The Means of Progress in Improving the Results of in vitro Fertilization Based on the Identification and Correction of the Pathology of Hemostasis

Момот, А. П.; Lydina, Inna; Цывкина, Л П; Borisova, Oksana; Serdyuk, G. V.

doi:10.5772/52898

Cited by 4 publications

(1 citation statement)

References 117 publications

(118 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently we have got evidence and experience in this field on the assessment of the effectivity of low molecular weight heparin usage in women with excessive thrombin generation in ovarian stimulation in in vitro fertilization cycle [102];…”

Section: Resultsmentioning

confidence: 99%

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

Моmot¹

2016

HBTD

View full text Add to dashboard Cite

Nowadays hematologists and obstetrician-gynecologists have little data about the peculiarities of hemostatic parameters and the maintenance of hemostatic balance at different stages of physiological pregnancy. However, it is necessary to know the norms for the determination of pathologic deviations in the system and medical decision making. The article presents the dynamics of 50 hemostatic parameters in women in pregravid period, at different stages of physiological pregnancy, and 2-3 days after vaginal delivery studied in 301 Caucasian (white) women. The parameters that characterize different components of hemostatic system were taken into account-vascular-platelet, coagulant, anticoagulant, and Fibrinolytic. Thrombin generation test was used as an integrated method to study hemocoagulation.According to the obtained results, some parameters were identified. These parameters could be an objective prerequisite for the prescription and monitoring the effects of antiaggregants and low molecular heparins during pregnancy with the aim of thromboprophylaxis. It is suggested that hyperproduction of Tissue Factor (TF) and thrombin (in relation to reference ranges) should play a possible role in initiation not only intravascular blood coagulation but also the end of pregnancy. It might be of importance in understanding the causes of preterm delivery. The described mechanism, preventing thrombus formation in late pregnancy, is associated with the enhancement of fibrinolytic reactions in blood circulation. This mechanism can lead to the degradation of soluble fibrin polymer (with the formation of D-dimers) before its conversion into gel or fibrin clot (fibrin insolubile). The obtained data could be useful in future to identify pregnant women at risk dealing with thrombosis, bleeding and obstetrics complications during pregnancy and delivery.Keywords: Blood coagulation markers; Coagulation factors; Fibrinolysis; Hemostatic system; Physiological anticoagulants; Pregnancy; Thrombin generation Citation: Моmot AP, Semenova NA, Belozerov DE, Trukhina DA, Kudinova IY (2016) interest since these data can be useful for the differential diagnostics of bleeding causes, as well as for the identification of patients needed in thromboprophylaxis.Moreover, simultaneous identification of a lot of parameters, characterizing coagulation, anticoagulant and fibrinolytic activity of blood could allow obtaining the important information about dynamically changing hemostatic balance during pregnancy, which is normally accompanied by neither bleedings nor thromboses. The study of these parameters is expected to explain the causes of 3-4 fold increase in D-dimers level in late physiological pregnancy, to select objective factors for initiation and cessation of heparinprophylaxis and to solve other problems associated with pregnancy complications.The aim of this study is to determine the allowed values and the dynamics of changes of a wide range of hemostatic parameters at different stages of physiological pregnancy and the first few day...

show abstract

Section: Resultsmentioning

confidence: 99%

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

Моmot¹

2016

HBTD

View full text Add to dashboard Cite

show abstract

Clinical effects of intermittent pneumatic compression

Момот¹,

Лебедева²,

Николаева³

et al. 2019

Probl. reprod.

View full text Add to dashboard Cite

The maternal factors of failures and defects of implantation after IVF

et al. 2020

View full text Add to dashboard Cite

Московский областной перинатальный центр; 143900, Россия, Московская область, Балашиха, шоссе Энтузиастов, д. 12 Резюме Введение. Неудачи и дефекты имплантации после ЭКО во многом определяются материнскими факторами, которые считаются достаточно управляемыми. Общая эффективность ЭКО, благодаря накоплению коллективного опыта и внедрению результатов передовых исследований в практику, неуклонно растет, но говорить о полной победе над инфертильностью пока слишком рано. До настоящего времени четко не определена врачебная тактика при выявлении наиболее значимых из них у пациенток, имеющих неудачи и дефекты имплантации в предыдущих программах ЭКО. Цель исследования. Обобщить данные литературы и результаты многолетних собственных исследований для определения врачебной тактики у пациенток с неудачами и дефектами имплантации в предыдущих программах ЭКО при выявлении значимых материнских факторов риска Материал и методы. Проведен анализ и обобщение данных 80 источников литературы с акцентом на работы отечественных авторов, включая публикации по результатам собственных исследований. Результаты. Выявлены наиболее значимые материнские факторы риска неудач и дефектов имплантации после ЭКО: хронический эндометрит и тромбофилии. Определен алгоритм прегравидарной подготовки у пациенток с хроническим эндометритом и с предыдущими неудачами и дефектами имплантации после ЭКО, включающий применение антибактериальной, противо вирусной, противовоспалительной, иммуномоделирующей и физиотерапии. Показана необходимость назначения низкомолекулярных гепаринов у пациенток с тромбофилией с момента установления беременности после ЭКО. Заключение. Проведение прегравидарной (предпрограммной) подготовки у пациенток с хроническим эндометритом и назначение низкомолекулярных гепаринов с ранних сроков беременности у пациенток с тромбофилией позволяет увеличить процент женщин, получивших беременность после ЭКО и преодолевших эмбрионический порог.

show abstract

The Means of Progress in Improving the Results of in vitro Fertilization Based on the Identification and Correction of the Pathology of Hemostasis

Cited by 4 publications

References 117 publications

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

The Dynamics of the Hemostatic Parameters in Physiological Pregnancy and After Delivery

Clinical effects of intermittent pneumatic compression

The maternal factors of failures and defects of implantation after IVF

Contact Info

Product

Resources

About