The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites

Elawa, Sherif; Mirdell, Robin; Tesselaar, Erik; Farnebo, Simon

doi:10.1016/j.mvr.2019.03.002

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…It should also be noted that the flowers of both forms of T. crocata as well as T. caliginosa have shown a high intensity of methyl nicotinate. The latter is a vasodilator, which is used in topical preparations as a rubefacient in case of muscle pain [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…We can see that the two forms of T. crocata have relatively different floral volatile profiles due to their higher intensities of sesquiterpenoids and phenylpropanoids, such as β-farnesene (23), farnesyl acetate (32), benzylacetate (37), and phenylethyl acetate (39), which have higher intensities in floral emanations of yellow crocata compared to orange crocata (Figure 3B). While compounds such as benzyl benzoate (48), eugenol (42), methyl eugenol (43), benzyl salicylate (50), and phenethyl benzoate (49) are more abundant in orange crocata flowers, T. caliginosa flowers are grouped on the right due to higher intensities of other compounds, such as 1-hexadecanol (61), hexadecyl ethanoate (66), methyl tetradecanoate (56), hexadecanal (59), and some phenylpropanoids, such as methyl benzoate (35) and methyl salicylate (38). Component 1: 31.22 % This is confirmed by the heatmap (Figure 4); indeed, it is shown that the 57 volatile compounds detected in the floral emissions of T. caliginosa and in the two forms of T. crocata, are grouped in four large groups in the dendogram of the heatmap.…”

Section: Chemometrics Analysis Of Volatile Organic Compoundsmentioning

confidence: 99%

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Extraction and Identification of Volatile Organic Compounds Emitted by Fragrant Flowers of Three Tillandsia Species by HS-SPME/GC-MS

Benfodda

Bénimèlis

et al. 2021

Metabolites

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Numerous volatile organic compounds (VOCs) with a large chemical diversity are emitted by plant flowers. They play an important role in the ecology of plants, such as pollination, defense, adaptation to their environment, and communication with other organisms. The Tillandsia genus belongs to the Bromeliaceae family, and most of them are epiphytes. The aromatic profile of the Tillandsia genus is scarcely described. In this study, we use the headspace solid phase microextraction (HS-SPME) coupled with gas chromatography combined with mass spectrometry (GC-MS) method developed in our laboratory to explore the chemical diversity of the VOCs of fragrant flowers of three species of the genus Tillandsia. We were able to identify, for the first time, 66 volatile compounds (monoterpenes, sesquiterpenes, phenylpropanoids, and other compounds). We identified 30 compounds in T. xiphioides, 47 compounds in T. crocata, and 43 compounds in T. caliginosa. Only seven compounds are present in all the species studied. Comparison of the volatile compounds profiles by principal component analysis (PCA) between T. xiphoides, T. crocata, and T. caliginosa species showed a clear difference in the floral emissions of the studied species. Moreover, floral VOCs profiles allowed to differentiate two forms of T. xiphioides and of T. crocata.

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Section: Discussionmentioning

confidence: 99%

Section: Chemometrics Analysis Of Volatile Organic Compoundsmentioning

confidence: 99%

Extraction and Identification of Volatile Organic Compounds Emitted by Fragrant Flowers of Three Tillandsia Species by HS-SPME/GC-MS

Benfodda

Bénimèlis

et al. 2021

Metabolites

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“…This means that the conclusions in these studies are mostly based on wounds from these anatomical regions. There is a known variation in baseline perfusion in different areas of the body and perfusion response after provocations also seem to vary [76]. The results presented in this thesis should therefore be used with care for areas such as palms, soles, and face since optimal cut-offs might be slightly different.…”

Section: Study Related Limitationsmentioning

confidence: 97%

Blood Flow Dynamics in Burns

Mirdell

2019

Linköping University Medical Dissertations

Self Cite

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Burns of intermediate thickness are hard to evaluate clinically. This often leads to unnecessary delays of up to 14 days before a surgical decision can be made. To counter this, several objective methods have been developed to determine the healing potential of the wound. Over the years, measurement of perfusion has proven to be the most successful method for evaluation of healing potential. Laser Doppler imaging (LDI) is currently the most used method and can determine surgical need 2 days after injury with an accuracy >90%. There are however emerging techniques like laser speckle contrast imaging (LSCI), which also measure perfusion. LSCI have several advantages over LDI and is easier to use. LSCI can also investigate aspects of the microcirculation, previously not possible with LDI. The aim of this thesis was to investigate LSCI's ability to evaluate surgical need in burns of indeterminate partial-thickness. The first objective was to investigate the dynamics of perfusion the first 14 days after injury. The purpose was to find the optimal time-window for perfusion measurements. The next goal was to determine the accuracy of different perfusion cutoffs. In this second study, the benefit of a subsequent measurement was also investigated. After this, interobserver variation between different profession groups was studied. Both the agreement of perfusion measurements and observer assessments were evaluated. Finally, cardiac vasomotion in combination with perfusion (pulsatility) was investigated as a method to determine surgical need <48 hours after injury. Methods:

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“…The increasing vasodilatory effect of MN will plateau and reach its maximum within approximately 5 to 10 minutes. 81,82 (fig. 17)…”

Section: Methyl Nicotinatementioning

confidence: 99%

Laser Speckle Contrast Imaging in Reconstructive Surgery

Zötterman

2020

Linköping University Medical Dissertations

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The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites

Cited by 11 publications

References 13 publications

Extraction and Identification of Volatile Organic Compounds Emitted by Fragrant Flowers of Three Tillandsia Species by HS-SPME/GC-MS

Extraction and Identification of Volatile Organic Compounds Emitted by Fragrant Flowers of Three Tillandsia Species by HS-SPME/GC-MS

Blood Flow Dynamics in Burns

Laser Speckle Contrast Imaging in Reconstructive Surgery

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