The microtubule cytoskeleton: A validated target for the development of 2-Aryl-1H-benzo[d]imidazole derivatives as potential anticancer agents

Park, Su Jeong; Song, In-ho; Yeom, Gyu Seong; Nimse, Satish Balasaheb

doi:10.1016/j.biopha.2023.116106

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2023.116106

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The microtubule cytoskeleton: A validated target for the development of 2-Aryl-1H-benzo[d]imidazole derivatives as potential anticancer agents

Su Jeong Park,

In-ho Song,

Gyu Seong Yeom

et al.

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Cited by 5 publications

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Benzimidazole‐Containing Compounds as Anticancer Agents

Acar Çevik,

Işik,

Kaya

et al. 2024

ChemistrySelect

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Cancer is the second leading cause of death today and remains a threat to human health. The advent of multi‐drug resistance and adverse effects make the current first‐line anti‐cancer medicines inadequate, despite the fact that numerous efforts have been made in the field of cancer therapy and significant progress has been made in the diagnosis and treatment of cancer. Consequently, the development of novel anticancer drugs with high activity and minimal toxicity is imperative. The benzimidazole ring has attracted the attention of medicinal chemists due to its medicinal and pharmacological properties. The heterocyclic pharmacophore of benzimidazole is a crucial scaffold for developing pharmaceuticals and drugs. In this review, we summarized the recent progress of benzimidazole as a privileged scaffold for the discovery of anti‐cancer agents based on biological targets, such as VEGFR (Vascular Endothelial Growth Factor), PI3 K inhibitors (Phosphoinositide 3‐kinase), EGFR kinase inhibitors (Epidermal Growth Factor Receptor), PARPs (Poly ADP‐ribose polymerases), Tubulin Polymerization, HAT/HDAC (histone acetylase/histone deacetylase), SphK1 (Sphingosine kinase‐1 inhibitors), aromatase, carbonic anhydrase, and topoisomerase inhibitors. The last 5 years of literature have been reviewed and relevant studies have been summarized in this review.

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Benzimidazole‐Containing Compounds as Anticancer Agents

Acar Çevik,

Işik,

Kaya

et al. 2024

ChemistrySelect

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Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation

Aljuhani,

Nafie,

Albujuq

et al. 2024

Bioorganic Chemistry

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Synthesis of novel imino-coumarin and acrylonitrile 2-benzazole hybrids as potent anticancer agents targeting tubulin

Pavlinac,

Persoons,

Beč

et al. 2025

Bioorganic Chemistry

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The microtubule cytoskeleton: A validated target for the development of 2-Aryl-1H-benzo[d]imidazole derivatives as potential anticancer agents

Cited by 5 publications

References 53 publications

Benzimidazole‐Containing Compounds as Anticancer Agents

Benzimidazole‐Containing Compounds as Anticancer Agents

Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation

Synthesis of novel imino-coumarin and acrylonitrile 2-benzazole hybrids as potent anticancer agents targeting tubulin

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