The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles

Soni, Jay Prakash; Chemitikanti, Krishna Sowjanya; Joshi, Swanand Vinayak; Shankaraiah, Nagula

doi:10.1039/d0ob01779e

Cited by 22 publications

(6 citation statements)

References 147 publications

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“…[44] There are several books, journal reviews, and monographs dedicated to MW-assisted synthesis [45][46][47][48][49][50] giving in-depth coverage of the subject matter. There have recently been a few reviews published in the literature on the use of microwaves in the synthesis of N-heterocyclic compounds; [51][52][53][54][55] however, there is a lack of publications on the use of microwaves in the synthesis of fluorinated 5-membered N-heterocycles. This article highlights the microwave-assisted fluorination of 5-membered N-heterocyclic compounds along with the synthesis of fluorinated 5-membered N-heterocyclic compounds using fluorinated starting materials.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

Prakash,

Singh

2024

ChemistrySelect

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The fluorinated 5‐membered N‐containing heterocyclic compounds have wide utility in varied fields. The importance of these compounds has encouraged researchers to explore environment‐friendly synthetic techniques for their synthesis. In this context, microwave‐assisted synthesis has proved beneficial for the synthesis of fluorinated 5‐membered N‐heterocycles in an environmentally benign and energy‐efficient manner. Compared to conventional heating, it offers several advantages, including quick heating, short reaction times, higher yields, and fewer side reactions. This article highlights the microwave‐assisted fluorination of 5‐membered N‐heterocyclic compounds along with the synthesis of fluorinated 5‐membered N‐heterocyclic compounds using fluorinated starting materials.

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Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

Prakash,

Singh

2024

ChemistrySelect

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“…Recently, Dolzhenko centered a book chapter around named MCR assisted by microwave irradiations [34]. Similarly, in the recent past our research group [35] focussed on unveiling microwave reactions for non-fused single nitrogencontaining heterocycles. A mechanistic understanding of a reaction progression promotes better conceptualization of strategies effectively.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects

Gulati¹,

John²,

Shankaraiah³

2021

Beilstein J. Org. Chem.

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Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged as one of the useful tools in the synthesis of biologically relevant heterocycles. These reactions are strategically employed for the generation of a variety of heterocycles along with multiple point diversifications. Over the last few decades classical MCRs such as Ugi, Biginelli, etc. have witnessed enhanced yield and efficiency with microwave assistance. The highlights of MWA-MCRs are high yields, reduced reaction time, selectivity, atom economy and simpler purification techniques, such an approach can accelerate the drug discovery process. The present review focuses on the recent advances in MWA-MCRs and their mechanistic insights over the past decade and shed light on its advantage over the conventional approach.

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“…Very recently, we have reviewed microwave‐assisted chemistry of non‐(benzo) fused single nitrogen‐containing N ‐heterocycles [6n] . However, there is a scope to update the latest reports of microwave‐assisted fascinating chemistry of poly‐ aza ‐heterocycles from the past decade.…”

Section: Introductionmentioning

confidence: 99%

The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

et al. 2021

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The application of microwave technique in chemical laboratory rooted back in 1986 and found advantageous over conventional approaches. On the other side, poly‐aza‐heterocycles are influencing organic frameworks with a fascinating chemistry and well explored by employing microwave‐assisted organic reactions. In the present review, we have thoroughly updated rousing literatures of microwave‐assisted synthesis and reactions of various poly‐aza‐heterocycles viz., triazole, tetrazole, triazine, and tetrazine from the past decade (2010–2020). The expedient chemistry and enabling role of microwave heating for adequate chemical transformations of such heterocycles, which were more challenging using classical approaches, are appropriately elucidated. This review also highlights the potential applications of these heterocyclic scaffolds and their derivatives in different scientific domains. Remarkably, such chemical architects possess wide applications as crucial building blocks in synthesis of biologically relevant compounds, agrochemicals, and compounds of interest in material science.

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The microwave-assisted syntheses and applications of non-fused single-nitrogen-containing heterocycles

Abstract: Microwave technology has emerged as a great tool for the efficient synthesis of organic compounds and provides opportunities for the chemists to achieve adequate chemical transformations, which were amenable to...

Cited by 22 publications

References 147 publications

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects

The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

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