The Merkel cell and associated neoplasms in the eyelids and periocular region

Kivelä, Tero; Tarkkanen, Ahti

doi:10.1016/0039-6257(90)90087-c

Cited by 115 publications

(87 citation statements)

References 116 publications

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“…Es más frecuente en población blanca y dos veces más frecuente en mujeres (3). La mitad de los MCC ocurren en la región de cabeza y cuello, y una décima parte en los párpados o región periocular con preferencia por el párpado superior (1,3).…”

Section: Discussionunclassified

Paciente joven con carcinoma de merkel palpebral: microcirugía de mohs versus exenteración

Rodríguez-Prieto

Alonso-Alonso

Toribio-García

et al. 2009

Arch Soc Esp Oftalmol

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RESUMENCaso clínico: Se presenta el caso de una paciente de 47 años afecta de progeria que después de tratamiento con ciclosporina por trasplante corneal presentó carcinoma de Merkel (MCC) palpebral. Tras exéresis completa mediante cirugía de Mohs (MMS) y tratamiento adyuvante con radioterapia, recidivó y fue necesario realizar exenteración orbitaria. La paciente se encuentra asintomática tras 24 meses de seguimiento. Discusión: El MCC es un tumor agresivo con mayor incidencia en ancianos, mujeres e inmunodeprimidos. Nuestra visión del enfermo debe ser global evitando añadir factores de riesgo a pacientes ya predispuestos. La MMS parece desaconsejada en el tratamiento del MCC, debiendo realizar una excisión radical si se produce recidiva.Palabras clave: Carcinoma de Merkel, microcirugía de Mohs, tumor palpebral, exenteración orbitaria, ciclosporina, paciente joven. ABSTRACT Case report:We present the case of a 47-year-old female suffering from progeria who developed an eyelid Merkel cell carcinoma (MCC) following cyclosporine treatment for a corneal transplant. She underwent excision of the lesion by Mohs micrographic surgery (MMS) and received adjuvant treatment with radiotherapy. Later she had a recurrent tumour for which a wide excision with orbital exenteration was performed. The patient was fit and well at the 24-month follow-up. Discussion: MCC is an aggressive tumour that has a larger incidence in elderly people, women and immunosuppressed patients. Our approach with the patient must be global, avoiding risk factors in predisposed subjects. MMS seems unsuitable for the treatment of MCC; if tumour recurrence occurs a wide resection should be performed (Arch Soc Esp Oftalmol 2009; 84: 581-584).

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Section: Discussionunclassified

Paciente joven con carcinoma de merkel palpebral: microcirugía de mohs versus exenteración

Rodríguez-Prieto

Alonso-Alonso

Toribio-García

et al. 2009

Arch Soc Esp Oftalmol

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“…12,21,23,33 Other markers of neuroendocrine differentiation that have been identified include CRG, 1 which is more specific than NSE. 12 CRG may occasionally be expressed in the absence of NSE, as was the situation in our first case. 32 NF positivity is variable, although a recently reported series found it to be positive in 100% of tumors studied.…”

Section: Discussionmentioning

confidence: 99%

“…12,23,33 Classically, the tumor is located in the dermis, spares the epidermis and is composed of relatively monotonous small blue cells with scant cytoplasm arranged in large, solid nests. Mitotic figures are usually abundant, and individual cell necrosis is common, as is lymphatic invasion.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphologic Features of Merkel Cell Carcinoma in Fine Needle Aspiration Biopsies

et al. 2000

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“…1,2,18 Merkel cell tumor at any skin site has rarely been reported in blacks. 7 A variety of adnexal tumors of the eyelid have been reported in series from referral centers and data reveal that most affected patients are white. 3,19,20 Incidence rates, however, cannot be determined from these studies.…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

“…Knowledge about uncommon malignant tumors of the eyelid is based principally on case series from tertiary care facilities, where referral bias may affect results and incidence rates cannot be determined because denominator populations are unknown. [3][4][5][6][7] We used the Florida Cancer Data System (FCDS) registry to study the types and distribution of malignant tumors of the eyelid other than basal cell and squamous cell carcinoma.…”

mentioning

confidence: 99%