The Metabaging Cycle

Ma, Suli; Shyh‐Chang, Ng

doi:10.1111/cpr.13197

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Metabolomic analysis of myofibers would improve our molecular understanding of all myofiber subtypes and their association with exercise performance, locomotion, sarcopenia ( 13 , 14 ), cachexia, muscle wasting, and muscle-associated metabolic diseases ( 15 , 16 ). Furthermore, under the influence of intrinsic and extrinsic factors, myofiber fates can be transformed from fast twitch to slow twitch or vice versa ( 17 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

Spatial metabolomics reveals skeletal myofiber subtypes

Luo

Liang

et al. 2023

Sci. Adv.

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Skeletal muscle myofibers are heterogeneous in their metabolism. However, metabolomic profiling of single myofibers has remained difficult. Mass spectrometry imaging (MSI) is a powerful tool for imaging molecular distributions . In this work, we optimized the workflow of matrix-assisted laser desorption/ionization (MALDI)–based MSI from cryosectioning to metabolomics data analysis to perform high–spatial resolution metabolomic profiling of slow- and fast-twitch myofibers. Combining the advantages of MSI and liquid chromatography–MS (LC-MS), we produced spatial metabolomics results that were more reliable. After the combination of high–spatial resolution MSI and LC-MS metabolomic analysis, we also discovered a new subtype of superfast type 2B myofibers that were enriched for fatty acid oxidative metabolism. Our technological workflow could serve as an engine for metabolomics discoveries, and our approach has the potential to provide critical insights into the metabolic heterogeneity and pathways that underlie fundamental biological processes and disease states.

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Section: Introductionmentioning

confidence: 99%

Spatial metabolomics reveals skeletal myofiber subtypes

Luo

Liang

et al. 2023

Sci. Adv.

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“…As a result, blood glucose is directed toward the synthesis of more fat in adipocytes, leading to the further elevation of free fatty acid concentrations and local hyperlipidemia. The increased blood glucose load contributes to systemic endogenous free radicals and inflammation, perpetuating the metabaging cycle [84].…”

Section: Fat Deposition Aggravates Lung Function Loss In Ipf Mechanis...mentioning

confidence: 99%

Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Cheng,

Jiang,

Pan

et al. 2023

Lipids Health Dis

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Idiopathic pulmonary fibrosis (IPF) is considered an age-related disease. Age-related changes, along with other factors such as obesity, hormonal imbalances, and various metabolic disorders, lead to ectopic fat deposition (EFD). This accumulation of fat outside of its normal storage sites is associated with detrimental effects such as lipotoxicity, oxidative stress, inflammation, and insulin resistance. This narrative review provides an overview of the connection between ectopic and visceral fat deposition in aging, obesity, and IPF. It also elucidates the mechanism by which ectopic fat deposition in the airways and lungs, pericardium, skeletal muscles, and pancreas contributes to lung injury and fibrosis in patients with IPF, directly or indirectly. Moreover, the review discusses the impact of EFD on the severity of the disease, quality of life, presence of comorbidities, and overall prognosis in IPF patients. The review provides detailed information on recent research regarding representative lipid-lowering drugs, hypoglycemic drugs, and lipid-targeting drugs in animal experiments and clinical studies. This may offer new therapeutic directions for patients with IPF.

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Sphingolipids mediate lipotoxicity in muscular dystrophies

Wang

Shyh‐Chang

2022

Life Medicine

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The Metabaging Cycle

Cited by 5 publications

References 29 publications

Spatial metabolomics reveals skeletal myofiber subtypes

Spatial metabolomics reveals skeletal myofiber subtypes

Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Sphingolipids mediate lipotoxicity in muscular dystrophies

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