The Multiple Sclerosis Intimacy and Sexuality Questionnaire — re-validation and development of a 15-item version with a large US sample

Foley, Frederick W.; Zemon, Vance; Campagnolo, Denise I.; Marrie, Ruth Ann; Cutter, Gary; Tyry, Tuula; Beier, Meghan; Farrell, Eileen; Vollmer, Timothy; Schairer, Laura C.

doi:10.1177/1352458512471876

Cited by 78 publications

(59 citation statements)

References 21 publications

(28 reference statements)

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“…Subtle neurological disturbances can directly affect sexual function at a time of life when it assumes particular importance for many people. MS can also affect sexual function indirectly through other physical disabilities such as spasticity or bladder dysfunction, as a side effect of medications and through psychosocial mechanisms such as the presence of depression [2]. Disturbed sexual function can have detrimental effects particularly on partner relationships and mental health-related quality of life, well demonstrated in a large North American Research Committee on Multiple Sclerosis (NARCOMS) Registry sample of 6,183 PwMS [3].…”

Section: Introductionmentioning

confidence: 99%

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

et al. 2016

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BackgroundSexual dysfunction (SD) is very common in people with multiple sclerosis (PwMS) and contributes a significant burden of disease, particularly for young people. SD has direct neurological contributions from depression and fatigue, which occur commonly in PwMS. Modifiable factors may represent potential targets for treatment and prevention of SD. We aimed to assess the prevalence of SD and explore associations between SD and demographic and modifiable risk factors, as well as depression and fatigue in a large cohort of PwMS.MethodsWe analysed self-reported data from a large, international sample of PwMS recruited via Web 2.0 platforms, including demographic, lifestyle and disease characteristics. Specific sexual function questions included 4 items from the sexual function scale and 1 item regarding satisfaction with sexual function, part of the MS Quality of Life-54 instrument.Results2062 PwMS from 54 countries completed questions on sexual function. 81.1 % were women, mean age was 45 years, most (62.8 %) reported having relapsing-remitting MS. The majority (54.5 %) reported one or more problems with sexual function and were classified as having SD. Lack of sexual interest (41.8 % of women), and difficulty with erection (40.7 % of men) were most common. The median total sexual function score was 75.0 out of 100, and 43.7 % were satisfied with their sexual function. Regression modeling revealed independent associations between sexual function and satisfaction and a range of demographic factors, including age, as well as depression risk, antidepressant use, and fatigue in PwMS.ConclusionThis cross-sectional study shows that SD and lack of satisfaction with sexual function are associated with depression risk and fatigue, as well as modifiable lifestyle factors diet and physical activity (after adjusting for depression and fatigue). Planned longitudinal follow-up of this sample may help clarify these associations and the underlying mechanisms. There is potential to prevent and treat SD in PwMS by addressing depression and fatigue and their determinants. Clinicians and PwMS should be aware of SD and associated factors as part of a comprehensive preventive approach to managing MS.

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Section: Introductionmentioning

confidence: 99%

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

et al. 2016

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“…The MSISQ-19 was previously used as a tool to evaluate SD in MS 8 ; Foley has recently developed and validated a version with 15 items of the scale based on a large sample of North American patients 9 .…”

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confidence: 99%

Validation and cross-cultural adaptation of sexual dysfunction modified scale in multiple sclerosis for Brazilian population

Silva

Olival

Stievano

et al. 2015

Arq. Neuro-Psiquiatr.

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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). These patients suffer from various comorbidities, including sexual dysfunction (SD). The lesions of MS may affect regions of the CNS along the pathway of sexual response. The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a scale that assesses sexual dysfunction. Adapt and validate the MSISQ-19 to Brazilian patients with MS. 204 individuals were evaluated, 134 patients with MS and 70 healthy persons for the control group. It was determined reproducibility, validity, internal consistency and sensitivity of the MSISQ-19-BR. Among patients with MS, 54.3% of male and 71.7% of female presented some kind of SD. In the control group the results were 12.5% and 19.5%, respectively. The MSISQ-19-BR is reproducible, reliable and valid for the Brazilian population and may be used as a tool for assessing the impact of sexual dysfunction in patients with MS.

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“…MS-related SD can be divided into: (i) primary, i.e. directly due to MS-related neurologic deficits affecting the sexual response, (ii) secondary, which is attributed to MS-related physical impairments and symptoms that affect indirectly the sexual response, including spasticity and contractures, fatigue, bladder dysfunction and cognitive symptoms; (iii) tertiary, SD that is caused by the psychological, social and cultural issues of having a chronic disabling disease that affects sexual functioning [2,4]. Thus, because of the multifactorial nature of sexual problems in individuals with MS, regular multidisciplinary evaluation including neurologist, urologist and psychologist is needed while managing these patients and their partners.…”

mentioning

confidence: 99%

“…Thus, because of the multifactorial nature of sexual problems in individuals with MS, regular multidisciplinary evaluation including neurologist, urologist and psychologist is needed while managing these patients and their partners. To this end, proper questionnaire scores, such as the Multiple Sclerosis Intimacy and Sexuality Questionnaire [4], should be included as an additional outcome measure in evaluating MS patient disability.…”

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confidence: 99%

Sexual dysfunction in multiple sclerosis: still a neglected problem?

Calabrò

Bramantı

2013

Disability and Rehabilitation

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The Multiple Sclerosis Intimacy and Sexuality Questionnaire — re-validation and development of a 15-item version with a large US sample

Abstract: The revised 15-item MSISQ is a reliable and valid measure of sexual dysfunction in men and women with MS.

Cited by 78 publications

References 21 publications

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

Validation and cross-cultural adaptation of sexual dysfunction modified scale in multiple sclerosis for Brazilian population

Sexual dysfunction in multiple sclerosis: still a neglected problem?

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