The morbid anatomy and histology of anaphylaxis in the dog

Dean, H. R.; Webb, Robyn

doi:10.1002/path.1700270106

Cited by 36 publications

(7 citation statements)

References 3 publications

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“…8,11,13 In dogs, the main shock organ is the liver leading to GI signs such as vomiting and diarrhoea (over 90%). [14][15][16][17][18] Some GI changes may be due to direct histamine release from the intestine, but are mostly associated with mediator release directly from the liver, as shown in a study with dehepatized dogs. 15,19 The cardiovascular signs are most often secondary to liver changes (hepatic arterial vasodilation and increase in hepatic portal vascular resistance).…”

Section: Introductionmentioning

confidence: 99%

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Rostaher¹,

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2017

Advances in Veterinary Dermatology

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Background -Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions.Hypothesis/Objectives -This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria.Animals -Twenty four dogs with signs of urticaria with or without anaphylaxis.Methods -The study included dogs with cutaneous immediate-type hypersensitivity reactions. The cases were grouped by clinical severity into either an urticaria or an anaphylaxis group. All treatments and diagnostic tests (haematology, biochemical profile, allergy investigation) were recorded. A causality algorithm for urticaria and anaphylaxis (ALUA) was designed to determine the probability of the identified triggers and cofactors. Disease incidence, breed, age and gender predispositions were evaluated statistically.Results -Sixteen of 24 urticaria cases were associated with anaphylaxis whilst 8 of 24 were confined to the skin. The annual hospital incidence was 0.12%. Females seemed to be over-represented (2.4:1) and most of the dog breeds were pure breed (22 of 24), with Rhodesian ridgeback, boxer, beagle, Jack Russell terrier, French bulldog and Vizslas over-represented. In addition to skin lesions, the most frequently and severely affected organ systems were the gastrointestinal and cardiovascular systems. The predominant blood abnormalities were elevated lipase and alanine aminotransferase values. Insects, food and drugs were the most commonly identified triggers.Conclusions -To the best of our knowledge, this is the first study describing the trigger factors and clinicopathological features of dogs with urticaria in veterinary medicine. Insects, food and drugs were the most frequently detected triggers.

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Section: Introductionmentioning

confidence: 99%

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Rostaher¹,

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2017

Advances in Veterinary Dermatology

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show abstract

“…It is generally agreed that anaphylaxis may occur with or without cutaneous signs, even though these latter signs are frequent and occur in 80–100% of cases . In dogs, the main shock organ is the liver leading to GI signs such as vomiting and diarrhoea (over 90%) . Some GI changes may be due to direct histamine release from the intestine, but are mostly associated with mediator release directly from the liver, as shown in a study with dehepatized dogs .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Rostaher

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2016

Veterinary Dermatology

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Background-Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions. Hypothesis/Objectives-This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria. Animals-Twenty four dogs with signs of urticaria with or without anaphylaxis. Methods-The study included dogs with cutaneous immediate-type hypersensitivity reactions. The cases were grouped by clinical severity into either an urticaria or an anaphylaxis group. All treatments and diagnostic tests (haematology, biochemical profile, allergy investigation) were recorded. A causality algorithm for urticaria and anaphylaxis (ALUA) was designed to determine the probability of the identified triggers and cofactors. Disease incidence, breed, age and gender predispositions were evaluated statistically. Results-Sixteen of 24 urticaria cases were associated with anaphylaxis whilst 8 of 24 were confined to the skin. The annual hospital incidence was 0.12%. Females seemed to be over-represented (2.4:1) and most of the dog breeds were pure breed (22 of 24), with Rhodesian ridgeback, boxer, beagle, Jack Russell terrier, French bulldog and Vizslas over-represented. In addition to skin lesions, the most frequently and severely affected organ systems were the gastrointestinal and cardiovascular systems. The predominant blood abnormalities were elevated lipase and alanine aminotransferase values. Insects, food and drugs were the most commonly identified triggers. Conclusions-To the best of our knowledge, this is the first study describing the trigger factors and clinico-pathological features of dogs with urticaria in veterinary medicine. Insects, food and drugs were the most frequently detected triggers.

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“…Die pathologisch-anatomische Untersuchung der mit Erscheinungen von protrahiertem anaphylaktischem Schock eingegangenen Meerschweinchen ergab Kongestion und Blutungen C i r s t <• a , Über den Entstehungsinecharnsmiis des Spättodes 112 im Magendarmtrakt und in den Lungen, wobei jedoch das für in den ersten Minuten nach der Auslösung gestorbenen Meerschwein chen charakteristische Emphysem nicht vorhanden war (40,46). W ii.liamson (46) und Stone (40) hoben die Ähnlichkeit dieser Läsionen mit jenen hervor, die von D ean und W ebb (10) bei im anaphylaktischen Schock gestorbenen Hunden beschrieben wurden.…”

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Über den Entstehungsmechanismus des Spättodes im anaphylaktischen Schock beim Meerschweinchen

Cîrstea¹

1962

Int Arch Allergy Immunol

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The morbid anatomy and histology of anaphylaxis in the dog

Cited by 36 publications

References 3 publications

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Über den Entstehungsmechanismus des Spättodes im anaphylaktischen Schock beim Meerschweinchen

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