The MSC curtain that stops the immune system

Caplan, Arnold I.; Sorrell, J. Michael

doi:10.1016/j.imlet.2015.06.005

Cited by 90 publications

(75 citation statements)

References 59 publications

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“…They produce a curtain of activities behind which tissue regeneration is operable. These range of activities led Arnold Caplan to suggest changing the "MSC" acronym to "medicinal signaling cells" [163] . Cotransplantation of islets and MSCs seeded on naked scaffold enhanced islet function [164,165] , and similar advantage were de monstrated following coencapsulation of islets and MSCs [166,167] .…”

Section: Controlling Inflammationmentioning

confidence: 99%

Survival of encapsulated islets: More than a membrane story

Barkai¹,

Rotem²,

Vos³

2016

WJT

116

109

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Section: Controlling Inflammationmentioning

confidence: 99%

Survival of encapsulated islets: More than a membrane story

Barkai¹,

Rotem²,

Vos³

2016

WJT

116

109

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“…However, heterogeneity between MSCs from different donors is high [42] as demonstrated by variability between growth properties and osteogenic potential; furthermore, their capacity to proliferate and differentiate declines considerably with increasing patient age [43,44]. MSCs are also considered to have an immunomodulatory capacity, and there is evidence to suggest that in vivo their primary function is modulation of repair rather than differentiation into tissue-specific cells, which then contribute directly to tissue regeneration [45].…”

Section: Myopathiesmentioning

confidence: 99%

Augmentation of Musculoskeletal Regeneration: Role for Pluripotent Stem Cells

2018

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The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to pluripotent stem cells (PSCs), namely, human embryonic stem cells and human-induced PSCs, due to the limited success of adult stem cell-based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarizes methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.

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“…Another important characteristic of pericytes that can be inferred from their relationship to MSCs is the ability to secrete molecules that interfere with the action of immune system cells, blocking inflammation [156]. However, it should be noted that pericytes do not become activated immediately upon TBI, and during the initial stages of the response to this injury, they may contribute to the recruitment of inflammatory cells.…”

Section: Pericytes In the Traumatic Penumbramentioning

confidence: 99%

Traumatic Penumbra: Opportunities for Neuroprotective and Neurorestorative Processes

Regner¹,

Meirelles²,

Simon³

2018

Traumatic Brain Injury - Pathobiology, Advanced Diagnostics and Acute Management

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Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. Understanding the pathophysiology of TBI is crucial for the development of more effective therapeutic strategies. At the moment of the traumatic impact, transfer of kinetic forces causes neurologic damage; this primary injury triggers a secondary wave of biochemical cascades, together with metabolic and cellular changes, called secondary neural injury. These areas of ongoing secondary injury, or areas of "traumatic penumbra," represent crucial targets for therapeutic interventions. This chapter is focused on the interplay between progression of parenchymal injury and the neuroprotective and neurorestorative processes that are emerging and developing subsequently to traumatic impact. Thus, we emphasized the role of traumatic penumbra in TBI pathogenesis and suggested a crucial contribution of the neurovascular units (NVUs) and paracrine effects of exosomes and miRNAs in promoting neurological recovery.

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The MSC curtain that stops the immune system

Cited by 90 publications

References 59 publications

Survival of encapsulated islets: More than a membrane story

Survival of encapsulated islets: More than a membrane story

Augmentation of Musculoskeletal Regeneration: Role for Pluripotent Stem Cells

Traumatic Penumbra: Opportunities for Neuroprotective and Neurorestorative Processes

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