The Mesenchymal Factors Regulating Epithelial Morphogenesis and Differentiation of the Chicken Stomach

Yasugi, Sadao; Fukuda, Kiyoshige

doi:10.2108/zsj.17.1

Cited by 25 publications

(16 citation statements)

References 18 publications

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“…It has long been shown that an induction by the mesenchyme is necessary for gland formation of PV epithelium (Haffen et al, 1987;Mizuno and Yasugi, 1990;Yasugi and Fukuda, 2000). Narita et al (Narita et al, 2000) have previously reported that Bmp2, which is specifically expressed in the PV mesenchyme, can induce gland formation.…”

Section: Possible Crosstalk Of Notch Signaling With Other Signaling Imentioning

confidence: 99%

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Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

et al. 2005

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Section: Possible Crosstalk Of Notch Signaling With Other Signaling Imentioning

confidence: 99%

“…It is well established that the epithelial-mesenchymal interaction is important for the development of the PV (Yasugi, 1984;Yasugi and Fukuda, 2000). Recently, several secreted molecules have been identified as signaling factors regulating the epithelial development of the PV.…”

Section: Introductionmentioning

confidence: 99%

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

et al. 2005

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“…It has now been well established that the differentiation of the proventricular epithelium requires signals from its mesenchyme (Yasugi & Fukuda 2000). Bone morphogenetic protein (BMP)‐2 (Narita et al .…”

Section: Introductionmentioning

confidence: 99%

Expression and function ofWnt5ain the development of the glandular stomach in the chicken embryo

Listyorini

Yasugi

2006

Dev Growth Differ

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The epithelium of the chicken embryonic glandular stomach (proventriculus) differentiates into both a glandular and a luminal epithelium, the cells of which express specific marker genes. The subsequent formation and differentiation of the glands then proceed under the influence of the mesenchyme. To search for possible candidates for the mesenchymal factors involved, we have now investigated the expression and function of Wnt5a in this process. Our current results show that Wnt5a is expressed in the mesenchyme during active gland formation and that overexpression of this gene in ovo results in the increased and ectopic expression of some of the marker genes of the luminal and glandular epithelia. In particular, the overexpression of Wnt5a markedly enhances the expression of the embryonic chicken pepsinogen gene, a marker of the glandular epithelium, indicating its role as a mesenchymal factor that regulates the differentiation of the proventricular epithelium.

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“…The importance of the mesenchyme in the development of the proventricular epithelium and gizzard epithelium was repeatedly shown by the experimental studies (Mizuno and Yasugi, 1990;Yasugi, 1994;Yasugi and Fukuda, 2000). For example, when the gizzard epithelium of 6 day embryo was recombined and cultivated with the proventricular mesenchyme of 6 day embryo, the epithelium formed gland structures and expressed ECPg, suggesting that the gizzard epithelium differentiated into the proventricular epithelium (Takiguchi et al, 1986;Hayashi et al, 1988b;Urase et al, 1996).…”

Section: Introductionmentioning

confidence: 90%

Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo

Hiramatsu¹,

Yasugi²

2004

Int. J. Dev. Biol.

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Determination of the developmental fate in the small intestinal epithelium of the chicken embryo has not been fully analyzed up to the present. This study was carried out to analyze the determination time of the developmental fate of the small intestinal epithelium under the influence of other mesenchymes. The small intestinal epithelium reassociated and cultivated with the proventricular or gizzard mesenchyme or the dermis expressed chicken intestinal fatty acid binding protein, sucrase and CdxA as occurs during the normal development of the small intestinal epithelium. The presumptive intestinal endoderm taken from an earlier stage embryo and associated and cultivated with the proventricular or gizzard mesenchyme, showed gene expression patterns which were the same as those found in normal development. However, when the dermis was associated, the epithelium expressed sonic hedgehog, but never expressed intestinal epithelial-or stomach epithelial-markers. These results indicate that the determination of the developmental fate in the small intestinal epithelium and acquisition of autodifferentiation potency occur at the early stage of the gut development. Moreover the presumptive intestinal endoderm needs the supportive influence of the gut mesenchyme in order to differentiate fully into the intestinal epithelium.

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The Mesenchymal Factors Regulating Epithelial Morphogenesis and Differentiation of the Chicken Stomach

Cited by 25 publications

References 18 publications

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

Expression and function ofWnt5ain the development of the glandular stomach in the chicken embryo

Molecular analysis of the determination of developmental fate in the small intestinal epithelium in the chicken embryo

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