The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain

Burchett, Scott A.; Hicks, T.P.

doi:10.1016/j.pneurobio.2006.07.003

Cited by 186 publications

(156 citation statements)

References 207 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…It is well known that β-phenylethylamine is related to catecholamine release (Mesfioui et al, 1998;Nakamura et al, 1998;Burchett and Hicks, 2006). Recently, Xie and Miller (2004) reported that β-phenylethylamine inhibited noradrenaline uptake and induced efflux of noradrenaline through trace amine-associated receptor 1, which exists in the brainstem and other brain regions, including the prefrontal cortex (Bunzow et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…A main substance of MAO-B, β-phenylethylamine, exists in the brain; it is related to catecholamine release (Mesfioui et al, 1998;Nakamura et al, 1998;Burchett and Hicks, 2006). Accordingly, we also measured extracellular noradrenaline and serotonin levels after local infusion of β-phenylethylamine to the mPFC of rats.…”

Section: Consequently Mao Inhibitors Have Been Used Only Infrequentlmentioning

confidence: 99%

See 1 more Smart Citation

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

Kitaichi

Inoue

Nakagawa

et al. 2010

European Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Consequently Mao Inhibitors Have Been Used Only Infrequentlmentioning

confidence: 99%

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

Kitaichi

Inoue

Nakagawa

et al. 2010

European Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…At even higher concentrations TAs enhance DA release, and to a lesser extent NE and 5-HT, into synapses. The effects evoked at these high TA concentrations have been referred to as "amphetamine-like" (Berry, 2005;Burchett & Hicks, 2006).…”

Section: Biological Actions Of Trace Aminesmentioning

confidence: 99%

“…In their review of the subject Burchett & Hicks (2006) suggest that when the classical actions of TAs are considered together with the recent discovery of vertebrate receptors activated by TAs (Borowsky et al, 2001;Bunzow et al, 2001) the evidence suggests four kinds of TA activity in the CNS: co-transmitters released with DA, NE, and 5-HT; transmitters in their own right with their own receptors; false transmitters at DA-and NE-selective receptors; and neuromodulators hence the name protean neurotransmitters.…”

Section: 42mentioning

confidence: 99%

“…Historically it has been these notable manifestations of extracts prepared from ergot and putrfied meat that originally motivated physiologists, pharmacologists, and medicinal chemists to better understand the mechanism(s) by which the TAs act. The recent cloning of vertebrate metabotropic G protein-coupled receptors (GPCRs) activated by TAs provides an ecixting new opportunity that promises to expand our comprehension of the biological roles these simple but fascinating compounds play (reviewed in Premont et al, 2001;Kim & von Zastrow, 2001;Branchek & Blackburn, 2003;Davenport, 2003;Berry, 2004;Burchett & Hicks, 2006;Lewin, 2006;Zucchi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

179

211

View full text Add to dashboard Cite

Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the 'trace amines' (TAs) β-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of two publications that appeared in 2001 describing the cloning of a novel G protein-coupled receptor (GPCR) referred to by their discoverers as TA1 (Borowsky et al., 2001) and TAR1 (Bunzow et al., 2001). When heterologously expressed in Xenopus laevis oocytes and various eukaryotic cell lines recombinant rodent and human TA receptors dosedependently couple to the stimulation of cAMP production. Structure-activity profiling based on this functional response has revealed that in addition to the TAs, other biologically active compounds containing a 2 carbon aliphatic side chain linking an amino group to at least one benzene ring are potent and efficacious TA receptor agonists with amphetamine, methamphetamine, 3-iodothyronamine, thyronamine, and dopamine among the most notable. Almost 100 years after the search for TA receptors began numerous TA1/TAR1-related sequences, now called Trace AmineAssociated Receptors (TAARs), have been identified in the genome of every species of vertebrate examined to date. Consequently, even though heterologously expressed TAAR1 fits the pharmacological criteria established for a bona fide TA receptor a major challenge for those working in the field is to discern the in vivo pharmacology and physiology of each purported member of this extended family of GPCRs. Only then will it be possible to establish whether TAAR1 is the family archetype or an iconoclast.

show abstract

Maternal Exposure to Magnetic Fields During Pregnancy in Relation to the Risk of Asthma in Offspring

Chen²,

Odouli³

2011

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

show abstract

The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain

Cited by 186 publications

References 207 publications

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine

Trace amine-associated receptor 1—Family archetype or iconoclast?

Maternal Exposure to Magnetic Fields During Pregnancy in Relation to the Risk of Asthma in Offspring

Contact Info

Product

Resources

About