1997
DOI: 10.1159/000203686
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The Monosomy 7 Clone in Interphase and Metaphase Cell Populations: A Combined Chromosome and Primed in situ Labeling Study

Abstract: Loss of a chromosome 7 is associated with a poor prognosis in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Some studies have shown higher frequencies of monosomy 7 (-7) in dividing than nondividing myeloid cells, which might indicate that -7 confers a proliferative advantage on the host cell. As other groups have not been able to confirm this, we compared the -7 frequencies in bone marrow metaphases as studied with conventional cytogenetics and in interphase cells using primed in situ (PRI… Show more

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Cited by 6 publications
(4 citation statements)
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“…It is probable that the deleted chromosomal bands involve the location for the unidentified myeloid specific tumor suppressor loci (Boultwood and Fidler 1995). Loss of a chromosome 7 is also associated with a poor prognosis in acute myeloid leukemia (Kadam et al 1993, Fischer et al 1996, Pedersen et al 1997.…”
Section: Discussionmentioning
confidence: 99%
“…It is probable that the deleted chromosomal bands involve the location for the unidentified myeloid specific tumor suppressor loci (Boultwood and Fidler 1995). Loss of a chromosome 7 is also associated with a poor prognosis in acute myeloid leukemia (Kadam et al 1993, Fischer et al 1996, Pedersen et al 1997.…”
Section: Discussionmentioning
confidence: 99%
“…Among them, 3 patients developed MDS after chemotherapy for multiple myeloma (Smadja et al,1988;Iurlo et al, 1989) or chronic lymphocytic leukemia (Wang et al, 1997). Acute myeloid leukemia in 9 (4M/5F aged 13 to 79 years, median 67 years): 1 acute myeloblastic leukemia with maturation (AML-M2) (Poppe et al, 2004), 2 acute myelomonocytic leukemia (AML-M4) (Adriaansen et al, 1988;Poppe et al, 2004), 1 acute monoblastic leukemia without differentiation (AML-M5a) (Negrini et al, 1995), 1 acute megakaryoblastic leukemia (AML-M7) (Teyssier et al, 1987) and 4 acute myeloid leukemia, NOS (Pedersen et al, 1997;Van Limbergen et al, 2002;Shali et al, 2006;Moosavi et al, 2009). 1 of them developed acute myeloid leukemia 1 year after a myeloproliferative disorder was diagnosed (Negrini et al, 1995).…”
Section: Etiologymentioning
confidence: 99%
“…Present as a supernumerary +i(9)(p10), in addition to two normal chromosomal 9 in 23 patients: 1 MPD (Hoo et al, 1987), 3 PV (Chen et al, 1998;Najfeld et al, 2007), 5 MDS (Billstrom et al, 1988Smadja et al, 1988;Lindvall et al, 2001;Stamatoullas et al, 2006;Najfeld et al, 2007), 3 AML (Teyssier et al, 1987Pedersen et al 1997;Van Limbergen et al, 2002), 1 ALL (Coyaud et al, 2010) and 10 B-cell lymphomas (Tilly et al, 1991;Dohner et al, 1992;Mikraki et al, 1992;Schlegelberger et al, 1994;Cook et al, 2004;Ruminy et al, 2006;Chapiro et al, 2008;Bacher et al, 2011;Narayan et al, 2013;Van Roosbroeck et al, 2016).…”
Section: Cytogenetics Morphologicalmentioning
confidence: 99%
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