The mouse ligth-dark paradigm: A review

Hascoët, Martine; Bourin, Michel; Dhonnchadha, Brı́d Áine Nic

doi:10.1016/s0278-5846(00)00151-2

Cited by 197 publications

(109 citation statements)

References 62 publications

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“…Both paradigms are used for measuring state anxiety that is based on the conflict between exploration of novel environments and the avoidance of potentially dangerous situations (Hogg, 1996;Rodgers and Dalvi, 1997;Hascoet et al, 2001;Millan et al, 2003;de Sousa et al, 2006). TRPV1-KO much faster adapted to the aversive light compartment, spent more time in the light compartment in the light-dark test, and explored the open arms of the elevated plus maze more intensively than their wild-type littermates, indicating that they are less anxious.…”

Section: Discussionmentioning

confidence: 99%

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Marsch¹,

Foeller²,

Rammes³

et al. 2007

J. Neurosci.

317

230

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The transient receptor potential vanilloid type 1 channel (TRPV1) (formerly called vanilloid receptor VR1) is known for its key role of functions in sensory nerves such as perception of inflammatory and thermal pain. Much less is known about the physiological significance of the TRPV1 expression in the brain. Here we demonstrate that TRPV1 knock-out mice (TRPV1-KO) show less anxiety-related behavior in the light-dark test and in the elevated plus maze than their wild-type littermates with no differences in locomotion. Furthermore, TRPV1-KO mice showed less freezing to a tone after auditory fear conditioning and stress sensitization. This reduction of conditioned and sensitized fear could not be explained by alterations in nociception. Also, tone perception per se was unaffected, as revealed by determination of auditory thresholds through auditory brainstem responses and distortion-product otoacoustic emissions. TRPV1-KO showed also less contextual fear if assessed 1 d or 1 month after strong conditioning protocols. These impairments in hippocampusdependent learning were mirrored by a decrease in long-term potentiation in the Schaffer collateral-commissural pathway to CA1 hippocampal neurons. Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Marsch¹,

Foeller²,

Rammes³

et al. 2007

J. Neurosci.

317

230

View full text Add to dashboard Cite

show abstract

“…The subject was placed in the light box and its location was recorded for 5 min. The time spent in the light side of apparatus was considered the primary measure of the anxiety because of its sensitivity to anxiolytics (Hascoët et al, 2001). Light box entry was defined as the mouse having all four paws into the light box.…”

Section: Open Fieldmentioning

confidence: 99%

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.

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“…The light-dark exploration paradigm, which is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behavior of the animals, is used primarily to detect anxiogenic behavior (Hascoet et al, 2001). GAT1 À/À mice spent significantly less time in the dark chamber than wild-type mice (F(2,43) ¼ 8.38, po0.001) (Figure 2b), and made more transitions (F(2,43) ¼ 6.97, p ¼ 0.002) (Figure 2a), suggesting a reduction in anxiety-like behavior.…”

Section: Reduced Anxiety-like Behaviors In Gat1 Knockout Micementioning

confidence: 99%

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

Liu

Cai

et al. 2006

Neuropsychopharmacol

118

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g-Aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contributions of the GAT1 in regulating mental status are not fully understood. In this paper, we observed the behavioral alterations of GAT1 knockout (GAT1 À/À ) mice using several depressionand anxiety-related models (eg, the forced-swimming test and the tail-suspension test for testing depression-related behaviors; the openfield test, the dark-light exploration test, the emergence test, and the elevated plus maze (EPM) test for anxiety-related behaviors). Here we found that GAT1 À/À mice showed a lower level of depression-and anxiety-like behaviors in comparison to wild-type mice. Furthermore, GAT1 À/À mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail-suspension test and/or the EPM test. Moreover, the basal level of corticosterone was found to be significantly lower in GAT1 À/À mice. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice.

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The mouse ligth-dark paradigm: A review

Cited by 197 publications

References 62 publications

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Reduced Anxiety and Depression-Like Behaviors in Mice Lacking GABA Transporter Subtype 1

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