The Mycetoma Research Centre experience during the COVID-19 pandemic: obstacles and beyond

Fahal, Lamis Ahmed; Ahmed, Eiman Siddig; Bakhiet, Sahar Mubarak; Siddig, Emmanuel Edwar; Fahal, Ahmed Hassan

doi:10.1093/trstmh/trab111

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Nevertheless, to guide interested readers as well as to pool literature related to pneumonia among Sudanese population and for further research prospect, all related articles according to the current search strategy are depicted in (Table 2). Abd El-Raheem et al [28] Characteristics and severity of COVID-19 among Sudanese patients during the waves of the pandemic Abdelmagid et al [29] Acceptability and feasibility of strategies to shield the vulnerable during the COVID-19 outbreak: a qualitative study in six Sudanese communities Abdou et al [30] The coronavirus disease 2019 (COVID-19) vaccination psychological antecedent assessment using the Arabic 5c validated tool: An online survey in 13 Arab countries Abouzid et al [31] Influence of COVID-19 on lifestyle behaviors in the Middle East and North Africa Region: a survey of 5896 individuals Ahmed et al [32] Impact of the COVID-19 pandemic on intimate partner violence in Sudan, Malawi and Kenya Ahmed et al [33] COVID-19 in Sudan Ahmed et al [34] Clinical characteristics, complications, and predictors of outcome of hospitalized adult Sudanese patients with COVID-19 and malaria coinfection in Sudan: A multicenter retrospective cross-sectional study Ahmed et al [35] Controlling the spread of COVID-19 in Sudan with limited resources: a unique community-engaged approach Ali et al [36] The role of integrated programs in the prevention of COVID-19 in a humanitarian setting Aljak et al [37] The first laboratory-confirmed imported infections of SARS-CoV-2 in Sudan Attaallah et al [38] The Prognostic Value of Thrombocytopenia in COVID-19 Pneumonia, Gezira Isolation Centers, Sudan Aung et al [39] Community responses to COVID-19 pandemic first wave containment measures: a multinational study Bara'a et al [40] Coronavirus 2019-like illness and public adherence to preventive measures, Sudan 2020 Deek et al [41] A multi-centric study on validation of the Fear Scale for COVID-19 in five Arabic speaking countries Elagib et al [42] Knowledge, attitude, and practice regarding infection control measures among dental students during COVID-19 pandemic Elhadi et al [43] The formidable task of fighting COVID-19 in Sudan El-Sadig et al [44] Obstacles faced by healthcare providers during COVID-19 pandemic in Sudan El-Sadig et al [45] Impact of COVID-19 on doctors and healthcare providers during the pandemic in Sudan Fahal et al [46] The Mycetoma Research Centre experience during the COVID-19 pandemic: obstacles and beyond Gayawan et al [47] The spatio-temporal pandemic dynamics of COVI...…”

Section: Covid 19 Studiesmentioning

confidence: 99%

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Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Mohamed

SalahEldin

Idris

et al. 2022

Preprint

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In addition to excessive burden of non-communicable diseases, natural and manmade disasters and internal conflicts, Sudan is predominantly susceptible to communicable diseases such as Malaria, Tuberculosis, and Pneumonia, which bring about a burden of infectious diseases and demand for high quality health care. According to the WHO as well as the Sudan Health Observatory, Pneumonia is one of the leading causes of death in Sudan. This study therefore aimed to determine pneumonia infection prevalence among Sudanese as well as its related risk factors. A systematic review of the literature was conducted in the 1st of December 2020. The review was regulated in accordance with PRISMA. After abstract and full text screening only seventeen articles met our inclusion criteria and passed the quality assessment procedure. Seven included studies determined prevalence of pneumonia; the overall pooled prevalence was around 30%. Furthermore, twelve research articles investigated risk factors related to pneumonia among Sudanese population. Further research with larger sample sizes targeting risk factors of pneumonia among Sudanese population is needed to be conducted. Keywords Africa, Developing countries, Risk, STIs, sub-Saharan Africa

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Section: Covid 19 Studiesmentioning

confidence: 99%

“…Impact of COVID-19 on doctors and healthcare providers during the pandemic in Sudan Fahal et al [46] 2022 The Mycetoma Research Centre experience during the COVID-19 pandemic: obstacles and beyond Gayawan et al [47] 2020…”

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confidence: 99%

Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Mohamed

SalahEldin

Idris

et al. 2022

Preprint

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“…These visual ethnographic films document the stories of two mycetoma patients and their families journeys with the disease and their unfortunate and depressing experiences and then the COVID-19 pandemic effects until the patients’ legs were amputated. 4 , 5 The films then captured their recovery and a postoperative period as disabled persons with an amputation, waiting for a prosthesis that would allow them to start a new life. Despite his obvious sadness, low spirits and depression, El Safi regularly visits the MRC, mixing with and singing for the patients to improve their morale, encouraging them to continue their treatment and follow-up to avoid having the same sad outcome as he had.…”

Section: Patients’ Storiesmentioning

confidence: 99%

Visual ethnographic documentation: a novel tool for mycetoma awareness and advocacy

Fahal

Otieno

Ahmed

et al. 2022

Transactions of the Royal Society of Tropical Medicine and Hygiene

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“…Mycetoma is a chronic subcutaneous granulomatous, inflammatory and debilitating neglected disease [ 1 ]. It is classified into eumycetoma and actinomycetoma, depending on whether the causative agent is fungal or actinobacteria, respectively.…”

Section: Introductionmentioning

confidence: 99%

Metagenomic detection of eumycetoma causative agents from households of patients residing in two Sudanese endemic villages in White Nile State

et al. 2022

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Eumycetoma is a chronic debilitating fungal disease endemic to tropical and subtropical regions, with Sudan featuring the highest eumycetoma incidence. Among the 50 species of fungi most commonly associated with eumycetoma Madurella mycetomatis (M. mycetomatis) is often referenced as the most common pathogen. However, there is an enormous knowledge gap related to this neglected disease and its pathogenesis, epidemiological features, and host-specific factors that could contribute to either the host susceptibility and resistance. In this study, we were able to utilize a metagenomic approach and samples collected from clinical black grains (BG) and familiar household environments aimed to assay both the habitat of eumycetoma-associated fungi and its possible connection with eumycetoma patients living in two different eumycetoma endemic villages within the White Nile State of Sudan. DNA sequencing targeting the fungal ITS2 domain was performed on soil, animal dung, housing walls and roofs, and Acacia-species thorn samples and compared with culture-dependent methods of fungal isolation. Additionally, we compared the soil samples obtained in the endemic zone with that from non-endemic zones, including Wagga village in Kassala State and Port Sudan suburb in Port Sudan State. Overall, a total of 392 Amplicon Sequence Variants (ASVs) were detected by ITS2 metagenomics Eumycetoma causative organisms accounted for 10% of total ASVs which included 11 genera: Exserohilum (2%), Aspergillus (1.7%), Curvularia (1%), Alternaria (0.9%), Madurella (0.5%), Fusarium (0.4%), Cladosporium (0.2%) Exophiala (0.15%), and, in a lesser extent, Microascus (0.05%) Bipolaris and Acremonium (0.01%) for each. Only five genera were identified by culture method, which included Fusarium (29%), Aspergillus (28%), Alternaria (2.5%), Bipolaris (1.6%), and Chaetomium (0.8%). M. mycetomatis was detected within all the studied patients’ houses, accounting for 0.7% of total sequences. It was the first common eumycetoma-associated agent detected in soil samples and the third common in the dung and wall samples. In contrast, it was not detected in the roof or thorn samples nor in the soils from non-endemic regions. Exserohilum rostratum, Aspergillus spp and Cladosporium spp were detected in all samples. M. mycetomatis and other eumycetoma-associated fungal identified in the patients’ black grains (BG) samples by metagenomics were identified in the environmental samples. Only Acremonium alternatum and Falciformispora senegalensis, responsible for eumycetoma in two patients were not detected, suggesting the infections in these patients happened outside these endemic areas. The soil, animal dung, and houses built from the same soil and dung are the main risk factors for M. mycetomatis infection in these endemic villages. Furthermore, the poor hygienic and environmental conditions, walking barefooted, and the presence of animals within the houses increase the risk of M. mycetomatis and other fungi causing eumycetoma.

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The Mycetoma Research Centre experience during the COVID-19 pandemic: obstacles and beyond

Cited by 5 publications

References 8 publications

Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Visual ethnographic documentation: a novel tool for mycetoma awareness and advocacy

Metagenomic detection of eumycetoma causative agents from households of patients residing in two Sudanese endemic villages in White Nile State

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