The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

Nguyen, John HV; Chung, Jin D.; Lynch, Gordon S.; Ryall, James G.

doi:10.3389/fcell.2019.00254

Cited by 40 publications

(29 citation statements)

References 124 publications

(144 reference statements)

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“…Skeletal muscle constitutes a significant percentage of total body mass and is indispensable to physical movements, maintaining postures and in vital actions (Diaz-Vegas et al, 2019;Hood et al, 2019). It is also a primary peripheral tissue important for utilizing glucose and fatty acid for energy generation essential for the prevention of obesity and type 2 diabetes (Dumont et al, 2015a;Nguyen et al, 2019). It is made up of thousands of long and cylindrical multinucleated muscle fibers surrounded by the sarcolemma, a lipid bi-layer membrane that attaches a complex extracellular matrix, which is in contact with the basement membrane (Dumont et al, 2015a).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Function in Muscle Stem Cell Fates

Bhattacharya

Scimè

2020

Front. Cell Dev. Biol.

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Mitochondria are crucial organelles that control cellular metabolism through an integrated mechanism of energy generation via oxidative phosphorylation. Apart from this canonical role, it is also integral for ROS production, fatty acid metabolism and epigenetic remodeling. Recently, a role for the mitochondria in effecting stem cell fate decisions has gained considerable interest. This is important for skeletal muscle, which exhibits a remarkable property for regeneration following injury, owing to satellite cells (SCs), the adult myogenic stem cells. Mitochondrial function is associated with maintaining and dictating SC fates, linked to metabolic programming during quiescence, activation, self-renewal, proliferation and differentiation. Notably, mitochondrial adaptation might take place to alter SC fates and function in the presence of different environmental cues. This review dissects the contribution of mitochondria to SC operational outcomes, focusing on how their content, function, dynamics and adaptability work to influence SC fate decisions.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Function in Muscle Stem Cell Fates

Bhattacharya

Scimè

2020

Front. Cell Dev. Biol.

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“…Nevertheless, previous clinical trials with MPCs showed variable cell numbers, different injection modes and the use of different substances, and possibly therefore led to variable outcomes. The next important point is the microenvironment for the non-muscle derived stem cells [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Muscle tissues that require contractile activity for proper functioning, could also be repaired or replaced by the means of TE, such as the various sphincters, bladder, intestine, diaphragm, face, hand, tongue, pharynx, larynx and oesophagus. In general, TE uses progenitor cells in combination with suitable biomaterials that together generate the appropriate microenvironment to functionally repair, replace and regenerate the damaged or lost organ [ 1 , 2 ]. However, production of engineered tissues and organs requires the use of large number of cells.…”

Section: Introductionmentioning

confidence: 99%

Adult stem cell sources for skeletal and smooth muscle tissue engineering

et al. 2022

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Introduction Tissue engineering is an innovative field with enormous developments in recent years. These advances are not only in the understanding of how stem cells can be isolated, cultured and manipulated but also in their potential for clinical applications. Thus, tissue engineering when applied to skeletal and smooth muscle cells is an area that bears high benefit for patients with muscular diseases or damage. Most of the recent research has been focused on use of adult stem cells. These cells have the ability to rejuvenate and repair damaged tissues and can be derived from different organs and tissue sources. Recently there are several different types of adult stem cells, which have the potential to function as a cell source for tissue engineering of skeletal and smooth muscles. However, to build neo‐tissues there are several challenges which have to be addressed, such as the selection of the most suitable stem cell type, isolation techniques, gaining control over its differentiation and proliferation process. Conclusion The usage of adult stem cells for muscle engineering applications is promising. Here, we summarize the status of research on the use of adult stem cells for cell transplantation in experimental animals and humans. In particular, the application of skeletal and smooth muscle engineering in pre-clinical and clinical trials will be discussed.

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“…One larger subpopulation would consist of SCs with a higher myogenic differentiation potential that readily undergo activation and proliferation after injury, while the other one would be mainly responsible for SC pool maintenance to ensure tissue regeneration in case of subsequent injuries. 154,155 In their quiescent state, satellite cells are specifically located between the basal lamina, which protects them from the surrounding milieu, and the sarcolemma of skeletal myofibers. 136 Muscle repair/regeneration upon damage is a tightly orchestrated process that begins with an inflammatory response followed by tissue necrosis, and then satellite cell activation, expansion, migration, differentiation, and fusion to restore injured myofibers or generate new myofibers.…”

Section: The Skeletal Muscle Sc Niche Microenvironment Before the Identification Of Tcsmentioning

confidence: 99%

Telocytes: An Emerging Component of Stem Cell Niche Microenvironment

Rosa

Marini

Manetti

2021

J Histochem Cytochem.

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Telocytes (TCs) are newly identified interstitial cells characterized by thin and long cytoplasmic processes, called telopodes, which exhibit a distinctive moniliform shape and, often, a sinuous trajectory. Telopodes typically organize in intricate networks within the stromal space of most organs, where they communicate with neighboring cells by means of specialized cell-to-cell junctions or shedding extracellular vesicles. Hence, TCs are generally regarded as supporting cells that help in the maintenance of local tissue homeostasis, with an ever-increasing number of studies trying to explore their functions both in physiological and pathological conditions. Notably, TCs appear to be part of stem cell (SC) niches in different organs, including the intestine, skeletal muscle, heart, lung, and skin. Indeed, growing evidence points toward a possible implication of TCs in the regulation of the activity of tissue-resident SCs and in shaping the SC niche microenvironment, thus contributing to tissue renewal and repair. Here, we review how the introduction of TCs into the scientific literature has deepened our knowledge of the stromal architecture focusing on the intestine and skeletal muscle, two organs in which the recently unveiled unique relationship between TCs and SCs is currently in the spotlight as potential target for tissue regenerative purposes.

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The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

Cited by 40 publications

References 124 publications

Mitochondrial Function in Muscle Stem Cell Fates

Mitochondrial Function in Muscle Stem Cell Fates

Adult stem cell sources for skeletal and smooth muscle tissue engineering

Telocytes: An Emerging Component of Stem Cell Niche Microenvironment

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