The mean platelet volume in patients with obesity

Çoban, Erkan; Özdoğan, Mustafa; Yazicioglu, G.; Akçit, Ferhat

doi:10.1111/j.1742-1241.2005.00500.x

Cited by 256 publications

(193 citation statements)

References 13 publications

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“…BMI is a strong and independent risk factor for both venous and arterial thrombosis [3], and obese individuals are reported to have higher MPV than non-obese controls [22]. Even after adjustments for age, sex, smoking, BMI and platelet count in the multivariable model, MPV remained a risk factor for VTE in our study.…”

Section: Discussionmentioning

confidence: 47%

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Brækkan¹,

Mathiesen

Njølstad

et al. 2010

Journal of Thrombosis and Haemostasis

282

252

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Summary. Background: Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke. Objectives: The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous thromboembolism (VTE) in a prospective, population-based study. Methods: Platelet count, MPV and baseline characteristics were registered in 25 923 subjects aged 25-96 years who participated in the Tromsø Study in 1994-1995. Incident VTE events were registered to the end of followup (1 September 2007). Results: There were 445 validated incident VTE events (1.6 per 1000 person-years), of which 186 (42%) were unprovoked, during a mean of 10.8 years of followup. Subjects with MPV ‡ 9.5 fL had a 1.3-fold [95% confidence interval (CI) 1.0-1.7] higher risk of total VTE and a 1.5-fold (95% CI 1.1-2.3) higher risk of unprovoked VTE than subjects with MPV < 8.5 fL in analyses adjusted for age, sex, smoking, body mass index, and platelet count. Increasing MPV was associated with increased risk of total VTE (P for trend = 0.09) and unprovoked VTE (P for trend = 0.03) in analyses adjusted for age and sex. There was no significant association between increasing platelet count and risk of VTE. Conclusions: An increasing MPV was identified as a predictor for VTE, in particular VTE of unprovoked origin. The present findings support the concept that platelet reactivity is important in the pathogenesis of VTE.

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Section: Discussionmentioning

confidence: 47%

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Brækkan¹,

Mathiesen

Njølstad

et al. 2010

Journal of Thrombosis and Haemostasis

282

252

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“…Obese individuals have elevated MPV values. 23 Elevated MPV values have also been reported to correlate with a higher prevalence of metabolic syndrome. 24 In the present investigation, positive correlations were found between MPV and the prevalence of hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

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Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the followup period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles. The hazard ratios of hypertension for the II, III and IV (high) vs. I (low) quartiles of MPV were 1.13 (95% confidence interval (CI) 1.01-1.25, P = 0.027), 1.25 (95% CI 1.12-1.39, Po0.001) and 1.40 (95% CI 1.26-1.55, Po0.001), respectively. In multivariate Cox regression analysis, MPV predicted hypertension independently of age, sex, platelet count, waist circumference, drinking, systolic blood pressure and creatinine levels. The present study indicated that elevated MPV is associated with increased incidence of hypertension independent of other risk factors, which suggests that platelet activity may play a role in hypertension incidence.

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“…Mean platelet volume has been studied in many vascular diseases. Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes and increased MPV levels have been shown as an indicator in myocardial infarcts [4,[11][12][13], congestive heart disease [13], cerebrovascular diseases [14], obesity [15] and hypertensive patients [16,17]. There is a previous study that suggested a relationship between high MPV levels and an increase in the frequency of restenosis in patients who received coronary angioplasty [18].…”

Section: Discussionmentioning

confidence: 99%

Increased mean platelet volume in type 2 diabetes mellitus

Yenigun¹

2014

Diclemedj

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Diyabetik hastalarda vasküler komplikasyonların gelişiminde trombositler önemli rol oynamaktadır. Büyük trombositler küçüklere oranla daha aktif olup, ortalama trombosit hacmi (MPV) trombosit aktivitesini göstermede kullanılan bir belirteçdir. Biz bu çalışmamızda MPV'nin tip 2 diyabetes mellituslu hastalarda ve diyabetin mikrovasküler ve makrovasküler komplikasyonlardaki ilişkisi araştırmayı amaçladık. Yöntemler: Çalışmaya Dışkapı Eğitim ve Araştırma Hastanesi Dahiliye polikliniğinde takipli olan 48 tip 2 diyabetli ve 30 sağlıklı hasta dahil edilmiştir. Tüm hastalarda tam kan sayımı, açlık kan şekeri ve lipid parametreleri çalışıldı. Diyabetik hastalarda diyabet süresi, HbA1c düzeyi, mikrovasküler ve makrovasküler komplikasyon varlığı araştırıldı. Ortalama trombosit hacmi diyabetik ve sağlıklı kontrol grubu arasında ve diyabetik kolda komplikasyon olan olmayan grup arasında karşılaştırıldı. Bulgular: Diyabetik hastalarda MPV, non-diyabetik sağlıklılarla karşılaştırıldığında anlamlı yüksek saptandı. En az bir mikrovasküler komplikasyonu olan hastalarda olmayanlara göre MPV belirgin yüksek saptandı. Makrovasküler komplikasyonu olan hastalarda MPV olmayan hastalara göre yüksek bulundu. Sonuç: Hem diyabetiklerde hem de mikro-makrovasküler komplikasyonları olan diyabetik hastalarda MPV yüksek bulunmuştur.

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The mean platelet volume in patients with obesity

Cited by 256 publications

References 13 publications

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Association between mean platelet volume and hypertension incidence

Increased mean platelet volume in type 2 diabetes mellitus

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