The modulatory effect of lipids and glucose on the neonatal immune response induced by Staphylococcus epidermidis

Haase, Berit; Faust, Kirstin; Heidemann, Mathias; Scholz, Tasja; Demmert, Martin; Tröger, Birte; Herz, Alexander; Härtel, Christoph

doi:10.1007/s00011-010-0258-5

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Intracytoplasmic IL-6 production was demonstrated to be nearly 4 times higher at a multiplicity of infection value of 10:1 (colony forming unit: white blood cell) than at 1:1 [ 81 ]. Furthermore, S. epidermidis strains positive for icaADBC seem to induce a higher level of IL-8 while inhibiting the release of IL-6 as compared to icaADBC negative strains [ 81 , 83 ]. This may be associated with the pathogenicity of clinically invasive S. epidermidis clones.…”

Section: S Epidermidis -Driven Cytokine and Chemomentioning

confidence: 99%

“…Furthermore, most in vitro studies used heat-killed S. epidermidis , which has been demonstrated to mount a different pattern of cytokine production compared to live bacteria [ 85 ]. Other confounding factors may include TLR2 gene polymorphism [ 84 ], S. epidermidis strain phenotypes [ 83 ], and experimental methods.…”

Section: S Epidermidis -Driven Cytokine and Chemomentioning

confidence: 99%

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Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity

Dong

Speer²,

Glaser³

2018

Virulence

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Staphylococcus epidermidis accounts for the majority of cases of neonatal sepsis. Moreover, it has been demonstrated to be associated with neonatal morbidities, such as bronchopulmonary dysplasia (BPD), white matter injury (WMI), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP), which affect short-term and long-term neonatal outcome. Imbalanced inflammation has been considered to be a major underlying mechanism of each entity. Conventionally regarded as a harmless commensal on human skin, S. epidermidis has received less attention than its more virulent relative Staphylococcus aureus. Particularities of neonatal innate immunity and nosocomial environmental factors, however, may contribute to the emergence of S. epidermidis as a significant nosocomial pathogen. Neonatal host response to S. epidermidis sepsis has not been fully elucidated. Evidence is emerging regarding the implication of S. epidermidis sepsis in the pathogenesis of neonatal inflammatory diseases. This review focuses on the interplay among S. epidermidis, neonatal innate immunity and inflammation-driven organ injury.

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Section: S Epidermidis -Driven Cytokine and Chemomentioning

confidence: 99%

Section: S Epidermidis -Driven Cytokine and Chemomentioning

confidence: 99%

Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity

Dong

Speer²,

Glaser³

2018

Virulence

View full text Add to dashboard Cite

show abstract

“…The reason for enhanced growth in the context of lipid administration is not clear. A modulation of the proinflammatory cytokine response to Staphylococcus epidermidis by lipids has been suggested [30]. In a S. epidermidis sepsis model of whole cord blood cells from healthy infants, IL-6, IL-8, and TNF-α expression of CD14+ cells was signiﬁcantly enhanced upon addition of a 1% lipid formulation, while lower lipid concentrations had no remarkable effect.…”

Section: Growth Of Microorganisms In Parenteral Nutritionmentioning

confidence: 99%

Risk of Parenteral Nutrition in Neonates—An Overview

2012

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Healthcare-associated infections (HAI) in preterm infants are a challenge to the care of these fragile patients. HAI-incidence rates range from 6 to 27 infections per 1000 patient-days. Most nosocomial infections are bloodstream infections and of these, the majority is associated with the use of central venous catheters. Many studies identified parenteral nutrition as an independent risk factor for HAI, catheter-associated bloodstream infection, and clinical sepsis. This fact and various published outbreaks due to contaminated parenteral nutrition preparations highlight the importance of appropriate standards in the preparation and handling of intravenous solutions and parenteral nutrition. Ready-to-use parenteral nutrition formulations may provide additional safety in this context. However, there is concern that such formulations may result in overfeeding and necrotizing enterocolitis. Given the risk for catheter-associated infection, handling with parenteral nutrition should be minimized and the duration shortened. Further research is required about this topic.

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Cord Blood Stem Cells for Clinical Use

Zhao

2015

Cord Blood Stem Cells and Regenerative Medicine

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The modulatory effect of lipids and glucose on the neonatal immune response induced by Staphylococcus epidermidis

Cited by 6 publications

References 33 publications

Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity

Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity

Risk of Parenteral Nutrition in Neonates—An Overview

Cord Blood Stem Cells for Clinical Use

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