The mechanical properties of skin in vivo—a portable hand-held extensometer

Gunner, C. W.; Hutton, W. C.; Burlin, T. E.

doi:10.1111/j.1365-2133.1979.tb05555.x

Cited by 53 publications

(10 citation statements)

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“…In a finite element modelling context, it implies that using a single set of mechanical properties for the stratum corneum would limit the domain of validity of the simulation results to specific conditions. A wide array of experimental and clinical measurement techniques are used to characterise particular aspects of skin biology and biophysics (Alexiades-Armenakas, 2007;Batisse et al, 2002;Bellemere et al, 2009;Delalleau et al, 2006;Diridollou et al, 2000;Gunner et al, 1979;Hendriks et al, 2006;Jor et al, 2013;Limbert and Simms, 2013;Tonge et al, 2013a;Tonge et al, 2013b;Wan Abas, 1994). Nevertheless, complementary approaches based on mathematical and computational modelling techniques offer promising avenues to further our understanding of the skin (Areias et al, 2003;Bischoff et al, 2000;Boissieux et al, 2000;Buganza Tepole and Kuhl, 2014;Cavicchi et al, 2009;Duan et al, 2000;Evans, 2009;Flynn and McCormack, 2008a, b;Flynn andMcCormack, 2009, 2010;Hendriks et al, 2006;Hendriks et al, 2003;Kuwazuru et al, 2008;Larrabee and Galt, 1986a, b;Larrabee and Sutton, 1986;Lévêque and Audoly, 2013;Tepole et al, 2014a;Tepole et al, 2014b;Tepole et al, 2011;Zöllner et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.www.elsevier.com/locate/jmbbm 1 A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. AbstractThe study of skin biophysics has largely been driven by consumer goods, biomedical and cosmetic industries which aim to design products that efficiently interact with the skin and/or modify its biophysical properties for health or cosmetic benefits. The skin is a hierarchical biological structure featuring several layers with their own distinct geometry and mechanical properties. Up to now, no computational models of the skin have simultaneously accounted for these geometrical and material characteristics to study their complex biomechanical interactions under particular macroscopic deformation modes.The goal of this study was, therefore, to develop a robust methodology combining histological sections of human skin, image-processing and finite element techniques to address fundamental questions about skin mechanics and, more particularly, about how macroscopic strains are transmitted and modulated through the epidermis and dermis. The work hypothesis was that, as skin deforms under macroscopic loads, the stratum corneum does not experience significant strains but rather folds/unfolds during skin extension/compression.A sample of fresh human mid-back skin was processed for wax histology. Sections were stained and photographed by optical microscopy. The multiple images were stitched together to produce a larger region of interest and segmented to extract the geometry of the stratum corneum, viable epidermis and dermis. From the segmented structures a 2D finite element mesh of the skin composite model was created and geometrically non-linear plane-strain finite element analyses were conducted to study the sensitivity of the model to variations in mechanical properties.The hybrid experimental-computational methodology has offered valuable insights into the simulated mechanics of the skin, and that of the stratum corneum in particular, by providing qualitative and quantitative information on strain magnitude and distribution. Through a complex non-linear interplay, the geometry and mechanical characteristics of the skin layers (and their relative balance), play a critical role in conditioning the skin mechanical response to macroscopic in-plane compression and extension. Topographical features of the skin surface such as furrows were shown to act as an efficient means to deflec...

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Section: Introductionmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

109

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“…These 'extensometer-type' instruments have been the most popular among investigators using tensile testing devices [9,12,13]. The results are quite easily interpretable.…”

Section: Tensile Testingmentioning

confidence: 67%

EEMCO Guidance to the in vivo Assessment of Tensile Functional Properties of the Skin

Rodrigues

2001

Skin Pharmacol Physiol

113

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Tensile functions of the skin and subcutaneous tissues contribute to the appearance of the aged and photodamaged skin and to the effects of various other pathophysiological processes. The assessment of tensile functions of skin can be performed by distinct approaches mainly characterized by the orientation and magnitude of the imposed stress and strain over time. Testing methods are basically grouped into five major classes which include tensile, torsional, indentation, impact and elevation modes. Computed tensile variables are reproducible when the experimental procedure occurs under fully controlled conditions. Consistent and relevant information is yielded when the limitations and pitfalls typical for each test method are taken into consideration.

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“…The load forcing a surface against the skin is of course transmitted to the deeper tissues of the body. The effects and measurement of pressure on human tissues and the mechanical properties of skin have been extensively studied [Gunner et al, 1979;Leveque et al, 1980;Agache et al, 1980;Daly and Odland, 19791. Shear effects on skin, fat, and muscle cause severe problems in the use of artificial limbs and in the etiology of decubitus ulcers [Lewis and Nourse, 19791.…”

Section: Discussionmentioning

confidence: 99%

Measurements of friction injuries in man

Akers

1985

American J Industrial Med

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Repetitive frictional insults over years to human skin result in lichenification, callosites, and clavi (corns). No measurements of the forces involved have been made for callosites or corns. Two reports deal with lichenification produced by repeated rubbing over weeks. By contrast, friction blisters have been seriously studied because they can be produced in minutes and because foot blisters can disable soldiers. Three devices to measure the coefficient of friction of materials on man's skin and eight machines to rub man's skin are reviewed.

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The mechanical properties of skin in vivo—a portable hand-held extensometer

Cited by 53 publications

References 1 publication

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

EEMCO Guidance to the in vivo Assessment of Tensile Functional Properties of the Skin

Measurements of friction injuries in man

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