The Naphthyridines.

Allen, C. F. H.

doi:10.1021/cr60147a004

Cited by 59 publications

(17 citation statements)

References 24 publications

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“…The effect on prostaglandin E 2 (PGE 2 ) and prostacyclin production by human umbilical vascular endothelial cells (HUVEC), production of reactive oxygen species (ROS) by PMNs and PMN adhesion to HUVEC were investigated. Results showed no effect of these compounds on the production of PGE 2 [124]. Our group has specifically explored 1,8-naphthyridine-3-carboxamide derivatives for in vitro anti-inflammatory activity via modulation of the cytokine arm.…”

Section: Antiviral Activity (Hiv/hcv)mentioning

confidence: 99%

“…The N-monosubstituted 5-aminoderivatives seemed to be more potent anti-inflammatory agents than the corresponding N,N-disubstituted derivatives, whereas the latter compounds exhibited higher analgesic activity [119]. The in vitro anti-inflammatory activity of shortlisted 1,8-derivatives belonging to [1,2,4]triazolo [4,3-a] [1,8]naphthyridine class was studied by Dianzani and coworkers [120] in 2006 using human stimulated human polymorphonuclear cells (PMN) and endothelial cells. The effect on prostaglandin E 2 (PGE 2 ) and prostacyclin production by human umbilical vascular endothelial cells (HUVEC), production of reactive oxygen species (ROS) by PMNs and PMN adhesion to HUVEC were investigated.…”

Section: Antiviral Activity (Hiv/hcv)mentioning

confidence: 99%

“…The active compound (80) exhibited antiroliferative effect in LNCaP and immunomodulatory effect in immune cells of MS patients. 2 values of all the compounds was done against the agonist 2-methyl-5-hydroxytryptamine in longitudinal muscle myenteric plexus preparations from guinea pig ileum. Selected compounds demonstrated a higher pA 2 value, as compared to ondansetron (a standard 5-HT 3 receptor antagonist) and optimal log P-values were further screened in mice using behavioral tests such as a light-dark (L/D) aversion test, elevated plus maze (EPM) test, and an open field test (OFT) [148].…”

Section: Cannabinoid Receptors Agonists In Multiple Sclerosismentioning

confidence: 99%

“…Six different isomeric forms of naphthyridines are described based on the position of the nitrogens in the bicyclic system (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Madaan

Verma

Kumar

et al. 2015

Archiv der Pharmazie

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The 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide range of biological properties establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-osteoporotic (α(v)β(3) antagonists), anti-allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, anti-oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, β-3 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8-naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8-naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8-naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.

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Section: Antiviral Activity (Hiv/hcv)mentioning

confidence: 99%

Section: Antiviral Activity (Hiv/hcv)mentioning

confidence: 99%

Section: Cannabinoid Receptors Agonists In Multiple Sclerosismentioning

confidence: 99%

“…Six different isomeric forms of naphthyridines are described based on the position of the nitrogens in the bicyclic system (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Madaan

Verma

Kumar

et al. 2015

Archiv der Pharmazie

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“…Known that Gabriel rearrangement N-carboxymethyl-and N-phenaculphtalimids in a substituted 1,4-dioxiizohinolins under the influence of sodium alcoholate RONa [16][17][18][19]:…”

mentioning

confidence: 99%

A New Approach to Modification of Rearrangements in Metallorganic Chemistry of Phosphorus, Arsenic, Antimony and Bismuth

Zhakenovich¹,

Stepanovna²,

Vladimirovna³

et al. 2015

JCCE

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Abstract:We discovered a new approach modification Bamberger, Barton, Beckmann, Wallach, Gabriel, Hofmann, Hofmann A.W. Martius, Dimroth, Semmler-Wolff-Schroeter, Sus, Claisen, Newman-Kwart, Orton, Pistschimuka, Robev, Smiles, Sawdey, Sommelet, Stevens, Tiemann, Fischer-Hepp, Chapman, Chattaway, Schonberg, Stieglitz Rearrangements with of phosphorous, arsine, stibine and bismuthine in organometallic chemistry. The authors have proposed a new mechanism for possible reactions.

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TheSkraup Synthesis of Quinolines

Manske

Kulka

2011

Organic Reactions

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Konigs first synthesized quinoline in 1879 by passing allylaniline over heated litharge. Shortly after he prepared quinoline by heating the condensation product of aniline and acrolein, thus anticipating the classical Skraup synthesis. This synthesis involves a series of reactions brought about by heating a primary aromatic amine, in which at least one position ortho to the amino group is unsubstituted, with glycerol, sulfuric acid, and an oxidizing agent. The product is a quinoline containing only those substituents that were originally present in the aromatic amine. Quinolines substituted in the hetero ring may be obtained by a modified Skraup synthesis in which a substituted acrolein or a vinyl ketone is used in place of glycerol.

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The Naphthyridines.

Cited by 59 publications

References 24 publications

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

A New Approach to Modification of Rearrangements in Metallorganic Chemistry of Phosphorus, Arsenic, Antimony and Bismuth

TheSkraup Synthesis of Quinolines

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