The Microbiome and Its Contribution to Skin Cancer

Coggshall, Kathleen; Brooks, Lionel; Nagarajan, Priyadharsini; Arron, Sarah T.

doi:10.1007/978-3-030-04155-7_5

Cited by 3 publications

(2 citation statements)

References 87 publications

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“…On the other hand, some chronic skin conditions may lead to alterations in the skin microbiome. Although no causative bacterial pathogen has been identified in melanomagenesis, alterations of the skin microbiome in chronic skin conditions may lead to colonization with pathogenic bacteria, which may in turn play a role in the development of non-melanoma skin cancers [13]. In addition, some small studies have shown differences in the skin microbiota in melanomas [14,15].…”

Section: Role Of Skin and Gut Microbiota In The Development Of Melano...mentioning

confidence: 99%

Microbial Influences on Immune Checkpoint Inhibitor Response in Melanoma: The Interplay between Skin and Gut Microbiota

Bouferraa,

Fares,

Bou Zerdan

et al. 2023

IJMS

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Immunotherapy has revolutionized the treatment of melanoma, but its limitations due to resistance and variable patient responses have become apparent. The microbiota, which refers to the complex ecosystem of microorganisms that inhabit the human body, has emerged as a promising area of research for its potential role in melanoma development and treatment response. Recent studies have highlighted the role of microbiota in influencing the immune system and its response to melanoma, as well as its influence on the development of immune-related adverse events associated with immunotherapy. In this article, we discuss the complex multifactorial mechanisms through which skin and gut microbiota can affect the development of melanoma including microbial metabolites, intra-tumor microbes, UV light, and the immune system. In addition, we will discuss the pre-clinical and clinical studies that have demonstrated the influence of different microbial profiles on response to immunotherapy. Additionally, we will explore the role of microbiota in the development of immune-mediated adverse events.

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Section: Role Of Skin and Gut Microbiota In The Development Of Melano...mentioning

confidence: 99%

Microbial Influences on Immune Checkpoint Inhibitor Response in Melanoma: The Interplay between Skin and Gut Microbiota

Bouferraa,

Fares,

Bou Zerdan

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…These microbes maintain the natural flora microbiota. 4 The human gastrointestinal tract is populated by a wide range of diverse communities of microbes.The natural flora gut microbiota maintains and plays a major role in various host functions and different diversity of the microbiota. 5 Human gut microbiota is the natural flora so even a small alternation or disturbance in this natural flora will lead to many infectious disease and gut interactions and many disorders.…”

Section: Introductionmentioning

confidence: 99%

A Current Review on Gut Microbiota For Healthy Life

2020

IJFMT

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The human gastrointestinal tract is highly populated by a vast and diverse community of different microbes. Every individual is provided with a unique gut microbiota which varies according to their food habits and dietary intakes. This human gastrointestinal tract gut microbiota has various functions by participating in host mechanisms or metabolisms acts as or gives protection against the pathogens invading microbes into the gut,and also play an important role in facilitating the immune system development and function. An slight alteration even in this natural flora of gut in the intestine can cause infectious disease and disorders to the human. Various infections due to antibiotics and gut bacterial communities,bacterial interactions,mood disorders,metabolic disorders,diabetes,allergic disease,inflammatory bowel disease,hormonal and many neurological processes can happen. Hence, it is very important in maintaining the natural flora of the gut as it maintains a healthy gut microbiota , structural integrity and protection. Recently ayurvedic medicines are used over allopathy for its less sides on the body and for maintaining a healthy gut microbiome. This review aims on the current status of the gut microbiota for healthy life under key problems identification and maintaining the current healthy gut microbiota in the human gastrointestinal tract.

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Dysbiosis of skin microbiome and gut microbiome in melanoma progression

et al. 2022

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Background The microbiome alterations are associated with cancer growth and may influence the immune system and response to therapy. Particularly, the gut microbiome has been recently shown to modulate response to melanoma immunotherapy. However, the role of the skin microbiome has not been well explored in the skin tumour microenvironment and the link between the gut microbiome and skin microbiome has not been investigated in melanoma progression. Therefore, the aim of the present study was to examine associations between dysbiosis in the skin and gut microbiome and the melanoma growth using MeLiM porcine model of melanoma progression and spontaneous regression. Results Parallel analysis of cutaneous microbiota and faecal microbiota of the same individuals was performed in 8 to 12 weeks old MeLiM piglets. The bacterial composition of samples was analysed by high throughput sequencing of the V4-V5 region of the 16S rRNA gene. A significant difference in microbiome diversity and richness between melanoma tissue and healthy skin and between the faecal microbiome of MeLiM piglets and control piglets were observed. Both Principal Coordinate Analysis and Non-metric multidimensional scaling revealed dissimilarities between different bacterial communities. Linear discriminant analysis effect size at the genus level determined different potential biomarkers in multiple bacterial communities. Lactobacillus, Clostridium sensu stricto 1 and Corynebacterium 1 were the most discriminately higher genera in the healthy skin microbiome, while Fusobacterium, Trueperella, Staphylococcus, Streptococcus and Bacteroides were discriminately abundant in melanoma tissue microbiome. Bacteroides, Fusobacterium and Escherichia-Shigella were associated with the faecal microbiota of MeLiM piglets. Potential functional pathways analysis based on the KEGG database indicated significant differences in the predicted profile metabolisms between the healthy skin microbiome and melanoma tissue microbiome. The faecal microbiome of MeLiM piglets was enriched by genes related to membrane transports pathways allowing for the increase of intestinal permeability and alteration of the intestinal mucosal barrier. Conclusion The associations between melanoma progression and dysbiosis in the skin microbiome as well as dysbiosis in the gut microbiome were identified. Results provide promising information for further studies on the local skin and gut microbiome involvement in melanoma progression and may support the development of new therapeutic approaches.

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The Microbiome and Its Contribution to Skin Cancer

Cited by 3 publications

References 87 publications

Microbial Influences on Immune Checkpoint Inhibitor Response in Melanoma: The Interplay between Skin and Gut Microbiota

Microbial Influences on Immune Checkpoint Inhibitor Response in Melanoma: The Interplay between Skin and Gut Microbiota

A Current Review on Gut Microbiota For Healthy Life

Dysbiosis of skin microbiome and gut microbiome in melanoma progression

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