The Mitigating Effect of Jatropha curcas L. Latex against Genotoxicity Induced by Doxorubicin

Bailão, Elisa Flávia Luiz Cardoso; Pereira, Illana Reis; Silva, Jeniffer Gabrielle Vieira; Sousa, Maria Alice Montes de; Matos, Fábio Santos; Borges, Leonardo Luiz; Gonçalves, Pablo José; Reis, Paulo Roberto de Melo; Almeida, Luciane Madureira

doi:10.9734/ejmp/2019/v30i130166

Cited by 3 publications

(2 citation statements)

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“…Studies using mouse bone marrow erythrocytes supported previous findings, which indicated that J.curcas latex can induce cytotoxic and mutagenic potential in mammalian cells ( Bailão et al., 2019 ). Surprisingly, co-administration of the latex along with doxorubicin, a common chemotherapy drug, reduced the normally-observed induced side effects.…”

Section: Anticancer Properties Of Latex-bearing Plant Extractssupporting

confidence: 82%

“…This is presumably due to J. curcas latex showing protective activity towards cells through scavenging free radicals. It is worth noting that since herb-drug interactions are not well inspected, such treatment can result in reduction of drug activity ( Bailão et al., 2019 ). To gain more data on the safety of J. curcas latex use, cytotoxicity of 37-10.000 μg/ml latex was evaluated by the MTT assay.…”

Section: Anticancer Properties Of Latex-bearing Plant Extractsmentioning

confidence: 99%

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Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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Section: Anticancer Properties Of Latex-bearing Plant Extractssupporting

confidence: 82%

Section: Anticancer Properties Of Latex-bearing Plant Extractsmentioning

confidence: 99%