The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

Abstract

We are presenting 2 cases where ozone therapy was used in the form of ozonated oil on an exophytic fibrous gingival lesion. A 42-years female patient was selected, who presented with a mild to moderately painful, exophytic, fibrous lesion on the upper anterior gingiva. This gingival lesion was treated with 2ml of ozonated oil, thrice daily for one week. After the ozone therapy, the postoperative outcomes were measured and analyzed. Finally, the lesion was subjected to an excisional biopsy and a histopathological evaluation. After the ozone therapy, the patient revealed that there was less pain. On examination of the lesion, an improvement was observed in the clinical sign of the inflammation and also a reduction in the surface ulceration. During the final biopsy, less bleeding was observed. The morphometrical analysis showed a reduction in the size of the lesion. The histopathological analysis showed a reduction in the collagen fibres and in the inflammatory cells in the connective tissue stroma. Topical ozone therapy provides potential benefits for the treatment of exophytic gingival lesions. The observed benefits in present case report needs to be verified in future with well-controlled clinical trials.

Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial

“…Ozonized gel, contains stable ozonide which, when in contact with the wound (body temperature), decomposes to reactive active ozone in a prolonged way [21]. We believe that the application of ozone coincided with the peak of inflammation, which may have significantly reduced post-operative oedema in the study group [21]. The present study applied ozonized double distilled water only in the transoperative period, with no further post-operative complementation, which may have influenced this result.…”

“…Ozonized gel applied to the surgical wound for 2 min, twice daily for 3 days, decreased operative pain, oedema and trismus [17]. Ozonized gel, contains stable ozonide which, when in contact with the wound (body temperature), decomposes to reactive active ozone in a prolonged way [21]. We believe that the application of ozone coincided with the peak of inflammation, which may have significantly reduced post-operative oedema in the study group [21].…”

Comparative evaluation of effects of subgingival application of ozonated olive oil versus chlorhexidine in patients with chronic periodontitis: A clinico- microbiological randomised trial

“…20 Ozonated oils are obtained from the chemical reaction between ozone and unsaturated fatty acids of vegetable oils. 21,22 Due to its excellent curative results, simple application, long-term effects, and nontoxic nature they are widely being used.…”

Yumuşak Doku Yaralanması Sonrası Ozon Tedavisinin Etkileri ve IGF-1 Seviyesiyle Olan İlişkisi: Rat Modelinde Deneysel Bir Çalışma

“…Impact of ozone treatment on wound healing has been studied in current literature [18,19] . However, the effects of ozone on a soft tissue injury model and its relationship with IGF-1 levels had not been reported in an experimental rat model.…”

“…Ozone may result in increased angiogenesis and facilitate re-establishment of vascularization in the connective tissue. Thereby, improvement of oxygen and nutrient supply will enhance wound healing and repair of injury at the site of injury [18,19] . The precise mechanisms underlying these activities may be linked with antimicrobial property of ozone as well as amplification of the immune response through release of growth factors, interferons and interleukins [20] .…”