The Mediterranean diet and asthma

Koumpagioti, Despina; Boutopoulou, Barbara; Douros, Konstantinos

doi:10.1016/b978-0-12-818649-7.00029-1

Cited by 2 publications

(1 citation statement)

References 106 publications

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“…The higher consumption of UPF is inversely and significantly associated with the content of vitamin D in the diet [19]. Unlike other vitamins, in which its effect on asthma is explained by its antioxidant activity, the effect of vitamin D is determined by its ability to act as a modulator of the innate and adaptive immune responses [91]. Vitamin D affects the development of the lung and modulates numerous immunological pathways through the regulation of lymphocytes, antigen-presenting cells, and mast cells.…”

Section: Upfs As Major Drivers Of Poor Nutritional Diets the Role Of ...mentioning

confidence: 99%

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Frontela-Saseta,

Finlayson,

Sánchez-Moya

et al. 2024

Dietetics

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Obesity is considered an important risk factor for the onset of asthma, playing a key role in enhancing the disease’s severity. However, there is increasing evidence linking not only obesity but also overweight with a higher risk of asthma. Although the correlation between obesity and asthma has already been reported, several aspects are still not fully elucidated, mainly about the inflammatory processes underlying both diseases. It is well known that Western-type calorically rich diets and overfeeding can act as triggers of chronic metabolic inflammation, but few studies have examined associations between ultra-processed foods (UPFs) intake, despite its positive correlation with obesity, and biomarkers of inflammation. In addition to their nutrient composition, UPF may have chemical additives and contaminants from packaging, whose effects on health and food addiction are still under research. In this review, we provide an overview of the current data that identify the associations between the obese asthma phenotype and UPF consumption, highlighting the potential central role played by the intestinal microbiota.

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Section: Upfs As Major Drivers Of Poor Nutritional Diets the Role Of ...mentioning

confidence: 99%

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Frontela-Saseta,

Finlayson,

Sánchez-Moya

et al. 2024

Dietetics

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Re-Assessing the Role of Platelet Activating Factor and Its Inflammatory Signaling and Inhibitors in Cancer and Anti-Cancer Strategies

Tsoupras,

Adamantidi,

Finos

et al. 2024

Front. Biosci. (Landmark Ed)

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Since 2000s, we have outlined the multifaceted role of inflammation in several aspects of cancer, via specific inflammatory mediators, including the platelet activating factor (PAF) and PAF-receptor (PAFR) related signaling, which affect important inflammatory junctions and cellular interactions that are associated with tumor-related inflammatory manifestations. It is now well established that disease-related unresolved chronic inflammatory responses can promote carcinogenesis. At the same time, tumors themselves are able to promote their progression and metastasis, by triggering an inflammation-related vicious cycle, in which PAF and its signaling play crucial role(s), which usually conclude in tumor growth and angiogenesis. In parallel, new evidence suggests that PAF and its signaling also interact with several inflammation-related cancer treatments by inducing an antitumor immune response or, conversely, promoting tumor recurrence. Within this review article, the current knowledge and future perspectives of the implication of PAF and its signaling in all these important aspects of cancer are thoroughly re-assessed. The potential beneficial role of PAF-inhibitors and natural or synthetic modulators of PAF-metabolism against tumors, tumor progression and metastasis are evaluated. Emphasis is given to natural and synthetic molecules with dual anti-PAF and anti-cancer activities (Bio-DAPAC-tives), with proven evidence of their antitumor potency through clinical trials, as well as on metal-based anti-inflammatory mediators that constitute a new class of potent inhibitors. The way these compounds may promote anti-tumor effects and modulate the inflammatory cellular actions and immune responses is also discussed. Limitations and future perspectives on targeting of PAF, its metabolism and receptor, including PAF-related inflammatory signaling, as part(s) of anti-tumor strategies that involve inflammation and immune response(s) for an improved outcome, are also evaluated.

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The Mediterranean diet and asthma

Cited by 2 publications

References 106 publications

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Ultra-Processed Foods Consumption and Asthma in the Western Diet

Re-Assessing the Role of Platelet Activating Factor and Its Inflammatory Signaling and Inhibitors in Cancer and Anti-Cancer Strategies

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