The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital endometriosis

Парамонова, Н. Б.; Kogan, E. A.; Kolotovkina, A V; Burmenskaya, O V

doi:10.17116/patol201880311-18

Cited by 12 publications

(2 citation statements)

References 14 publications

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“…Отмечена повышенная экспрессия ER в железах эндометрия в секреторную фазу цикла при наличии ДОЯ, а уровень PR снижается в течение всего менструального цикла [21,22]. Важно отметить, что стероидные гормоны также оказывают влияние на формирование клеток на поверхности апикальной мембраны пиноподий, количество и степень зрелости которых служат прогностическими факторами успешной имплантации [23]. По процентному числу и степени зрелости пиноподии разделяют на три класса: обильные (более 50%), умеренные (20-50%) и немногочисленные (менее 20%), а также развивающиеся, зрелые и регрессирующие.…”

Section: обоснованиеunclassified

Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Mikhaleva,

Solomatina,

Gashimova

et al. 2023

Morphology

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Background. Currently, there is an increase in benign ovarian tumors, which, according to the results of numerous studies, negatively affect the reproductive health of women. Patients seeking to preserve their reproductive function prefer organ-preserving surgical interventions, however, in clinical practice, adnexectomy is often necessary due to the absence of intact ovarian tissue. Aim. Analysis of the morphofunctional state of the endometrium and its receptivity in patients with serous and mucinous ovarian cystadenomas before and after surgical treatment. Methods. The prospective study included patients of reproductive age with benign epithelial tumors: serous/mucinous cystadenomas who had not received hormonal drugs for six months prior to surgical treatment. 32 patients with serous cystadenoma were included in group I, 30 patients with mucinous cystadenoma in group II. Before and 6-12 months after unilateral salpingo-oophorectomy, a pipel biopsy of the endometrium was performed during the "implantation window". The qualitative and quantitative parameters of pinopodia were studied, the expression of estrogen (ER) and progesterone (PR) receptors in the glands and stroma of the endometrium were studied. Results. In the postoperative period, an increase in the number of mature pinopodia, a growing in the expression of ER in the stroma and PR in the stroma and glands was revealed. When analyzing the data in patients with mucinous cystadenoma After surgical treatment, in patients with mucinous cystadenoma, in comparison with the data of the serous patients in the glandular component of the endometrium, the expression of both ER and PR was lower, and the expression of PR in the stromal component was also lower, a growing in the number of developing pinopodia was recorded. Conclusion. The results of our study showed that benign ovarian tumors is accompanied by disorders of the morphofunctional state and receptivity of the endometrium.

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Section: обоснованиеunclassified

Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Mikhaleva,

Solomatina,

Gashimova

et al. 2023

Morphology

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“…It appears that n-3 PUFAs are associated with estradiol. However, two studies investigating the relationship between maternal intake of n-3 and n-6 PUFAs during pregnancy and estradiol levels did not provide definitive results [ 70 , 71 ].…”

Section: Pufas Sex Hormones and Endometrial Receptivitymentioning

confidence: 99%

Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

et al. 2021

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Endometrial receptivity plays a crucial role in fertilization as well as pregnancy outcome in patients faced with fertility challenges. The optimization of endometrial receptivity may help with normal implantation of the embryo, and endometrial receptivity may be affected by numerous factors. Recently, the role of lipids in pregnancy has been increasingly recognized. Fatty acids and their metabolites may be involved in all stages of pregnancy and play a role in supporting cell proliferation and development, participating in cell signaling and regulating cell function. Polyunsaturated fatty acids, in particular, are essential fatty acids for the human body that can affect the receptivity of the endometrium through in a variety of methods, such as producing prostaglandins, estrogen and progesterone, among others. Additionally, polyunsaturated fatty acids are also involved in immunity and the regulation of endometrial decidualization. Fatty acids are essential for fetal placental growth and development. The interrelationship of polyunsaturated fatty acids with these substances and how they may affect endometrial receptivity will be reviewed in this article.

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