The multifaceted and controversial immunometabolic actions of adiponectin

Esmaili, Saeed; Xu, Amin; George, Jacob

doi:10.1016/j.tem.2014.06.001

Cited by 53 publications

(37 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adiponectin has been proposed to be a cytokine with protective properties, but surrounded by controversy 17,33,34 . Recently, it has emerged an interestingly facet showing that adiponectin is also a myokine, being produced and released by skeletal muscle 10 .…”

Section: Discussionmentioning

confidence: 99%

“…We have included BMI as covariate in our models due to better associative power with adiponectin levels than other adiposity variables such as waist circumference and, body fat percentage estimated by bioelectrical impedance and skinfolds thickness (data not showed). In this line of thought, a recent review observed that currently, most of the knowledge on the roles of adiponectin is driven from studies with obese subjects or in subjects with metabolic syndrome, a pathological host milieu; and, to clarify the context-dependent and homeostasis roles of adiponectin studies in both pathological and normal physiological states are needed 33 . Once, it seems clear that circulating adiponectin levels are reduced in obese subjects, several studies, as well as our results have demonstrated this.…”

Section: Discussionmentioning

confidence: 99%

“…First, our cross-sectional design does not allow us to establish causality. Second, the measured serum adiponectin levels result from its release from several adipose and non-adipose tissues 33 , so it should be questioned to what extent skeletal muscle may contribute to these levels, and thus, to provide a wider insight on the relationship between MF and serum adiponectin levels in adolescents. Nonetheless, it has been shown that high circulating adiponectin concentration may be an indicator of decreased physical performance, especially muscle strength, in older adults 40 .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

Agostinis‐Sobrinho

Santos

Moreira

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Background and aim: Paradoxically, recent investigations have showed that adiponectin levels are inversely associated with muscle strength. However, to date, there is a lack of knowledge on the relationship between muscular fitness (MF) and adiponectin levels in adolescents. We aimed to examine the independent associations between MF and adiponectin levels in adolescents, controlling for several potential confounders. Methods and results: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. A MF score was computed as the mean of the handgrip strength and standing long jump standardized values by age and gender. We measured fasting glucose, insulin, HDL-cholesterol, C-reactive protein and adiponectin. Linear regression analysis showed a significant inverse association between adiponectin (Z-score by age and sex) and MF score, after adjustments for age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, body mass index, HOMA-IR, HDL-cholesterol, C-reactive protein and cardiorespiratory fitness (unstandardized β = -0.176; p < 0.005). Analysis of covariance showed a significant difference between the Low MF/Non-overweight group and the High MF/Non-overweight Group (p < 0.05) and between the Low MF/Non-overweight and High MF/Overweight Group (p < 0.05) (F (5, 523) = 2.262, p = 0.047). Conclusion: Adiponectin circulating levels are inversely and independently associated with MF. In nonoverweight adolescents, those with high levels of MF presented lower levels of adiponectin compared to those with Low MF. Likewise, overweight adolescents with High MF presented lower levels of serum adiponectin than non-overweight adolescents with Low MF.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

Agostinis‐Sobrinho

Santos

Moreira

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

show abstract

“…Similar to other collectins, including C1q and surfactant proteins A and D, adiponectin facilitates apoptotic cell uptake ("efferocytosis"), which is dysregulated in smoking and COPD (8). These properties lead most authorities to consider adiponectin to be antiinflammatory and cardioprotective, despite some conflicting data (9).…”

mentioning

confidence: 99%

“…Limitations are the single measurement of plasma adipokines; its acknowledged overwhelming male population, which precluded replication of the interaction between female sex and body mass index on the leptin/fat mass ratio in COPD (13); and potentially that the ELISA employed measures immunoreactive to adiponectin, whereas bioactivity in vivo varies with multimeric state (9).…”

mentioning

confidence: 99%

Queens Beat One-Eyed Jacks, but Nobody’s Played the Ace Yet. Adipokines as Chronic Obstructive Pulmonary Disease Biomarkers

Curtis

2015

Annals ATS

View full text Add to dashboard Cite

Circadian Rhythms in Adipose Tissue Physiology

Kiehn

Tsang

Heyde

et al. 2017

Comprehensive Physiology

View full text Add to dashboard Cite

The different types of adipose tissues fulfill a wide range of biological functions-from energy storage to hormone secretion and thermogenesis-many of which show pronounced variations over the course of the day. Such 24-h rhythms in physiology and behavior are coordinated by endogenous circadian clocks found in all tissues and cells, including adipocytes. At the molecular level, these clocks are based on interlocked transcriptional-translational feedback loops comprised of a set of clock genes/proteins. Tissue-specific clock-controlled transcriptional programs translate time-of-day information into physiologically relevant signals. In adipose tissues, clock gene control has been documented for adipocyte proliferation and differentiation, lipid metabolism as well as endocrine function and other adipose oscillations are under control of systemic signals tied to endocrine, neuronal, or behavioral rhythms. Circadian rhythm disruption, for example, by night shift work or through genetic alterations, is associated with changes in adipocyte metabolism and hormone secretion. At the same time, adipose metabolic state feeds back to central and peripheral clocks, adjusting behavioral and physiological rhythms. In this overview article, we summarize our current knowledge about the crosstalk between circadian clocks and energy metabolism with a focus on adipose physiology. © 2017 American Physiological Society. Compr Physiol 7:383-427, 2017.

show abstract

The multifaceted and controversial immunometabolic actions of adiponectin

Cited by 53 publications

References 72 publications

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

Queens Beat One-Eyed Jacks, but Nobody’s Played the Ace Yet. Adipokines as Chronic Obstructive Pulmonary Disease Biomarkers

Circadian Rhythms in Adipose Tissue Physiology

Contact Info

Product

Resources

About