The morphology, size and density of the touch dome in human hairy skin by scanning electron microscopy

Kabata, Yudai; Orime, Mari; Abe, Riichiro; Ushiki, Tatsuo

doi:10.1093/jmicro/dfz001

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…The positional relationship between the stimulus point and the mechanoreceptors changed because the stimulus presentation point was moved by 5 mm in each trial. As mechanoreceptors are not evenly distributed 45,46 and the stimulus point was moved by a distance equivalent to the distance of the twopoint discrimination threshold on the cheek, 8 which is considered to be the receptive field connected to the nerve, the movement of the stimulus presentation point between trials may have produced these perceptual variations. Notably, this phenomenon is common with small skin deformations, and how skin deformations lead to the firing of mechanoreceptors should be investigated.…”

Section: Discussionmentioning

confidence: 99%

The dynamic behavior of skin in response to vibrating touch stimuli affects tactile perception

Sakaguchi

Saito

Arakawa

et al. 2023

Skin Research and Technology

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Background The tactile perceptions arising on the skin mediate representations of the body and perceptions of the external physical world. Thus, these tactile sensations greatly impact our lives. Although tactile perception is caused by skin deformation, few studies have investigated the contribution of skin physical properties to tactile perception because the skin deformation in response to mechanical stimuli is difficult to measure in real time. In this study, we investigated how the skin deforms in response to externally applied mechanical stimuli and the effect of skin deformation on tactile perception. Materials and methods Tactile perception was assessed using psychophysical methods. A suction device was used to measure skin deformation in response to mechanical stimuli while assessing tactile perception. The relationship between skin deformation and tactile perception was investigated. Results Individuals show different skin deformation behavior in response to stimuli of the same intensity, and the amount of skin deformation affects the perceived pressure induced by suction stimulation. Furthermore, when the amount of skin deformation is small, tactile perception becomes more difficult, and the ease of tactile perception varies. Conclusion We argue that dynamic skin behavior is an important factor in tactile perception. Focusing on skin physical characteristics from a constructivist perspective of complex tactile perception may lead to improved tactile communication perception through the control of skin physical properties and realistic tactile presentation in remote environments.

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Section: Discussionmentioning

confidence: 99%

The dynamic behavior of skin in response to vibrating touch stimuli affects tactile perception

Sakaguchi

Saito

Arakawa

et al. 2023

Skin Research and Technology

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“…Human TDs appear as irregularly shaped rounded elevations that, in contrast to those in animals, are inconsistently associated with hair follicles. 46 On average, one human TD is present per 5 hair follicles. 47,48 It remains entirely speculative if and how a pluripotent stem cell may contribute to the development of a specific subset of dermal and intraepidermal MCCs.…”

Section: Discussionmentioning

confidence: 99%

Dermal and Intraepidermal Merkel Cell Carcinoma With Squamous Cell Carcinoma: A Report of a Rare Case With Special Reference to the Touch Dome

Narisawa

Inoue

Nagase

2020

The American Journal of Dermatopathology

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In skin containing hair follicles, specialized epithelial structures known as "touch domes (TDs)" are located where the Merkel cells are clustered. We explored the histogenetic relationship between intraepidermal and dermal Merkel cell carcinomas (MCCs) and investigated which transformed progenitor cells can develop into intraepidermal MCC. We encountered an association between an extremely rare case of dermal and intraepidermal MCC with squamous cell carcinoma, which was examined using standard immunohistochemical methods with various epithelial, neuroendocrine, and TD markers including several immunohistochemical markers. Differential expression levels of CK20 and CD56 were found between intraepidermal and dermal MCCs, indicating molecularly distinct MCC populations. CK15 and CK17, expressed in TDs, were partially expressed in the intraepidermal neuroendocrine component at the tumor periphery in intraepidermal MCC with squamous cell carcinoma. These differences may suggest that the origin of dermal and intraepidermal MCCs is different under pathological conditions. We hypothesize that intraepidermal MCC is derived from tissue-specific stem cells localized within TDs.

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“…They show extreme sensitivity (in tens of nanometers of membrane displacement) and a particular phase-locking physiological response to oscillating stimuli. The fourth type of response observed from the human hand, when large regions of glabrous skin are pulled sideways elicit a steady response in a comparatively small number of nerve fibers, is thought to be due to a population of endorgans called Ruffini endings [34]. Astonishingly, there is no modern observation of these organs in the hand (yet, they are observed in other connective tissues, such as ligaments).…”

Section: H I S T O R I C a L D E V E L O P M E N T S R E L At E Dmentioning

confidence: 99%

Large-Area Soft e-Skin: The Challenges Beyond Sensor Designs

et al. 2019

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The morphology, size and density of the touch dome in human hairy skin by scanning electron microscopy

Cited by 7 publications

References 9 publications

The dynamic behavior of skin in response to vibrating touch stimuli affects tactile perception

The dynamic behavior of skin in response to vibrating touch stimuli affects tactile perception

Dermal and Intraepidermal Merkel Cell Carcinoma With Squamous Cell Carcinoma: A Report of a Rare Case With Special Reference to the Touch Dome

Large-Area Soft e-Skin: The Challenges Beyond Sensor Designs

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