The microbiome in a healthy pregnancy

Neuman, Hadar; Koren, Omry

doi:10.1016/b978-0-12-818097-6.00001-8

Cited by 4 publications

(3 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pregnancy leads to dramatic changes in the gut microbiome. In the last decades it has been demonstrated that during pregnancy a healthy microbiota undergoes a shift to a more dysbiotic one (68). In general, pregnancy reduces the alpha diversity and increases the beta diversity (69).…”

Section: Discussionmentioning

confidence: 99%

Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Sáez-Fuertes,

Kapravelou,

Grases-Pintó

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

IntroductionMaternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of B. breve M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition. MethodsLewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers.ResultsThe immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of Muc3, Cldn4, and Ocln. The higher production of short chain fatty acids in the cecum and increased Bifidobacterium counts suggest a potential positive impact on the gastrointestinal tract. DiscussionThese findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Sáez-Fuertes,

Kapravelou,

Grases-Pintó

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…An important side note is the observation that a healthy pregnancy leads to changes in the microbiota composition that resembles a dysbiotic composition – however, in the context of pregnancy with its unique needs and requirements, these adaptations are physiological ( 89 , 90 ). For example, Faecalibacterium , which is a SCFA producer, decreases in abundance in the last trimester of pregnancy.…”

Section: Gestational Imprinting Of the Neonatal Intestinal Innate Immune Systemmentioning

confidence: 99%

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

et al. 2021

View full text Add to dashboard Cite

The innate immune system is the oldest protection strategy that is conserved across all organisms. Although having an unspecific action, it is the first and fastest defense mechanism against pathogens. Development of predominantly the adaptive immune system takes place after birth. However, some key components of the innate immune system evolve during the prenatal period of life, which endows the newborn with the ability to mount an immune response against pathogenic invaders directly after birth. Undoubtedly, the crosstalk between maternal immune cells, antibodies, dietary antigens, and microbial metabolites originating from the maternal microbiota are the key players in preparing the neonate’s immunity to the outer world. Birth represents the biggest substantial environmental change in life, where the newborn leaves the protective amniotic sac and is exposed for the first time to a countless variety of microbes. Colonization of all body surfaces commences, including skin, lung, and gastrointestinal tract, leading to the establishment of the commensal microbiota and the maturation of the newborn immune system, and hence lifelong health. Pregnancy, birth, and the consumption of breast milk shape the immune development in coordination with maternal and newborn microbiota. Discrepancies in these fine-tuned microbiota interactions during each developmental stage can have long-term effects on disease susceptibility, such as metabolic syndrome, childhood asthma, or autoimmune type 1 diabetes. In this review, we will give an overview of the recent studies by discussing the multifaceted emergence of the newborn innate immune development in line with the importance of maternal and early life microbiota exposure and breast milk intake.

show abstract

Section: Discussionmentioning

confidence: 99%

DataSheet_1.pdf

View full text Add to dashboard Cite

The microbiome in a healthy pregnancy

Cited by 4 publications

References 101 publications

Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

DataSheet_1.pdf

Contact Info

Product

Resources

About