present

Latorre, Anna; Hallett, Mark; Deuschl, G.; Bhatia, Kailash P.

doi:10.1016/j.jns.2022.120191

Cited by 19 publications

(23 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 84 While minor white matter abnormalities have been reported in patients diagnosed with “ET-plus,” the authors urge caution using these clinically given the lack of widespread acceptance with the diagnosis. 1 8 85 When needed, a DaT SPECT scan can efficiently distinguish between ET and PD even in the early stages of the disease, showing normal uptake of radiotracer in ET. 86…”

Section: Ancillary Investigationsmentioning

confidence: 99%

“…23,84 While minor white matter abnormalities have been reported in patients diagnosed with "ET-plus," the authors urge caution using these clinically given the lack of widespread acceptance with the diagnosis. 1,8,85 When needed, a DaT SPECT scan can efficiently distinguish between ET and PD even in the early stages of the disease, showing normal uptake of radiotracer in ET. 86 While the authors recommend the use of neurophysiology as an ancillary investigation in OT, MRI of the brain volume and cortical thickness data (right superior parietal and left thalamus areas) have been reported to accurately differentiate OT from ET.…”

Section: Role Of Neuroimagingmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Uncertainties in Tremor

2023

View full text Add to dashboard Cite

The approach and diagnosis of patients with tremor may be challenging for clinicians. According to the most recent consensus statement by the Task Force on Tremor of the International Parkinson Movement Disorder Society, the differentiation between action (i.e., kinetic, postural, intention), resting, and other task- and position-specific tremors is crucial to this goal. In addition, patients with tremor must be carefully examined for other relevant features, including the topography of the tremor, since it can involve different body areas and possibly associate with neurological signs of uncertain significance. Following the characterization of major clinical features, it may be useful to define, whenever possible, a particular tremor syndrome and to narrow down the spectrum of possible etiologies. First, it is important to distinguish between physiological and pathological tremor, and, in the latter case, to differentiate between the underlying pathological conditions. A correct approach to tremor is particularly relevant for appropriate referral, counseling, prognosis definition, and therapeutic management of patients. The purpose of this review is to outline the possible diagnostic uncertainties that may be encountered in clinical practice in the approach to patients with tremor. In addition to an emphasis on a clinical approach, this review discusses the important ancillary role of neurophysiology and innovative technologies, neuroimaging, and genetics in the diagnostic process.

show abstract

Section: Ancillary Investigationsmentioning

confidence: 99%

Section: Role Of Neuroimagingmentioning

confidence: 99%

Diagnostic Uncertainties in Tremor

2023

View full text Add to dashboard Cite

show abstract

“…Such a motor act is tremor defined as a rhythmic involuntary oscillatory movement of at least one functional area of the body. There are two main types of tremors: pathological and physiological [ 9 ]. Pathological tremor is caused by various disorders in the central or peripheral parts of the nervous system and can indicate diseases of the central nervous system [ 10 ], including cognitive disorders [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Strain Gauge Measuring System for Subsensory Micromotions Analysis as an Element of a Hybrid Human–Machine Interface

Bureneva

Safyannikov

2022

Sensors

View full text Add to dashboard Cite

The human central nervous system is the integrative basis for the functioning of the organism. The basis of such integration is provided by the fact that the same neurons are involved in various sets of sensory, cognitive, and motor functions. Therefore, the analysis of one set of integrative system components makes it possible to draw conclusions about the state and efficiency of the other components. Thus, to evaluate a person’s cognitive properties, we can assess their involuntary motor acts, i.e., a person’s subsensory reactions. To measure the parameters of involuntary motor acts, we have developed a strain gauge measuring system. This system provides measurement and estimation of the parameters of involuntary movements against the background of voluntary isometric efforts. The article presents the architecture of the system and shows the organization of the primary signal processing in analog form, in particular the separation of the signal taken from the strain-gauge sensor into frequency and smoothly varying components by averaging and subtracting the analog signals. This transfer to analog form simplifies the implementation of the digital part of the measuring system and allowed for minimizing the response time of the system while displaying the isometric forces in the visual feedback channel. The article describes the realization of the system elements and shows the results of its experimental research.

show abstract

“…As a result, new terms such as “ET plus” have been introduced to account for these intricate phenotypes. From this mélange of new information has ensued complex academic debates, but these have not necessarily filtered down to general neurologists, general practitioners and patients themselves [ 45 46 47 ].…”

Section: Introductionmentioning

confidence: 99%

Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Iglesias-Hernandez

Berry

Hernández

et al. 2022

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Brain donation is a challenging process, comprising four sequential stages: (1) the brain donation decision, (2) pre-mortem arrangements and follow up, (3) specimen collection and (4) tissue processing. It is important to understand the factors that are pertinent to each stage. Currently, there is extensive information on factors that involve donor's personal and cultural backgrounds and how these could affect the process. However, little is known about disease-specific factors that influence the process. The Essential Tremor Centralized Brain Repository was established in 2003, and after nearly 20 years of collecting essential tremor (ET) brain tissue, we are well-positioned to discuss the brain donation process from a disease-specific standpoint. In the current manuscript, we discuss ET disease-specific factors that influence the first two stages of the brain donation process. We center our discussion around three points: (1) factors that influence the patient's decision to donate, (2) the involvement of next of kin in the donation, and (3) the rationale for enrolling patients prospectively and evaluating them longitudinally before the anatomical gift takes place. This discussion shares our understanding of the background from which our repository operates and may be of value for other brain banks that study similar neurodegenerative diseases.

show abstract

The MDS consensus tremor classification: The best way to classify patients with tremor at present

Cited by 19 publications

References 43 publications

Diagnostic Uncertainties in Tremor

Diagnostic Uncertainties in Tremor

Strain Gauge Measuring System for Subsensory Micromotions Analysis as an Element of a Hybrid Human–Machine Interface

Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Contact Info

Product

Resources

About