The molecular mechanism of stipe cell wall extension for mushroom stipe elongation growth

Liu, Cuicui; Bi, Jing; Kang, Liqin; Zhou, Jinhua; Liu, Xiao; Z, Liu; Yuan, Sheng

doi:10.1016/j.fbr.2020.11.001

Cited by 25 publications

(43 citation statements)

References 98 publications

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“…chitin-and glucan-active glycoside hydrolases, expansins, CE4 chitooligosaccharide deacetylases, laccases) previously linked to fruiting body morphogenesis (Pezzella et al, 2013;Xie et al, 2018) were shared between C. neoformans and CM species (Table S8), suggesting that these families are important for sexual morphogenesis in general, not restricted to CM. Cell wall remodeling enzymes have been hypothesised to produce fruiting body-specific cell wall architectures (Buser et al, 2010;Krizsán et al, 2019;Liu et al, 2021;Ohga, 2000); the upregulation of these in C. neoformans suggests a role during non-CM sexual processes as well, possibly in generating aerial hypha-or basidiumspecific cell walls. Most genes related to glycogen metabolism also showed shared expression (Table S8).…”

Section: Sexual and CM Development Recruit Genes Of Different Agesmentioning

confidence: 99%

“…Accordingly, while some hitherto identified genes can be linked to CM functions (e.g. defense of fruiting bodies Künzler, 2018), most fruiting body-expressed genes, including those related to cell wall remodeling (Liu et al, 2021), transcriptional regulation, selective protein degradation (Krizsán et al, 2019), complex secretomes (Almási et al, 2019) may relate either to CM or more general functions.…”

Section: Introductionmentioning

confidence: 99%

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Gene age predicts the transcriptional landscape of sexual morphogenesis in multicellular fungi

Merényi

Virágh

Gluck‐Thaler

et al. 2021

Preprint

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Multicellularity has been one of the most important innovations in the history of life. The role of regulatory evolution in driving transitions to multicellularity is being increasingly recognized; however, patterns and drivers of transcriptome evolution are poorly known in many clades. We here reveal that allele-specific expression, natural antisense transcripts and developmental gene expression, but not RNA editing or a developmental hourglass act in concert to shape the transcriptome of complex multicellular fruiting bodies of fungi. We find that transcriptional patterns of genes are strongly predicted by their evolutionary age. Young genes showed more expression variation both in time and space, possibly because of weaker evolutionary constraint, calling for partially non-adaptive interpretations of evolutionary changes in the transcriptome of multicellular fungi. Gene age also correlated with function, allowing us to separate fruiting body gene expression related to simple sexual development from that potentially underlying complex morphogenesis. Our study highlighted a transcriptional complexity that provides multiple speeds for transcriptome evolution, but also that constraints associated with gene age shape transcriptomic patterns during transitions to complex multicellularity in fungi.

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Section: Sexual and CM Development Recruit Genes Of Different Agesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gene age predicts the transcriptional landscape of sexual morphogenesis in multicellular fungi

Merényi

Virágh

Gluck‐Thaler

et al. 2021

Preprint

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“…(Buser et al 2010a;Almási et al 2019;Krizsán et al 2019;Zhou et al 2019)), although most of that is based on transcriptome rather than functional studies. For example, stipe growth may be realized by the breaking of chitin-glucan cross-links by hydrolytic enzymes (Liu et al 2021). Similarly, there are cross-linking (transglycosidases) and lytic (e.g.…”

Section: Cell Wall Biosynthesis and Modificationmentioning

confidence: 99%

“…Recent studies suggested that expansin-like proteins are involved in stipe cell elongation in F. velutipes (Q et al 2018) andC. cinerea(Niu et al 2015) and were shown to have a role in stipe elongation, by loosening the chitin polymer structure (reviewed by (Liu et al 2021)).…”

Section: Expansins and Cerato-plataninsmentioning

confidence: 99%

“…Cell expansion also probably follows different mechanisms in each tissue. For example, according to the model of stipe elongation in C. cinerea proposed by Liu et al (Liu et al 2021), CE4 and GH30 genes may contribute to the rigidification of the cell wall in the stipe base, causing it to be more resistant to loosening by lytic enzymes than the stipe apex, thereby reducing its elongation potential. It is reasonable to assume that similar mechanisms underlie the differential expansion potential of different tissues within the fruiting body.…”

Section: Transition To Growth By Expansionmentioning

confidence: 99%

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Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Nagy

Vonk

Künzler

et al. 2021

Preprint

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Fruiting bodies of mushroom-forming fungi (Agaricomycetes) are among the most complex structures produced by fungi. Unlike vegetative hyphae, fruiting bodies grow determinately and follow a genetically encoded developmental program that orchestrates tissue differentiation, growth and sexual sporulation. In spite of more than a century of research, our understanding of the molecular details of fruiting body morphogenesis is limited and a general synthesis on the genetics of this complex process is lacking. In this paper, we aim to comprehensively identify conserved genes related to fruiting body morphogenesis and distill novel functional hypotheses for functionally poorly characterized genes. As a result of this analysis, we report 921 conserved developmentally expressed gene families, only a few dozens of which have previously been reported in fruiting body development. Based on literature data, conserved expression patterns and functional annotations, we provide informed hypotheses on the potential role of these gene families in fruiting body development, yielding the most complete description of molecular processes in fruiting body morphogenesis to date. We discuss genes related to the initiation of fruiting, differentiation, growth, cell surface and cell wall, defense, transcriptional regulation as well as signal transduction. Based on these data we derive a general model of fruiting body development, which includes an early, proliferative phase that is mostly concerned with laying out the mushroom body plan (via cell division and differentiation), and a second phase of growth via cell expansion as well as meiotic events and sporulation. Altogether, our discussions cover 1480 genes of Coprinopsis cinerea, and their orthologs in Agaricus bisporus, Cyclocybe aegerita, Armillaria ostoyae, Auriculariopsis ampla, Laccaria bicolor, Lentinula edodes, Lentinus tigrinus, Mycena kentingensis, Phanerochaete chrysosporium, Pleurotus ostreatus, and Schizophyllum commune, providing functional hypotheses for ~10% of genes in the genomes of these species. Although experimental evidence for the role of these genes will need to be established in the future, our data provide a roadmap for guiding functional analyses of fruiting related genes in the Agaricomycetes. We anticipate that the gene compendium presented here, combined with developments in functional genomics approaches will contribute to uncovering the genetic bases of one of the most spectacular multicellular developmental processes in fungi. Key words: functional annotation; comparative genomics; cell wall remodeling; development; fruiting body morphogenesis; mushroom; transcriptome

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Navigating the labyrinth – Searching for mechanistic clues to explain the evolution of sequestrate Agaricales with labyrinthine internal chambers

Nilsen,

Plett,

May

et al. 2024

Fungal Biology Reviews

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The molecular mechanism of stipe cell wall extension for mushroom stipe elongation growth

Cited by 25 publications

References 98 publications

Gene age predicts the transcriptional landscape of sexual morphogenesis in multicellular fungi

Gene age predicts the transcriptional landscape of sexual morphogenesis in multicellular fungi

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Navigating the labyrinth – Searching for mechanistic clues to explain the evolution of sequestrate Agaricales with labyrinthine internal chambers

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