2019
DOI: 10.1101/562058
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The Microbial Metagenome and Tissue Composition in Mice with Microbiome-Induced Reductions in Bone Strength

Abstract: The genetic components of microbial species that inhabit the body are known collectively as the microbiome. Modifications to the microbiome have been implicated in disease processes throughout the body and have recently been shown to influence bone. Prior work has associated changes in the microbial taxonomy (phyla, class, species, etc.) in the gut with bone phenotypes but has provided limited information regarding mechanisms. With the goal of achieving a more mechanistic understanding of the effects of the mi… Show more

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“…A trapezoidal loading function with 60 sec loading to 3000 µN, 30 sec holding at peak load, and 6 sec unloading was performed at each point. (42, 43) The fused quartz standard was tested before and after each mid-cortex grid to validate calibration and remove organic material from the tip. Force-displacement curves exhibiting nonlinearity during loading were removed from analysis.…”
Section: Methodsmentioning
confidence: 99%
“…A trapezoidal loading function with 60 sec loading to 3000 µN, 30 sec holding at peak load, and 6 sec unloading was performed at each point. (42, 43) The fused quartz standard was tested before and after each mid-cortex grid to validate calibration and remove organic material from the tip. Force-displacement curves exhibiting nonlinearity during loading were removed from analysis.…”
Section: Methodsmentioning
confidence: 99%